Bayesian Approaches to Clinical Trials and Health-Care Evaluation, David J. Spiegelhalter
Автор: Glick, Henry A.; Doshi, Jalpa A.; Sonnad, Seema S. Название: Economic Evaluation in Clinical Trials ISBN: 0199685029 ISBN-13(EAN): 9780199685028 Издательство: Oxford Academ Рейтинг: Цена: 4945 р. Наличие на складе: Поставка под заказ.
Описание: A a practical guide to the techniques and issues involved in conducting economic evaluation in ongoing clinical trials, supported with detailed advice on the design and analysis of studies including analysis of cost effectiveness and methodological integrity.
Автор: Tom Brody Название: Clinical Trials ISBN: 0128042176 ISBN-13(EAN): 9780128042175 Издательство: Elsevier Science Рейтинг: Цена: 8250 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.
Описание: This text look at cross-over trials which are experiments in which subjects, whether patients or healthy volunteers, are each given a number of treatments with the object being to study the differences between these treatments. They are used extensively in clinical research.
Описание: Each section is followed with expert commentary and a critical evaluation of the studies under consideration! This reference, unique in format, gathers the most relevant clinical studies, reviews the different biochemical properties, and assesses the therapeutic efficacy of low molecular weight heparins (LMWHs) from 1985 to the present. Presents each study on two pages-the first describes the main parameters of the study, including experimental conditions, location, number of patients, medications, surgical procedures, and anesthesia type, and the second provides a table of results based on the study's data! With contributions from 35 leading international physicians, Low Molecular Weight Heparin Therapy
recommends treatment practices based on levels of evidence attained in the studies
questions specific therapeutic practices when researchers fail to
provides systematic documentation of the various therapeutic indications of LMWHs
compares the benefits of LMWHs prophylaxis with the risk of hemorrhage
evaluates the ease of delivery of prophylactic therapy and treatment of thromboembolic disease
favors narrative review of each study over meta-analysis
and more! Containing hundreds of tables, and scrupulously referenced to substantiate the critical appraisals, Low Molecular Weight Heparin Therapy is a single-volume reference ideal for anesthesiologists, surgeons, primary care physicians, internists, cardiologists, hematologists, pharmacologists, epidemiologists, and medical students in these disciplines.
Описание: Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretat
Автор: Moye Название: Elementary Bayesian Biostatistics ISBN: 1584887249 ISBN-13(EAN): 9781584887249 Издательство: Taylor&Francis Рейтинг: Цена: 9123 р. Наличие на складе: Невозможна поставка.
Описание: Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of non-informative priors as
well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian procedures, "Elementary Bayesian
Biostatistics" explores Bayesian principles and illustrates their application to healthcare research. Building on the basics of classic biostatistics and algebra, this easy-to-read book
provides a clear overview of the subject.
It focuses on the history and mathematical foundation of Bayesian procedures, before discussing their implementation in healthcare
research from first principles. The author also elaborates on the current controversies between Bayesian and frequentist biostatisticians.This book concludes with recommendations for
Bayesians to improve their standing in the clinical trials community. Calculus derivations are relegated to the appendices so as not to overly complicate the main text.
Bayesian methods gain more acceptance in healthcare, it is necessary for clinical scientists to understand Bayesian principles. Applying Bayesian analyses to modern healthcare
research issues, this lucid introduction helps readers make the correct choices in the development of clinical research programs.
Описание: A unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to sufficiency and ancillarity. Developments in stochastic processes and applied probability are also given where appropriate. Intuition is stressed over mathematics, but not without a clear development of the latter in the context of the former. Providing a consolidated review of the field, the book includes relevant and practical discussions of: * The benefits of randomization in terms of reduction of bias * Randomization as a basis for inference * Covariate-adaptive and response-adaptive randomization * Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computer simulations using SAS, Randomization in Clinical Trials: Theory and Practice is equally useful as a standard textbook in biostatistics graduate programs as well as a reliable reference for biostatisticians in practice.
Автор: Berry, Donald A. Berry, Scott M. Carlin, Bradley P Название: Bayesian adaptive methods for clinical trials ISBN: 1439825483 ISBN-13(EAN): 9781439825488 Издательство: Taylor&Francis Рейтинг: Цена: 10394 р. Наличие на складе: Невозможна поставка.
Описание: Explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis. This book summarizes the state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative.
Автор: Rosenberger William F Название: Randomization in Clinical Trials ISBN: 1118742249 ISBN-13(EAN): 9781118742242 Издательство: Wiley Рейтинг: Цена: 11377 р. Наличие на складе: Поставка под заказ.
Описание: Praise for the First Edition: All medical statisticians involved in clinical trials should read this book Controlled Clinical Trials Featuring a unique combination ofthe applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go–to guide for biostatisticians and pharmaceutical industry statisticians. A consolidated review of the field, the Second Edition focuses on computation of randomized tests rather than the asymptotic theory of randomized tests. Randomization in Clinical Trials: Theory and Practice, Second Edition features: A discussion on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate–adjusted response–adaptive randomization, including minimization techniques and inference for covariate–adaptive randomization New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Many problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, to simplify the mathematics, and to ease understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper–undergraduate and graduate–level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles and The Theory of Response–Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as the Department of Statistics at The George Washington University. He is a fellow of the American Statistical Association and the Society for Clinical Trials and is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Описание: High levels of uncertainty are a trademark of geological investigations, such as the search for oil, diamonds, and uranium. So business ventures related to geology, such as mineral exploration and mining, are naturally associated with higher risks than more traditional entrepreneurial ventures in industry and economy. There are also a number of dangerous natural hazards, e.g. earthquakes, volcanic activities, and inundations, that are the direct result of geological processes. It is of paramount interest to study them all, to describe them, to understand their origin and - if possible - to predict them. While uncertainties, geological risks and natural hazards are often mentioned in geological textbooks, conferences papers, and articles, no comprehensive and systematic evaluation has so far been attempted. This book, written at an appropriately sophisticated level to deal with complexity of these problems, presents a detailed evaluation of the entire problem, discussing it from both, the geological and the mathematical aspects.
Описание: This expanded and updated edition includes the many innovations and clinical research methods that have developed since the first edition, as well as current information on the regulatory, legal, and reimbursement environment for medical devices. The authors summarize the key principles and approaches employed in medical device clinical trials and illustrate their uses in a revealing series of detailed, real-world case studies. Highlights include new information on the requirements and process for gaining reimbursement from Medicare and private insurers on new products -including new case studies of research specifically designed for this purpose-and new statistical methods applied to medical device trials. Additional case studies provide examples of combination products, three-phase development models (i.e., feasibility, FDA approval, and Medicare reimbursement), and novel study designs. The cases demonstrate a wide range of designs that have been successfully applied to many different research problems, as well as to a variety of therapeutic or diagnostic products.