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Molecular Cytogenetics / Protocols and Applications, Fan Yao-Shan

Molecular Cytogenetics / Protocols and Applications

Автор: Fan Yao-Shan
Название:  Molecular Cytogenetics / Protocols and Applications   (Молекулярная цитогенетика, протоколы и применения)
Издательство: Springer
Медицинская генетика

ISBN: 1588290069
ISBN-13(EAN): 9781588290069
ISBN: 1-58829-006-9
ISBN-13(EAN): 978-1-58829-006-9
Обложка/Формат: Hardcover
Страницы: 424
Вес: 0.802 кг.
Дата издания: 2003
Серия: Methods in Molecular Biology
Язык: ENG
Размер: 23.37 x 15.70 x 2.54 cm
Ссылка на Издательство: Link
Поставляется из: Германии
Описание: Yao-Shan Fan and a panel of senior scientists and pioneering researchers describe in step-by-step style the leading FISH techniques and those molecular technologies beyond FISH available for diagnostic services in genetics and oncology. The methods include labeling FISH probes for DNA and RNA targets, fluorescence genotyping, CGH microarray, spectral karyotyping/multicolor FISH, and primed in situ labeling. There are also techniques for multicolor fiber FISH, multi-telomere FISH, prenatal diagnosis using maternal blood, and preimplantation diagnosis. Oncological methods include simultaneous fluorescence immunophenotyping and FISH for leukemia and lymphoma, HER2 amplification in breast cancer, and CAC/PAC for cancer cytogenetics.
Дополнительное описание: Формат: 229x152
Илюстрации: 59
Круг читателей: Laboratory geneticists, clinical geneticists, cancer researchers, and technologists in diagnostic genetics laboratories
Ключевые слова:
Язык: eng

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Single Nucleotide Polymorphisms / Methods and Protocols

Автор: Kwok Pui-Yan
Название: Single Nucleotide Polymorphisms / Methods and Protocols
ISBN: 0896039684 ISBN-13(EAN): 9780896039681
Издательство: Springer
Цена: 1092 р.
Наличие на складе: Есть (2 шт.)
Описание: Pui-Yan Kwok, MD, PhD, has assembled a comprehensive collection of readily reproducible techniques for the difficult process of single nucleotide polymorphisms (SNP) discovery and genotyping. These cutting-edge protocols for mutation/SNP detection utilize denaturing high-performance liquid chromatography (dHPLC), single-strand conformation polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE), chemical cleavage, and direct sequencing. Equally powerful and up-to-date methods are given for genotyping SNPs, including molecular beacons, the Taqman assay, single-base extension approaches, pyrosequencing, ligation, the Invader assay, and primer extension with mass spectrometry detection.

Gene therapy protocols: Volume 1 preliminary entry 2071 production and in vivo applications of gene transfer vectors

Автор: LeDoux, Joseph (Ed.)
Название: Gene therapy protocols: Volume 1 preliminary entry 2071 production and in vivo applications of gene transfer vectors
ISBN: 1588299031 ISBN-13(EAN): 9781588299031
Издательство: Springer
Цена: 8084 р.
Наличие на складе: Нет в наличии.
Описание: Describes methods for the production of viral and non-viral gene transfer vectors, as well as protocols for critical applications in stem cell biology, cancer, diabetes, HIV and tissue engineering.

Cancer Cytogenetics / Methods and Protocols

Автор: Swansbury John
Название: Cancer Cytogenetics / Methods and Protocols
ISBN: 1588290808 ISBN-13(EAN): 9781588290809
Издательство: Springer
Цена: 6542 р.
Наличие на складе: Нет в наличии.
Описание: A collection of key cytogenetic and FISH techniques used by modern clinical laboratories in the genetic analysis of human malignancies. The book's practical advice and methods are suitable for use at every level of expertise, including fully established laboratories, but with a sympathetic bias towards anyone considering setting up a new cytogenetics service. Here the reader will find not only elementary tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH.

