Bayesian Approaches to Clinical Trials and Health-Care Evaluation, David J. Spiegelhalter
Автор: Glick, Henry A.; Doshi, Jalpa A.; Sonnad, Seema S. Название: Economic Evaluation in Clinical Trials ISBN: 0199685029 ISBN-13(EAN): 9780199685028 Издательство: Oxford Academ Рейтинг: Цена: 4474 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A a practical guide to the techniques and issues involved in conducting economic evaluation in ongoing clinical trials, supported with detailed advice on the design and analysis of studies including analysis of cost effectiveness and methodological integrity.
Автор: Moye Название: Elementary Bayesian Biostatistics ISBN: 1584887249 ISBN-13(EAN): 9781584887249 Издательство: Taylor&Francis Рейтинг: Цена: 8254 р. Наличие на складе: Невозможна поставка.
Описание: Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of non-informative priors as
well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian procedures, "Elementary Bayesian
Biostatistics" explores Bayesian principles and illustrates their application to healthcare research. Building on the basics of classic biostatistics and algebra, this easy-to-read book
provides a clear overview of the subject.
It focuses on the history and mathematical foundation of Bayesian procedures, before discussing their implementation in healthcare
research from first principles. The author also elaborates on the current controversies between Bayesian and frequentist biostatisticians.This book concludes with recommendations for
Bayesians to improve their standing in the clinical trials community. Calculus derivations are relegated to the appendices so as not to overly complicate the main text.
As
Bayesian methods gain more acceptance in healthcare, it is necessary for clinical scientists to understand Bayesian principles. Applying Bayesian analyses to modern healthcare
research issues, this lucid introduction helps readers make the correct choices in the development of clinical research programs.
Автор: Berry, Donald A. Berry, Scott M. Carlin, Bradley P Название: Bayesian adaptive methods for clinical trials ISBN: 1439825483 ISBN-13(EAN): 9781439825488 Издательство: Taylor&Francis Рейтинг: Цена: 9404 р. Наличие на складе: Невозможна поставка.
Описание: Explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis. This book summarizes the state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative.
Автор: Rosenberger William F Название: Randomization in Clinical Trials ISBN: 1118742249 ISBN-13(EAN): 9781118742242 Издательство: Wiley Рейтинг: Цена: 10293 р. Наличие на складе: Поставка под заказ.
Описание: Praise for the First Edition: All medical statisticians involved in clinical trials should read this book Controlled Clinical Trials Featuring a unique combination ofthe applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go–to guide for biostatisticians and pharmaceutical industry statisticians. A consolidated review of the field, the Second Edition focuses on computation of randomized tests rather than the asymptotic theory of randomized tests. Randomization in Clinical Trials: Theory and Practice, Second Edition features: A discussion on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate–adjusted response–adaptive randomization, including minimization techniques and inference for covariate–adaptive randomization New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Many problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, to simplify the mathematics, and to ease understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper–undergraduate and graduate–level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles and The Theory of Response–Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as the Department of Statistics at The George Washington University. He is a fellow of the American Statistical Association and the Society for Clinical Trials and is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Описание: High levels of uncertainty are a trademark of geological investigations, such as the search for oil, diamonds, and uranium. So business ventures related to geology, such as mineral exploration and mining, are naturally associated with higher risks than more traditional entrepreneurial ventures in industry and economy. There are also a number of dangerous natural hazards, e.g. earthquakes, volcanic activities, and inundations, that are the direct result of geological processes. It is of paramount interest to study them all, to describe them, to understand their origin and - if possible - to predict them. While uncertainties, geological risks and natural hazards are often mentioned in geological textbooks, conferences papers, and articles, no comprehensive and systematic evaluation has so far been attempted. This book, written at an appropriately sophisticated level to deal with complexity of these problems, presents a detailed evaluation of the entire problem, discussing it from both, the geological and the mathematical aspects.
Описание: This expanded and updated edition includes the many innovations and clinical research methods that have developed since the first edition, as well as current information on the regulatory, legal, and reimbursement environment for medical devices. The authors summarize the key principles and approaches employed in medical device clinical trials and illustrate their uses in a revealing series of detailed, real-world case studies. Highlights include new information on the requirements and process for gaining reimbursement from Medicare and private insurers on new products -including new case studies of research specifically designed for this purpose-and new statistical methods applied to medical device trials. Additional case studies provide examples of combination products, three-phase development models (i.e., feasibility, FDA approval, and Medicare reimbursement), and novel study designs. The cases demonstrate a wide range of designs that have been successfully applied to many different research problems, as well as to a variety of therapeutic or diagnostic products.
Описание: Equips pharmacy professionals with the tools necessary to advance their practice through public relations. The first book designed specificallor pharmacists, it explains how to work with the media; how to write news releases, public service announcements, and op-ed pieces; how to prepare for media interviews; how to work with PR agencies; and how to become involved in the community. The book contains lists of public relations do's and don'ts, points to consider, and tips for succeeding. Examples of successful PR activities and campaign and sample news release, public service announcement, op-ed article, and media pitch letter are also included.
Автор: Bhushan Patwardhan Название: Integrative Approaches for Health ISBN: 012801282X ISBN-13(EAN): 9780128012826 Издательство: Elsevier Science Рейтинг: Цена: 6054 р. 6727.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite spectacular advances, modern medicine faces formidable global challenges in several key areas—notably the persistence of major killer diseases such as malaria, tuberculosis, leprosy, and newer threats including HIV/AIDS, resistant infections, and Ebola. As such, modern medicine has not led to a significant decrease in chronic diseases like diabetes, obesity, and other degenerative and autoimmune diseases. The authors believe that modern medicine needs to experience a paradigm shift, an integration of traditions—in particular from the ancient systems like Ayurveda and Yoga. Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga brings together the basic principles of interdisciplinary systems approach for an evolving construct of future medicine. Such an approach is already emerging at the cutting edge of current research in omics, bioinformatics, computational and systems biology. Several leading institutions of medicine have adopted Yoga and complementary medicine to widen their reach, and deepen effectiveness in therapeutic practices. The amalgam of modern medicine, with its strengths in scientific rigor, blended with the basic principles of life drawn from Ayurveda and Yoga might evolve into a medicine of tomorrow. Integrative approaches are no longer alternative, perhaps taking these approaches is the only possible way to heal our sick planet. This book introduces important trends and tools for biomedical researchers and physicians alike, to innovate the practice of medicine for the better.
Описание: Introduces varying ideas on research, important in the days of inter disciplinary and multi centered investigation. This book presents the contributions in an historical and theoretical context, identifying the themes between the approaches, and encourages new thinking about old problems.
Автор: Tom Brody Название: Clinical Trials ISBN: 0128042176 ISBN-13(EAN): 9780128042175 Издательство: Elsevier Science Рейтинг: Цена: 6644 р. 7382.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.
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