Radical-mediated Protein Oxidation: From Chemistry to Medicine, Davies, Michael;Dean, Roger (both at The Heart Res
Название: Lipid Oxidation In Health & Disease ISBN: 1482202859 ISBN-13(EAN): 9781482202854 Издательство: Taylor&Francis Рейтинг: Цена: 12018 р. Наличие на складе: Поставка под заказ.
Oxidative modification of lipids and phospholipids--including radical damage, halogenation, and nitration--result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.
Covering the diverse topics that contribute to research in this important field, this book explores:
The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
Antioxidant defenses and lipid oxidation
Lipid oxidation products and cell signaling
The roles of oxidized lipids in specific diseases--including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
Drug targeting and the therapeutic potential of oxidized lipids
Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.
Автор: Grune Название: Protein Oxidation and Aging ISBN: 0470878282 ISBN-13(EAN): 9780470878286 Издательство: Wiley Рейтинг: Цена: 13585 р. Наличие на складе: Поставка под заказ.
Описание: Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently b
Описание: In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.
Описание: This book summarizes the chemical mechanisms and detailed kinetics of amino acid and peptide oxidation to help understand how proteins break down or dissociate when under stress in biological and environmental systems so that new drugs and antioxidants may be developed.
Автор: Nathan P. Kaplan Название: Oxidation and Phosphorylation,10 ISBN: 0121818500 ISBN-13(EAN): 9780121818500 Издательство: Elsevier Science Рейтинг: Цена: 5138 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Lipid-Mediated Signaling Transducti ISBN: 1498768342 ISBN-13(EAN): 9781498768344 Издательство: Taylor&Francis Рейтинг: Цена: 15257 р. Наличие на складе: Поставка под заказ.
Описание: Catalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech catalysts, which add enormously to the repertoire of synthetic possibilities. However, catalysts are occasionally capricious, sometimes difficult to use and almost always require both skill and experience in order to achieve optimal results. This series aims to be a practical help for advanced undergraduate, graduate and postgraduate students, as well as experienced chemists in industry and academia working in organic and organometallic synthesis. The series features: tested and validated procedures; authoritative reviews on classes of catalysts; assessments of all types of catalysts; and expertise from the Leverhulme Centre for Innovative Catalysis, Liverpool, UK. The review section in the first volume of the series contains a report by Stanley M. Roberts on the integration of biotransformations into the catalyst portfolio. The procedure section contains a wide variety of synthetic protocols, such as epoxidations of unsaturated ketones and esters, asymmetric reductions of carbon-oxygen double bonds, asymmetric hydrogenations of carbon-carbon double bonds and other types of reaction. The featured catalysts include a wide range of different materials such as poly-D-leucine, D-fructose-based dioxiranes, oxaborolidine borane, some important titanium and ruthenium complexes as well as baker's yeast. For each reaction there are one or several detailed protocols on how to prepare and employ the various catalysts.
Автор: E N Frankel Название: Lipid Oxidation, ISBN: 0953194981 ISBN-13(EAN): 9780953194988 Издательство: Elsevier Science Рейтинг: Цена: 18233 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In his definitive book on lipid oxidation, Professor Frankel`s main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed.
Автор: Lotzova Название: Nk Cell Mediated Cytotoxicity ISBN: 0849362679 ISBN-13(EAN): 9780849362675 Издательство: Taylor&Francis Рейтинг: Цена: р. Наличие на складе: Поставка под заказ.
Описание: Offers a survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. This work discusses specific topics including NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. It is suitable for scientists, clinicians, and students.