Molecular Motors / Methods and Protocols

Автор: Sperry Ann O.
Название: Molecular Motors / Methods and Protocols
ISBN: 1588296652 ISBN-13(EAN): 9781588296658
Издательство: Springer
Цена: 6157 р.
Наличие на складе: Нет в наличии.
Описание: Molecular motor proteins comprise three protein superfamilies: kinesins, dyneins and myosins. Together, these proteins produce force for movement in an incredibly wide variety of cellular processes including vesicular transport, cell division, nuclear migration, muscle contraction, mechanochemical transduction, among others. In addition, molecular motors are expressed in both simple eukaryotes and in a tissue specific manner in higher cells. This methods volume explores the extreme functional and structural diversity of molecular motors and presents methods relevant to each motor family. In addition, it describes techniques directed at motors that fall outside of the 3 characterized families (i.e. dynamin and F1ATPase). This volume of the Methods in Molecular Biology series is an essential reference for cell biologists examining the function of motor proteins in a range of model organisms using both in vitro and in vivo techniques. This volume is a valuble source for biochemists and molecular biologists as well.

Microbial Gene Essentiality: Protocols and Bioinformatics (Methods in Molecular Biology)

Автор: Gerdes Svetlana, Osterman Andrei L.
Название: Microbial Gene Essentiality: Protocols and Bioinformatics (Methods in Molecular Biology)
ISBN: 1588293785 ISBN-13(EAN): 9781588293787
Издательство: Springer
Цена: 7659 р.
Наличие на складе: Нет в наличии.
Описание: This book contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. In addition to wet-lab protocols, the book describes (i) statistical methods essential for planning successful large-scale essentiality screens, as well for data evaluation and analysis; (ii) in-silico prediction of gene essentiality using genome-scale reconstructed metabolic models; and (iii) data integration and comparative analysis in the context of genomic databases. All protocols follow the successful Methods in Molecular Biologyв„ў series format, each offering an introduction outlining the principles behind the techniques, step-by-step instructions, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls, and are intended for both novice and expert scientists.

Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols

Автор: Marx
Название: Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols
ISBN: 1617377260 ISBN-13(EAN): 9781617377266
Издательство: Springer
Цена: 6927 р.
Наличие на складе: Нет в наличии.
Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.

Molecular Beacons / Signalling Nucleic Acid Probes, Methods, and Protocols

Автор: Marx Andreas, Seitz Oliver
Название: Molecular Beacons / Signalling Nucleic Acid Probes, Methods, and Protocols
ISBN: 1588297004 ISBN-13(EAN): 9781588297006
Издательство: Springer
Цена: 6927 р.
Наличие на складе: Нет в наличии.
Описание: Significant DNA sequence data has been made availabe by several important genome projects. We clearly live in an exciting era, in which the allocation of functions to a mere string of the four letters in the code of life plays a major if not the predominant role of ongoing and future research. In functional genomics techniques are required that allow to examine the occurrence of gene products (be it RNA or protein material) and their interplay with other gene products, if possible, in real time. Again, once an important function has been identified there will be demands to trace or screen that function in in vitro and in vivo systems. For example, it may be necessary to detect dissimilarities in RNA expression between individuals or it may be required to detect pathogenes as rapid as possible. Progress in functional genomics as well as molecular diagnostics requires the availablity of methods that allow quantitative measurements in almost any environment, if desired even within living cells, with easy to use and inexpensive equipment.Recently, we have witnessed the emergence of powerful nucleic acids based reporter probes that are widely employed in studies ranging from genome diagnostics to basic enzymology. These versatile probes have been designed to signal binding of the probe to the target in homogeneous solution by changes of optical properties, most commonly fluorescence since fluorescence is a quantity that can be measured most conveniently and with high sensitivity by both experienced and first time users. It was perhaps the advent of polymerase chain reaction, enabling the extraction and enrichment of nucleic acid targets from virtually any source, that provided an important stimulus to probe development. It was soon recognized that probes can report the presence of target nucleic acids, for example, by using hybridization as a means to induce changes of the distance between two communicating chromophores. In the mid 90ties a seminal paper introduced new structured probe molecules and a new term, Molecular Beacons, which layed emphasis on one of the preferred properties that is positive signaling wherein formation of the probe-target complex results in increases of fluorescence rather than decreases. The conceptual elegance served as invaluable inspiration to chemists, physicists and biologists in the field. While originally being used for fluorogenic nucleic acid probes with a stem-loop structure, molecular beacon now refers to a whole family of fluorescence-up probes.

