Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, Robert Crichton
Автор: Brown David R. Название: Neurodegeneration and Prion Disease ISBN: 0387239227 ISBN-13(EAN): 9780387239224 Издательство: Springer Рейтинг: Цена: 19634 р. Наличие на складе: Поставка под заказ.
Описание: This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cowвЂ™s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
Описание: Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, in
Описание: Comprises the developments regarding pathology, pathophysiology, as well as the molecular and genetic backgrounds of the major neurodegenerative diseases. This work also presents the important clinical findings, a summary of therapies and available experimental models.
Автор: Harry Jean, Tilson Hugh A. Название: Neurodegeneration Methods and Protocols ISBN: 089603612X ISBN-13(EAN): 9780896036123 Издательство: Springer Рейтинг: Цена: 16746 р. Наличие на складе: Поставка под заказ.
Описание: An outstanding collection of detailed, state-of-the-art techniques for studying many aspects of nervous system cell biology. The methods span a multidisciplinary range of cellular and molecular approaches to both normal and injured nervous system function, and particularly to neurodegenerative processes. Included are basic RT-PCR techniques, cell culture systems, second-messenger signaling methods, and patch-clamp techniques. These powerful techniques will illuminate nervous system function, injury, degeneration, and the repair/regenerative process.
Описание: As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment.? Developing strategies to prevent degeneration of neurons and to promote a heal
Название: Neurodegeneration ISBN: 1405196939 ISBN-13(EAN): 9781405196932 Издательство: Wiley Рейтинг: Цена: 27906 р. Наличие на складе: Поставка под заказ.
Описание: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.? In contrast, this book looks to the future and uses a classification based upon molecular m
Автор: Broderick Название: Bioimaging in Neurodegeneration ISBN: 1588293912 ISBN-13(EAN): 9781588293916 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: Bioimaging in Neurodegeneration fulfills the current need to bridge the diagnoses of neurodegenerative diseases with the technologies that enable their
accurate diagnoses. This book covers four clinical areas of neurodegenerative disease: Parkinson's, Alzheimer's, Epilepsy, and Leukodystrophy (White Matter), and the wide array of
devices used to diagnose them.
Описание: In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.
Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.
Описание: Marie-FranГ§oise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Автор: Kailash P Bhatia Название: Metal Related Neurodegenerative Disease,110 ISBN: 0124105025 ISBN-13(EAN): 9780124105027 Издательство: Elsevier Science Рейтинг: Цена: 18480 р. Наличие на складе: Поставка под заказ.
Описание: This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related diseaseis also presented.
Описание: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
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