Описание: Highly Commended, BMA Medical Book Awards 2015 Since the first edition of this book was published in 2004, the management of congenital heart disease has continued to evolve at a rapid pace. Not only have new operations been developed and expanded, such as the intra/extracardiac conduit Fontan and the double root translocation for corrected transposition, but in addition, diagnostic methods—particularly cardiac CT and MRI—have been dramatically transformed. Understanding of the genetic basis of congenital heart disease and the embryology of cardiac development has progressed even more rapidly. What has not changed is that optimal outcomes for children and adults with congenital heart disease can only be achieved by a collaborative team effort. The team includes not only congenital cardiac surgeons but also pediatric cardiac nurses, pediatric cardiologists, perfusion and respiratory technicians, pediatric cardiac intensivists, pediatric cardiac anesthesiologists, ultrasonographers, and MRI and catheter laboratory technicians. This second edition of Comprehensive Surgical Management of Congenital Heart Disease describes in detail the contemporary practice of Richard A. Jonas and the cardiac team at Children’s National Medical Center in Washington, D.C. The book once again includes numerous beautiful illustrations providing comprehensive and detailed information about intra-operative management of the entire spectrum of congenital heart surgery. In addition, the companion VitalSource ebook contains more than 50 operative videos that have been edited and narrated to highlight the key steps in complex surgical procedures. The book incorporates an evidence-based approach, supported throughout by numerous scientific citations, to explain when and why an operation should be done as well as the risks, benefits, and potential complications.
Автор: Nadia Rosenthal Название: Heart Development and Regeneration, ISBN: 0123813328 ISBN-13(EAN): 9780123813329 Издательство: Elsevier Science Рейтинг: Цена: 16830 р. Наличие на складе: Поставка под заказ.
Описание: The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration.
Автор: Benoit Bruneau G. Название: Heart Development,100 ISBN: 0123877865 ISBN-13(EAN): 9780123877864 Издательство: Elsevier Science Рейтинг: Цена: 14960 р. Наличие на складе: Поставка под заказ.
Описание: The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews.
Автор: Mihail Filipoiu Название: Atlas of Heart Anatomy and Development ISBN: 1447153812 ISBN-13(EAN): 9781447153818 Издательство: Springer Рейтинг: Цена: 15894 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the cardiac development and cardiac anatomy in the development of the adult heart. It features more than 500 images of dissected embryo and adult hearts made on human normal and pathological hearts of different ages.
Автор: Harvey Название: Heart Development Slide Set ISBN: 0123288401 ISBN-13(EAN): 9780123288400 Издательство: Elsevier Science Цена: 11220 р. Наличие на складе: Невозможна поставка.
Автор: Wu-Pong Susanna, Rojanasakul Yon Название: Biopharmaceutical Drug Design and Development ISBN: 1588297160 ISBN-13(EAN): 9781588297167 Издательство: Springer Рейтинг: Цена: 15894 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biopharmaceutical Drug Design and Development, Second Edition, furthers the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since that time. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel to a discussion on the dynamic, exciting field of biotechnology.
Автор: Rao Mahendra S. Название: Stem Cells and CNS Development ISBN: 0896038866 ISBN-13(EAN): 9780896038868 Издательство: Springer Рейтинг: Цена: 19224 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Reviews the findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. This book defines the classes of stem cells in the nervous system, compares their similarities and differences and discusses the gains made in identifying human homologs of neural stem cells.
Автор: Winterhager Elke Название: Gap Junctions in Development and Disease ISBN: 3540261567 ISBN-13(EAN): 9783540261568 Издательство: Springer Рейтинг: Цена: 18700 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Communication between cells via intercellular channels вЂ“ gap junctions вЂ“ appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Описание: Basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs. The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiography in clinical research, the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the ECG results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web based technology in clinical research, and how to follow the new FDA requirements for ECG submissions.
Описание: Since their first description in 1875, Merkel cells have remained an elusive cell type. Essential aspects of structure, development and function of normal Merkel cells and Merkel cell carcinoma are presented in short chapters, providing concise and up-to date information on this fascinating cell type.
Описание: This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.
Автор: KГјhl Michael Название: Wnt Signaling in Development ISBN: 0306478382 ISBN-13(EAN): 9780306478383 Издательство: Springer Рейтинг: Цена: 20477 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Wnt genes code for a family of secreted glycoproteins which fulfil important functions during the development of vertebrates and invertebrates. Wnts regulate as different aspects as differentiation, proliferation, cell migration, and cell polarity. Wnt proteins are able to activate different intracellular signaling cascades. This book describes different aspects of Wnt signaling during development of different species like the mouse, Xenopus, chicken, C. elegans or Drosophila and in different cellular contexts like heart formation or limb bud patterning. By doing such, this book provides, for the first time in printed form, an overview of the function of Wnt proteins during development. This book will be of interest to all professionals in the field of Wnt signaling, signal transduction or animal development.
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