Sodium Channels and Neuronal Hyperexcitability - No. 241, Novartis Foundation
Автор: Stephen Waxman Название: Multiple Sclerosis As A Neuronal Disease, ISBN: 0127387617 ISBN-13(EAN): 9780127387611 Издательство: Elsevier Science Рейтинг: Цена: 20900 р. Наличие на складе: Поставка под заказ.
Описание: Examines the role of neurons in Multiple Sclerosis (MS) and the changes that occur in neurons as a result of MS. This book explains the basis for symptom production, remission and progress in MS. It brings together information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of MS.
Описание: Ion channels provide a unique opportunity to use computational approaches to attempt an understanding of the function of a membrane protein, starting with an atomic resolution structure and progressing through a hierarchy of theoretical descriptions until one can account quantitatively for their physiological function. This book brings together physiologists, structural biologists and theorists who came together to help define the direction of the field in the immediate future. Topics covered include: * the x-ray structure of channels and pores * computer simulation of channel function * detailed data on potassium channels, chloride and calcium channels, and ligand-gated ion channels
Описание: It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.
Автор: Gupta Название: Ion Channels and Their Inhibitors ISBN: 3642199216 ISBN-13(EAN): 9783642199219 Издательство: Springer Рейтинг: Цена: 13672 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.
Описание: Understanding the crucial link between basic science discovery and the development of therapeutic regimens for clinical disease offers the greatest potential to either prevent or reverse central nervous system disability. Neuronal and Vascular Plasticity: Elucidating Basic Cellular Mechanisms for Future Therapeutic Discovery addresses novel repair mechanisms for cellular injury and integrates current knowledge of basic disease mechanisms of the brain with clinical approaches. This volume is intended to serve as a strong reference for those entering the clinical neurosciences as well as for those established in the field.
Описание: This book details the latest aspects of the culture of neural cells and explains the practical and theoretical considerations of the techniques involved. It features step-by-step, readily reproducible laboratory protocols and expert implementation advice.
Описание: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. . With chapters authored by experts in each topic, this book advances the understanding of:. . How the brain carries out important tasks via networks. How these networks interact in normal brain function. Major mechanisms that control network function. The interaction of the normal networks to produce more complex behaviors. How brain disorders can result from abnormal interactions. How therapy of disorders can be advanced through this network approach. This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders.
Описание: This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.
Описание: Information-Processing Channels in the Tactile Sensory System addresses the fundamental question of whether sensory channels, similar to those known to operate in vision and audition, also operate in the sense of touch. Based on the results of psychophysical and neurophysiological experimentation the authors make a powerful case that channels operate in the processing of mechanical stimulation of the highly sensitive glabrous skin of the hand. According to the multichannel model presented in this monograph, each channel, with its specific type of mechanoreceptor and afferent nerve fiber, responds optiimally to particular aspects of the tactile stimulus. It is further proposed that the tactile perception of objects results from the combined activity of the individual tactile channels. This work is important because it provides researchers and students in the field of sensory neuroscience with a comprehensive model that enhances our understanding of tactile perception.
Описание: Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. This book offers a picture of the field.
Описание: Dealing with neuronal networks within the brain, this book covers reviews and studies of topics selected to bridge different levels of neurobiological organization, from the molecular, cellular, neural network to the cognitive level. It illustrates the state of understanding of network development, plasticity and functioning of the visual system.
Автор: Zatta P Et Al Название: Non-Neuronal Cells In Alzheimer`S Disease ISBN: 9810220928 ISBN-13(EAN): 9789810220921 Издательство: World Scientific Publishing Рейтинг: Цена: 7477 р. Наличие на складе: Поставка под заказ.
Описание: This text presents current research into the effect of Alzheimer`s disease on non-neuronal cells, rather than the central nervous system. It provides up-to-date information on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies.
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