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Metals in Medicine, 

Metals in Medicine


Название:  Metals in Medicine   (Металлы в медицине)
Издательство: Wiley
Классификация:
Фармакология
Органическая химия

ISBN: 0470681977
ISBN-13(EAN): 9780470681978
ISBN: 0-470-68197-7
ISBN-13(EAN): 978-0-470-68197-8
Обложка/Формат: Paperback
Страницы: 320
Вес: 0.61 кг.
Дата издания: 13.11.2009
Язык: ENG
Иллюстрации: Black & white tables, figures, charts, graphs
Размер: 24.13 x 18.54 x 2.03 cm
Читательская аудитория: Postgraduate, research & scholarly
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Англии
Описание: Today, metal-based drugs are commonplace in medicine. Metals in Medicine offers fundamental chemical reasoning behind the action of metal-based drugs for treating and diagnosing disease. This book examines the bonding concepts related to metallo-drugs, agents and substances interactions, as well as much more.
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Описание: Metals in Medicine is a textbook directed a senior undergraduates and beginning graduate students, which describes metal-based agents for treating and diagnosing disease. Opening chapters present basic bonding concepts that are applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background. Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Topics covered include cisplatin; platinum anticancer drugs; ruthenium, titanium, and gallium for treating cancer; gold compounds for treating arthritis, cancer, and other diseases; vanadium, copper, and zinc in medicine; metal complexes for diagnosing disease; and metalsi in nanomedicine. Throughout the book, Feature Boxes expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine. Metals in Medicine distills the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology, and bioengineering, and for researchers in other fields interested in getting a general insight into metals in medicine.
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