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Cancer Drug Design and Discovery, Niedle

Cancer Drug Design and Discovery

Автор: Niedle
Название:  Cancer Drug Design and Discovery   (Лекарства против рака проектирование и открытие)
Издательство: Elsevier Science
Классификация:
Другие разделы медицины
Фармакология
Органическая химия

ISBN: 0123694485
ISBN-13(EAN): 9780123694485
ISBN: 0-12-369448-5
ISBN-13(EAN): 978-0-12-369448-5
Обложка/Формат: Hardcover
Страницы: 496
Вес: 1.318 кг.
Дата издания: 30.11.2007
Язык: ENG
Иллюстрации: Illustrations
Размер: 26.19 x 19.41 x 3.58 cm
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Англии
Описание: Covers available drugs as well as those under development and provides a clinical perspective on trials of anticancer agents. This book also presents drug discovery examples through the use of case histories.

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Cancer Drug Design and Discovery,

Автор: Stephen Neidle
Название: Cancer Drug Design and Discovery,
ISBN: 0123965217 ISBN-13(EAN): 9780123965219
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Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology

Автор: Trabocchi
Название: Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
ISBN: 1118145658 ISBN-13(EAN): 9781118145654
Издательство: Wiley
Цена: 11264 р.
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Drug Discovery and Development

Автор: Humphrey Rang
Название: Drug Discovery and Development
ISBN: 0443064202 ISBN-13(EAN): 9780443064203
Издательство: Elsevier Science
Цена: 4080 р.
Наличие на складе: Поставка под заказ.
Описание: Of the initial thousands of compounds with initial promise of drugs only a small handful be developed for human clinical trials and perhaps only one will become an approved drug. This book describes the huge complexities involved in bringing a drug to market and how molecular understanding and techniques can make the process more successful.
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Optimization in Drug Discovery

Автор: Yan Zhengyin, Caldwell Gary W.
Название: Optimization in Drug Discovery
ISBN: 1588293327 ISBN-13(EAN): 9781588293329
Издательство: Springer
Цена: 8852 р.
Наличие на складе: Нет в наличии.
Описание: A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.
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Drug Discovery in Pancreatic Cancer

Автор: Han
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Natural Products and Cancer Drug Discovery

Автор: Koehn
Название: Natural Products and Cancer Drug Discovery
ISBN: 1461446538 ISBN-13(EAN): 9781461446538
Издательство: Springer
Цена: 10777 р.
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Natural Products / Drug Discovery and Therapeutic Medicine

Автор: Zhang Lixin, Demain Arnold L.
Название: Natural Products / Drug Discovery and Therapeutic Medicine
ISBN: 1588293831 ISBN-13(EAN): 9781588293831
Издательство: Springer
Цена: 8852 р.
Наличие на складе: Нет в наличии.
Описание: A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
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Drug Discovery / A Casebook and Analysis

Автор: Maxwell Robert A., Eckhardt Shohreh B.
Название: Drug Discovery / A Casebook and Analysis
ISBN: 0896031802 ISBN-13(EAN): 9780896031807
Издательство: Springer
Цена: 8082 р.
Наличие на складе: Нет в наличии.
Описание: In their novel approach to Drug Discovery, Maxwell and Eckhardt explore their thesis that the discovery of new drugs-especially of innovative therapeutic agents-is an independent dynamic process that demands the full attention of researchers, rather than a spontaneous consequence of investigative research. Faced with a dearth of quantitative information on how and where innovative drugs were discovered, the authors have developed considerable quantitative data about this process in order to provide a deeper understanding of its true nature.Drug Discovery: A Casebook and Analysis offers a unique quantitative survey of research since World War II that led to the development of 32 innovative therapeutic agents. Factual and concise, each chapter presents a review of the original scientific contributions associated with the discovery of a specific drug. These chapters are followed by a computer analysis of important variables and finally by an interpretation. Drug categories discussed include: • cardiovascular and renal (including renal transplantation) • psychiatric • neurological • rheumatological • anesthesiological • pulmonary • gastrointestinal.
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Bioinformatics and Drug Discovery

Автор: Larson Richard S.
Название: Bioinformatics and Drug Discovery
ISBN: 1588293467 ISBN-13(EAN): 9781588293466
Издательство: Springer
Цена: 8467 р.
Наличие на складе: Нет в наличии.
Описание: A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
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Modern Methods of Drug Discovery

Автор: Hillisch Alexander, Hilgenfeld Rolf
Название: Modern Methods of Drug Discovery
ISBN: 376436081X ISBN-13(EAN): 9783764360818
Издательство: Birkhauser Verlag AG
Цена: 15334 р.
Наличие на складе: Нет в наличии.
Описание: This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery, complemented by an extensive list of references to the original literature. This concise source of information will be useful for researchers, both in industry and academia, as well as students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology.
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Drug Discovery and Evaluation / Pharmacological Assays

Автор: Vogel Hans G.
Название: Drug Discovery and Evaluation / Pharmacological Assays
ISBN: 3540298371 ISBN-13(EAN): 9783540298373
Издательство: Springer
Цена: 12317 р.
Наличие на складе: Нет в наличии.
Описание: Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.
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Structure-based Drug Discovery

Автор: Jhoti Harren, Leach Andrew R.
Название: Structure-based Drug Discovery
ISBN: 1402044062 ISBN-13(EAN): 9781402044069
Издательство: Springer
Цена: 10777 р.
Наличие на складе: Нет в наличии.
Описание: Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.
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Drug Discovery and Evaluation / Pharmacological Assays

Автор: Vogel Hans G.
Название: Drug Discovery and Evaluation / Pharmacological Assays
ISBN: 3540714200 ISBN-13(EAN): 9783540714200
Издательство: Springer
Цена: 46123 р.
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