Автор: Armstrong Donald Название: Oxidative Stress Biomarkers and Antioxidant Protocols ISBN: 0896038505 ISBN-13(EAN): 9780896038509 Издательство: Springer Рейтинг: Цена: 18566 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.
Автор: Michael A. Tainsky (Ed.) Название: Tumor Biomarker Discovery ISBN: 1603278109 ISBN-13(EAN): 9781603278102 Издательство: Springer Рейтинг: Цена: 17368 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Through a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden. This title focuses on use and development of panels of biomarker analytes.
Автор: Peters Название: The Biomarker Guide ISBN: 0521786975 ISBN-13(EAN): 9780521786973 Издательство: Cambridge Academ Рейтинг: Цена: 12011 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These two volumes provide an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental and forensic scientists, natural product chemists and archaeologists. The Biomarker Guide is an all-inclusive reference detailing the origin of petroleum, technology for its analysis and key parameters for interpretation.
Автор: Peters Название: The Biomarker Guide 2 Volume Hardback Set ISBN: 0521837634 ISBN-13(EAN): 9780521837637 Издательство: Cambridge Academ Цена: 19800 р. Наличие на складе: Нет в наличии.
Описание: The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers are compounds found in crude oil with structures inherited from once-living organisms. They persist in oil spills, refinery products and archaeological artifacts, and can be used to identify the origin, geological age and environmental conditions prevalent during their formation and alteration. This Guide details the origin of petroleum, technology for its analysis and key parameters for interpretation. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental scientists and archaeologists.
Описание: Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. . Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research.
Автор: Panos Pardalos; Petros Xanthopoulos; Michalis Zerv Название: Data Mining for Biomarker Discovery ISBN: 1489996435 ISBN-13(EAN): 9781489996435 Издательство: Springer Рейтинг: Цена: 16769 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book applies data mining techniques to the discovery and analysis of new biomarkers. Presenting new results, models and algorithms, coverage focuses on biomarker data integration, information retrieval methods and statistical machine learning techniques.
Описание: This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from “cell to society” in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world.
Автор: Paul C. Guest Название: Multiplex Biomarker Techniques ISBN: 1493967290 ISBN-13(EAN): 9781493967292 Издательство: Springer Рейтинг: Цена: 17967 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed book arrives as there is an increasing need for multiplex biomarker readouts for improved clinical management and to support the development of new drugs by pharmaceutical companies, due to continuous technical developments and new insights into the high complexity of many diseases.
Описание: The only up-to-date text to focus on statistical analysis, Statistical Design and Analysis of Biomarker Studies discusses both the design and analyses required to develop biomarkers, and the types of designs and analyses that are done with these biomarkers once they are developed.
Автор: Weng Название: Target Biomarker Quantitation by LC-MS ISBN: 1119103061 ISBN-13(EAN): 9781119103066 Издательство: Wiley Рейтинг: Цена: 22301 р. Наличие на складе: Невозможна поставка.
Описание: The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years.
Автор: Looney Stephen W Название: Analysis of Biomarker Data ISBN: 1118027558 ISBN-13(EAN): 9781118027554 Издательство: Wiley Рейтинг: Цена: 14256 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A how to guide for applying statistical methods to biomarker data analysis Presenting a solid foundation for the statistical methods that are used to analyze biomarker data, Analysis of Biomarker Data: A Practical Guide features preferred techniques for biomarker validation.
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