Quantum Dots / Applications in Biology

Автор: Hotz Charles Z, Bruchez Marcel
Название: Quantum Dots / Applications in Biology
ISBN: 1588295621 ISBN-13(EAN): 9781588295620
Издательство: Springer
Цена: 11162 р.
Наличие на складе: Нет в наличии.
Описание: Quantum Dots captures many diverse applications enabling utility in biological detection. Organized into five parts, the first two parts cover the use of QDs in imaging fixed and living cells (and tissues). Protocols are included for using QDs in routine (protein and structural cellular labeling), as well as enabling (single receptor trafficking, clinical pathology, correlative microscopy) applications. Part 3 shows early efforts aimed at using QDs in live animals. The final 2 parts demonstrate the versatility of QD technology in existing assay technology.

Linkage Disequilibrium and Association Mapping / Analysis and Applications

Автор: Collins Andrew R.
Название: Linkage Disequilibrium and Association Mapping / Analysis and Applications
ISBN: 1588296695 ISBN-13(EAN): 9781588296696
Издательство: Springer
Цена: 6157 р.
Наличие на складе: Нет в наличии.
Описание: As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

Microarrays / Volume II, Applications and Data Analysis

Автор: Rampal Jang B.
Название: Microarrays / Volume II, Applications and Data Analysis
ISBN: 1588299449 ISBN-13(EAN): 9781588299444
Издательство: Springer
Цена: 7466 р.
Наличие на складе: Нет в наличии.
Описание: Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments.Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Volume 2: Applications and Data Analysis includes insight into non-mammalian vertebrate systems, processes and protocols for high quality glass-based microarrays.Applications in DNA, peptide, antibody and carbohydrate microarraying, oligonucleotide microarrays generated from hydrolysis PCR probe sequences, microarray platforms in clinical practice, and screening of cDNA libraries on glass slide microarrays. Authors in this volume also discuss paraflo biochip for nucleic acid and protein analysis, volumetric mass spectrometry protein arrays, protocols for predicting DNA duplex stability on oligonucleotide arrays, and integrated analysis of microarray results.Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.

Microarray Data Analysis / Methods and Applications

Автор: Korenberg Michael J.
Название: Microarray Data Analysis / Methods and Applications
ISBN: 1588295400 ISBN-13(EAN): 9781588295408
Издательство: Springer
Цена: 6927 р.
Наличие на складе: Нет в наличии.
Описание: In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. This innovative book includes in-depth presentations of genomic signal processing, artificial neural network use for microarray data analysis, signal processing and design of microarray time series experiments, application of regression methods, gene expression profiles and prognostic markers for primary breast cancer, and factors affecting the cross-correlation of gene expression profiles. Also detailed are use of tiling arrays for large genome analysis, comparative genomic hybridization data on cDNA microarrays, integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors, gene and MeSH ontology, and survival prediction in follicular lymphoma using tissue microarrays.

Biochips / Technology and Applications

Автор: Xing Wan-Li, Cheng Jing
Название: Biochips / Technology and Applications
ISBN: 3540004238 ISBN-13(EAN): 9783540004233
Издательство: Springer
Цена: 6157 р.
Наличие на складе: Нет в наличии.
Описание: This book brings together contributions from internationally renowned experts in the biochip field. These chapters present not only the authors' latest research work, but also discuss current trends in biochip technology. Specific topics include microarray technology and its applications, microfluidics, drug discovery, detection technology, lab-on-chip technology and bioinformatics. Both newcomers to the field and experienced biochip researchers will benefit from this book.

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