Описание: WatsonвЂ“Crick hybridization of complementary sequences in nucleic acids is one of the most important processes necessary for molecular recognition in vivo, as well as nucleic acid identification and isolation. This book is devoted to a large family of in vitro DNA hybridization-based experimental techniques. A wide spectrum of experimental tasks covered by these approaches includes finding differential sequences in both genomic DNAs and mRNAs, genome walking, multiplex PCR, cDNA library construction starting from minute amount of total RNA, rapid amplification of cDNA 5вЂ™ and 3вЂ™ ends, effective smoothing of the concentrations of rare and abundant transcripts in cDNA libraries, recovery of promoter active repeats and differentially methylated genomic DNA, identification of common sequences in genomic or cDNA sources, new gene mapping, finding evolutionary conserved DNA and both single-nucleotide and extended mutation discovery or large-scale monitoring. Several approaches, such as microarray hybridization, have become extremely popular tools for specialists in biochemistry and in biomedicine, whereas the potential of many other advantageous techniques seems to be underestimated now. The international team of the authors of this book has tried both to elucidate the current state-of-art in hybridization techniques and to help the readers in choosing an appropriate method for performing an experiment in the most efficient way. Enclosed experimental protocols along with both comprehensive and detailed method descriptions make this truly universal book useful to all those interested in the modern life science methodologies.
Автор: K Park Название: Biomaterials for Cancer Therapeutics, ISBN: 0857096648 ISBN-13(EAN): 9780857096647 Издательство: Elsevier Science Рейтинг: Цена: 23678 р. Наличие на складе: Поставка под заказ.
Описание: Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.
Описание: The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids. There are a modest number of laboratories involved in this field, nevertheless the number of papers published by researchers is extensive. The articles which will be published in this meeting report will be a valuable contribution for researchers and research students alike and will help them to stay on top of the developments in different research areas and to „cross borders“ between them.
Описание: DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.
Описание: Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity.
Описание: Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.
Описание: The book`s many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis.
Описание: Combines two aspects, namely cancer research and the drug design and delivery from an integrated perspective of cancer treatment. This book describes various aspects of anticancer strategies and drug delivery approaches from different perspectives, including detailed discussion of several clinical trial cases.
Автор: David S. Ettinger; Ross Donehower (Eds.) Название: Current Cancer Therapeutics ISBN: 1573402850 ISBN-13(EAN): 9781573402859 Издательство: Springer Рейтинг: Цена: 18349 р. Наличие на складе: Поставка под заказ.
Описание: Presents the combined efforts of experts in pharmacologic oncology treatment. This book features summaries and charts of topics such as pharmacokinetics, drug indications, and toxicities. It provides protocols for treatment and supportive care of cancer patients. It is suitable for oncologists professionals involved in the treatment of cancer.
Описание: The urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains. This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targeted therapeutics. It offers coverage of various aspects of a selected domain of tumor immunology.
Описание: Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long–term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.
Автор: Shah Название: Stem Cell Therapeutics for Cancer ISBN: 1118282426 ISBN-13(EAN): 9781118282427 Издательство: Wiley Рейтинг: Цена: 17325 р. Наличие на складе: Поставка под заказ.
Описание: A single-source reference on the hot topic of stem cell therapeutics for cancer This work offers a thorough, cohesive look at the state of the art of stem cell therapeutics for cancer, with an emphasis on the unique application of mesenchymal stem cells
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