Описание: Gastrointestinal mucosal biopsies are an active part of the pathologist’s day and have increased in the past few years as endoscopic screening has become more commonplace. This new full-color Second Edition of Biopsy Interpretation of the Gastrointe
Описание: Providing an in-depth summary of the molecular aspects of carcinogenesis, this text comprehensively covers chemical, radiation, and viral carcinogenesis - from animal and human test data to metabolism and DNA binding. It covers organic and metal carcinogenesis related to lung, breast, prostate, skin, liver, colon, brain, and thyroid cancers. The book explores the human implications of data regarding oncogenesis of transgenic and knockout mice and rats. It also covers the genomics and proteomics of chemoprevention, risk and exposure assessments, and regulation of carcinogens. Molecular Carcinogenesis and the Molecular Biology of Human Cancer is an ideal text for graduate courses in cancer.
Автор: George G. Chen; Paul B.S. Lai (Eds.) Название: Apoptosis in Carcinogenesis and Chemotherapy ISBN: 1402095961 ISBN-13(EAN): 9781402095962 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: Aims to provide information on apoptotic processes involved in major neoplastic diseases and their translations into anti-cancer strategies. This book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer.
Описание: Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.
Описание: First published in 1992, this volume provides a systematic survey of the dibenzanthracenes and of their chemical, physiochemical and biological properties. The carcinogenic potential of the dibenzanthracenes - an important subclass of polycyclic aromatic hydrocarbons - has been extensively studied and documented since their identification as animal skin carcinogens was first demonstrated in the 1930s. the volume treats the nomenclature, the chemical and physical properties and the synthesis and preparation of the five principal isomers of the dibenzanthracenes series: dibenz (a, h),- dibenz (a, c), -dibenz (aj) anthracene, benzo(a)naphthacene and pentacene. Other chapters are devoted to their occurrence and analysis in the environment, in industrial processes and effluents, and in foodstuffs. The second part addresses their biological activity and reviews the metabolism, cellular interactions, toxicology mutagenicity and carcinogenicity of the dibenzanthracenes. The final chapter is devoted to structure-activity relationships in this class of aromatic compounds. This is the first comprehensive account of this important group of environmental pollutants and carcinogens. It will be of interest to all scientists studying carcinogenesis, and the mutagenicity and toxicology of environmental pollutants.K
Автор: Jonathan J. Li; Sara A. Li; Suresh Mohla; Henri Ro Название: Hormonal Carcinogenesis V ISBN: 1441923993 ISBN-13(EAN): 9781441923998 Издательство: Springer Рейтинг: Цена: 32225 р. Наличие на складе: Поставка под заказ.
Описание: Information gathered from cell-free systems, cell cultures, animal models, and human studies, together provide important insights to our understanding of hormonal cancer causation, development, and prevention; The emerging fields of colon, lung, and pancreatic cancers in relation to hormones are examined.
Описание: A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.
Описание: Development and progression of gastrointestinal disease involves inflammatory, vascular, fibrogenetic and immune reactions accompanied by deregulation of cellular growth and death often resulting in cancer of the organs affected. This book, the proceedings of Falk Symposium 132 on `Disease Progression and Carcinogenesis in the Gastrointestinal Tract', held in Freiburg, Germany, October 9-10, 2002, addresses these various cellular processes in five sections in order to build up a broad pathogenic concept of gastrointestinal disease, purposely going beyond organ-specific research. Each section combines experts in the various fields of molecular medicine together with clinical scientists in order to stimulate interdisciplinary discussion. In addition, clinical chapters focus on new findings in both diagnostics and therapeutics.
Автор: Penning Название: Chemical Carcinogenesis ISBN: 1617379948 ISBN-13(EAN): 9781617379949 Издательство: Springer Рейтинг: Цена: 23747 р. Наличие на складе: Поставка под заказ.
Описание: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the stealth-like properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Автор: Clayson; David B. Название: Toxicological Carcinogenesis ISBN: 1566705088 ISBN-13(EAN): 9781566705080 Издательство: Informa Рейтинг: Цена: 12599 р. Наличие на складе: Нет в наличии.
Описание: Written by an expert with more than fifty years experience, Toxicological Carcinogenesis presents a balanced and authoritative treatment of the issues. It provides a summary of current information available on chemicals that induce cancer and an appendix containing bibliographic references, making the text easy to use as a reference. The book fills a gap in the literature by including just enough background information to give a complete general overview of the subject. It explores the emerging debates related to the potential chemical causes of cancer and it explains the potential problems caused by possible misinformation about chemical carcinogenesis.
Описание: Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.
Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. The book posits that the autocatalyzed progression of aneuploidy is carcinogenesis. The clarity and unifying simplicity of the theory of chromosomal imbalance has the potential to fundamentally alter the course of cancer research, prevention, diagnosis and treatment.
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