Описание: Leading physician scientists and noted researchers review novel methods for determining the etiology of a variety of lung cancers and present readily reproducible techniques for examining the associated multitude of genetic abnormalities. The methods make it possible to detect these alterations at the cellular, DNA, and protein levels, to study the development of lung cancer in vitro and in vivo-either in situ or in the form of metastases, and to test targeted therapies with detailed model systems. An animal models section gives explicit instructions for setting up and testing these systems, which are rarely described in the literature.
Описание: Discusses the subjects of diagnosis, therapy, therapy assessment, and prognosis of lung and prostate cancer. This book presents a comprehensive treatise on various aspects of Lung and Prostate cancer, including diagnosis, treatments and prognosis.
Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.
Описание: Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
Описание: This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
Описание: Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists.
Описание: Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets, and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.
Описание: Prostate cancer is the second leading cause of death in men and its progression is highly dependent on androgens and androgen receptors. However, even
with treatment, eventually most prostate cancers progress. Studies of the mechanisms behind this progression leads to advances in treatments for androgen-related diseases.
Our book discusses recent prostate cancer research, which includes the following topics: immunotherapy and chemotherapy; radiation, gene, hormonal, and androgen ablation
therapies; basic mechanisms behind prostate cancer growth; how mechanisms can be used to treat prostate cancer; and research in newly developed mouse model systems. This
book should be of interest as both a study guide and research reference to students, basic scientists, and clinicians.
Описание: Explores cancer micro environments and host interactions. This book is suitable for clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees).
Описание: One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of drug resistance by the cancer cells. This book covers the functional consequences of endocrine resistance in breast cancer with an emphasis on the applications of novel drug combinations that may be utilized to circumvent resistance.
Описание: This book offers a progress report on efforts to meet the challenges faced by ovarian cancer patients and their doctors. It provides a current perspective on therapeutic developments as a partnership between laboratory-based and clinical-based researchers.
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