Автор: Susanne Klumpp
Название: Protein Phosphatases,366
ISBN: 0121822699 ISBN-13(EAN): 9780121822699
Издательство: Elsevier Science
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Описание: Protein phosphatases are a group of enzymes responsible for the dephosphorylation of various proteins and enzymes in a cell. This role is an extremely important one since protein phosphorylation and dephosphorylation is required for the regulation of a large number of cellular activities.

Автор: Pulido
Название: Protein Tyrosine Phosphatases
ISBN: 1493937448 ISBN-13(EAN): 9781493937448
Издательство: Springer
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Цена: 9074 р.
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Описание: This book provides coverage, methodology, and laboratory protocols on the more essential aspects of protein tyrosine phosphatase (PTP) function and regulation, including the use of standardized in vitro functional assays, suitable cell systems, and animal and microorganism models. Chapters covering state-of-the-art technical approaches suitable to decipher the physiologic roles of PTPs, and their involvement in tissue-specific functions, are also included, which will be of utility for both newcomers and experienced researchers in the field of tyrosine- and phosphoinositide- phosphorylation/dephosphorylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Автор: Neel
Название: Protein Tyrosine Phosphatases in Cancer
ISBN: 1493936476 ISBN-13(EAN): 9781493936472
Издательство: Springer
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Цена: 13877 р.
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Описание: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.

Автор: Goldstein, Barry J.
Название: Tyrosine Phosphoprotein Phosphatases 2/e (Paperback)
ISBN: 0198502478 ISBN-13(EAN): 9780198502470
Издательство: Oxford Academ
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Цена: 7916 р.
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Описание: Tyrosine phosphoprotein phosphatases are a family of enzymes found ubiquitously in cells, and are involved in a number of metabolic and signalling pathways. This volume explores their sequence, structure, and biochemical properties, providing a unique reference work for researchers. It also includes an extensive, categorized bibliography.

Автор: Arino JoaquГ­n, Alexander Denis R.
Название: Protein Phosphatases
ISBN: 3540205608 ISBN-13(EAN): 9783540205609
Издательство: Springer
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Цена: 30443 р.
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Описание: This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.

Автор: Butler, M.
Название: Mammalian Cell Biotechnology A Practical Approach (Paperback)
ISBN: 019963209X ISBN-13(EAN): 9780199632091
Издательство: Oxford Academ
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Цена: 9126 р.
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Описание: The development of mammalian cell biotechnology has led to an extensive range of prophylactic, diagnostic and therapeutic compounds which can be produced routinely by cell culture. This book details the principles and practical techniques upon which this development is based and which can be applied to maximize the productivity of cell cultures.

Автор: Hu
Название: Genomics and Systems Biology of Mammalian Cell Culture
ISBN: 3642283497 ISBN-13(EAN): 9783642283499
Издательство: Springer
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Цена: 26985 р.
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Описание: Transcriptome Analysis, by Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam L?bbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome Data Analysis for Cell Culture Processes, by Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, by Ziomara P. Gerdtzen Metabolic Flux Analysis in Systems Biology of Mammalian Cells, by Jens Niklas und Elmar Heinzle Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data, by Jochen Schaub, Christoph Clemens, Hitto Kaufmann und Torsten W. Schulz Protein Glycosylation and Its Impact on Biotechnology, by Markus Berger, Matthias Kaup und V?ronique Blanchard Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects, by Patrick Hossler Modeling of Intracellular Transport and Compartmentation, by Uwe Jandt und An-Ping Zeng Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, by L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser und D. Wirth.

Автор: Abou-Donia
Название: Mammalian Toxicology
ISBN: 1119940419 ISBN-13(EAN): 9781119940418
Издательство: Wiley
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Цена: 7480 р.
Наличие на складе: Нет в наличии.

Описание: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention, and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples of various toxicants Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenicity, male and female reproductive toxicity, mutagenicity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical–induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Автор: Hartley
Название: Protein Expression in Mammalian Cells
ISBN: 1617793515 ISBN-13(EAN): 9781617793516
Издательство: Springer
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Цена: 9899 р.
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Описание: Through all of the recent progress provided by high throughput DNA sequencing technologies, it has become clearer and clearer that the study of proteins and protein organelles will be the key to unlocking our ability to manipulate cells and intervene in human disease.  In Protein Expression in Mammalian Cells: Methods and Protocols, expert researchers in the field present a compendium of vital techniques to further our knowledge of mammalian protein expression.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and concise, Protein Expression in Mammalian Cells: Methods and Protocols will aid scientists seeking to delve deeper into our own biology through the medium of other mammalian cells and proteins.

Автор: Gardner, David K.; Lane, Michelle; Watson, Andrew
Название: A Laboratory Guide to the Mammalian Embryo (Paperback)
ISBN: 0195142268 ISBN-13(EAN): 9780195142266
Издательство: Oxford Academ
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Цена: 3957 р.
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Описание: Never before has there been such a comprehensive book of protocols. This compendium offers a full range of research techniques-from cell culture, to biochemical, to microscopic and genetic. More focused books, like Cold Spring Harbor`s Manipulating the Mouse Embryo, are similar though more narrow in scope. This book will appeal to a broad range of researchers, from basic experimental scientists to clinical and animal scientists.

Автор: S.C. Makrides
Название: Gene Transfer and Expression in Mammalian Cells,38
ISBN: 044451371X ISBN-13(EAN): 9780444513717
Издательство: Elsevier Science
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Цена: 21863 р.
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Описание: The production of proteins in mammalian cells is an important tool in numerous scientific and commercial areas. For example, proteins for human therapy, vaccination or diagnostic applications are typically produced in mammalian cells. Gene cloning, protein engineering, biochemical and biophysical characterization of proteins also require the use of gene expression in mammalian cells.

Other applications in widespread use involve screening of libraries of chemical compounds in drug discovery, and the development of cell-based biosensors. This book presents a state-of-the-art comprehensive coverage of the technical aspects of gene expression in mammalian cells, written by experienced scientists working at the forefront of the field.

Автор: Heiser William C.
Название: Gene Delivery to Mammalian Cells / Volume 1: Nonviral Gene Transfer Techniques
ISBN: 1588290867 ISBN-13(EAN): 9781588290861
Издательство: Springer
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Цена: 11962 р.
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Описание: Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics. An accompanying volume, Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors.