Îïèñàíèå: Succeed in your course with the most comprehensive source on pharmaceutical dosage forms and drug delivery systems available today. Reflecting the CAPE, APhA, and NAPLEX® competencies, this trusted resource covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms and the clinical application of the various dosing forms in patient care. The 10th edition features a dynamic new full color design, new coverage of prescription flavoring, and additional coverage of expiration dates. See pharmaceutical concepts in action through the two case studies (one pharmaceutical and one clinical) in each dosing forms chapter. Practice applying material using the group and individual activities in Applying the Principles and Concepts sections in every chapter. Master important underlying pharmaceutical principles through Physical Pharmacy Capsules. Extend your learning beyond the book with the online glossary and the online quiz bank that features 300 NAPLEX-style questions.Focus on what’s important with Chapter Objectives that highlight key material you need to master.
Îïèñàíèå: Suitable for pharmaceutics courses, this book provides a comprehensive source on pharmaceutical dosage forms and drug delivery systems. It features content that coincides with the CAPE, APhA, and NAPLEX competencies. It offers coverage that incorporates various dosage forms on the market and those in the US Pharmacopoeia-National Formulary.
Îïèñàíèå: 1 Duncan, H. Ringsdorf, R. Satchi-Fainaro: Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities.- 2 P.K. Dhal, S.R. Holmes-Farley, C.C. Huval, T.H. Jozefiak: Polymers as Drugs.- 3 R.J. Amir, D. Shabat: Domino Dendrimers.- 4 G. Pasut, F.M. Veronese: PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates.- E. Wagner, J. Kloeckner: Gene Delivery Using Polymer Therapeutics.-
Àâòîð: Sebti Saïd M., Hamilton Andrew D. Íàçâàíèå: Farnesyltransferase Inhibitors in Cancer Therapy ISBN: 0896036294 ISBN-13(EAN): 9780896036291 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 16719 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Àâòîð: Giordano Antonio, Soprano Kenneth J. Íàçâàíèå: Cell Cycle Inhibitors in Cancer Therapy ISBN: 0896039307 ISBN-13(EAN): 9780896039308 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 23931 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Àâòîð: Adams Julian Íàçâàíèå: Proteasome Inhibitors in Cancer Therapy ISBN: 1588292509 ISBN-13(EAN): 9781588292506 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 23931 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (Velcadeâ„¢) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.
Àâòîð: Gradon Leon, Marijnissen J.C. Íàçâàíèå: Optimization of Aerosol Drug Delivery ISBN: 1402016514 ISBN-13(EAN): 9781402016516 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 30201 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
Àâòîð: Lu D. Robert, Øie Svein Íàçâàíèå: Cellular Drug Delivery / Principles and Practice ISBN: 1588292541 ISBN-13(EAN): 9781588292544 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 19532 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology.
A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers:
Commercial development of devices and products based on transdermal physical enhancement technologies
Selecting optimal enhancement technology for a specific drug molecule using case studies
Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection
Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines
Practical information on experimental procedures and challenges related to skin irritation and safety issues
Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.
