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Breast Cancer Research Protocols, Brooks Susan A., Harris Adrian



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Автор: Brooks Susan A., Harris Adrian
Название:  Breast Cancer Research Protocols
ISBN: 9781588291912
Издательство: Springer
Классификация:
ISBN-10: 158829191X
Обложка/Формат: Hardback
Страницы: 517
Вес: 1.38 кг.
Дата издания: 01.11.2005
Серия: Methods in Molecular Medicine
Язык: English
Иллюстрации: 64 black & white illustrations, 1 colour illustrat
Размер: 23.62 x 16.21 x 3.35
Читательская аудитория: Postgraduate, research & scholarly
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Дополнительное описание: Формат: 229x152
Илюстрации: 64
Круг читателей: Clinical researchers working in hospital and academic laboratories
Ключевые слова:
Язык: eng





Writing Clinical Research Protocols,

Автор: Evan DeRenzo
Название: Writing Clinical Research Protocols,
ISBN: 0122107519 ISBN-13(EAN): 9780122107511
Издательство: Elsevier Science
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Цена: 6809 р.
Наличие на складе: Поставка под заказ.

Описание: Intended for clinical researchers, this book provides a foundation for improving skills in the understanding of ethical requirements in the design and conduct of clinical research. It includes practical information on ethical principles in clinical research, designing appropriate research studies, writing consent and assent documents.

Metastasis Research Protocols

Автор: Brooks Susan A., Schumacher Udo
Название: Metastasis Research Protocols
ISBN: 0896036154 ISBN-13(EAN): 9780896036154
Издательство: Springer
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Цена: 11544 р.
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Описание: Metastasis Research Protocols describes in detail all the methods needed to investigate why and how metastasis occurs. Volume I presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. Volume I focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, differential display. Volume II presents a comprehensive collection of established and leading-edge techniques for examining metastatic behavior in vitro and whole animal models. Methods are provided for the separation of cell lines with high and low metastatic potential, along with assay systems to test defined aspects of the metastatic cascade. These systems include cell migration assays, assays for matrix degradation enzymes, basement membrane degradation assays, adhesion assays, and assays of angiogenesis. The detailed descriptions of animal models for metastasis cover the use of immunodeficient animals, syngenic and transgenic models, and orthotopic models of metastasis.

Metastasis Research Protocols

Автор: Brooks Susan A., Schumacher Udo
Название: Metastasis Research Protocols
ISBN: 0896036103 ISBN-13(EAN): 9780896036109
Издательство: Springer
Рейтинг:
Цена: 10389 р.
Наличие на складе: Поставка под заказ.

Описание: Metastasis Research Protocols describes in detail all the methods needed to investigate why and how metastasis occurs. Volume I presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. Volume II presents a comprehensive collection of established and leading-edge techniques for examining metastatic behavior in vitro and whole animal models. Methods are provided for the separation of cell lines with high and low metastatic potential, along with assay systems to test defined aspects of the metastatic cascade. These systems include cell migration assays, assays for matrix degrading enzymes, basement membrane degrading assays, adhesion assays, and assays of angiogenesis. The detailed descriptions of animal models of metastasis cover the use of immunodeficient animals, syngenic and transgenic models, and orthotopic models of metastasis.

Designing clinical research

Автор: Hulley
Название: Designing clinical research
ISBN: 1608318044 ISBN-13(EAN): 9781608318049
Издательство: Lippincott Williams & Wilkins
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Цена: 9900 р.
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Описание: Designing Clinical Research has been extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing. New to this edition: Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirements Color format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary

Methods in Mammary Gland Biology and Breast Cancer Research

Автор: Ip
Название: Methods in Mammary Gland Biology and Breast Cancer Research
ISBN: 0306463970 ISBN-13(EAN): 9780306463976
Издательство: Springer
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Цена: 23747 р.
Наличие на складе: Поставка под заказ.

Описание: This book is a bench manual that provides in one volume all the important and unique technologies necessary to studies of mammary gland biology and breast cancer. The chapters are written by experts in each area with an emphasis on nitty-gritty details that are key points for the successful use of a method. Sections include in vivo model systems, special techniques for in vivo studies, in vitro model systems, and molecular analysis and gene transfer techniques.

Reviews and Protocols in DT40 Research / Subcellular Biochemistry

Автор: Buerstedde Jean-Marie, Takeda Shunichi
Название: Reviews and Protocols in DT40 Research / Subcellular Biochemistry
ISBN: 1402048955 ISBN-13(EAN): 9781402048951
Издательство: Springer
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Цена: 30223 р.
Наличие на складе: Поставка под заказ.

Описание: Research is fast paced and advances in RNA interference have recently opened up new opportunities for genetic experiments in human cell lines. However, the possibility to easily modify the genome still remains a powerful tool to investigate the function of coding and regulatory sequences in the vertebrate genome. DT40 has never been a quick and easy road to fame. It would be unfair to blame this on DT40 as it has proven to be a reliable and robust companion with fast doubling time, easy clonability and a relatively stable karyotype. If this model system is going to flourish over the next 15 years, it will be thanks to ingenious and original researchers. They may feel as if they work outside the mainstream, but they can take heart by the fact that only the clever exploitation of diversity and conservation makes biological research both elegant and rewarding. It is with this in mind that the DT40 handbook has been conceived and written. This book provides an up to date overview of the different facets of research, and also intends to help newcomers get started and avoid looming pitfalls. The collection of protocols which have been kindly provided by a number of laboratories will be particularly useful in this regard.

Автор: Kieber-Emmons Thomas
Название: Cancer Vaccine Protocols
ISBN: 1588292711 ISBN-13(EAN): 9781588292711
Издательство: Springer
Цена: 11544 р.
Наличие на складе: Поставка под заказ.

Gene Therapy of Cancer / Methods and Protocols

Автор: Walther Wolfgang, Stein Ulrike
Название: Gene Therapy of Cancer / Methods and Protocols
ISBN: 0896038432 ISBN-13(EAN): 9780896038431
Издательство: Springer
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Цена: 19056 р.
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Описание: Wolfgang Walther and Ulrike Stein survey the rapidly evolving field cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, its readily reproducible, cutting-edge methods constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.

Recombinant Antibodies for Cancer Therapy / Methods and Protocols

Автор: Welschof Martin, Krauss JГјrgen
Название: Recombinant Antibodies for Cancer Therapy / Methods and Protocols
ISBN: 0896039188 ISBN-13(EAN): 9780896039186
Издательство: Springer
Рейтинг:
Цена: 21944 р.
Наличие на складе: Поставка под заказ.

Описание: In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschoff and JГјrgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of novel anticancer therapeutics based on recombinant antibody technology. These readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.

Renal Cancer / Methods and Protocols

Автор: Mydlo Jack H.
Название: Renal Cancer / Methods and Protocols
ISBN: 0896038289 ISBN-13(EAN): 9780896038288
Издательство: Springer
Рейтинг:
Цена: 17901 р.
Наличие на складе: Поставка под заказ.

Описание: Jack H. Mydlo, MD, and a panel of leading clinicians and researchers review every aspect of the latest surgical, medical, and immunological techniques that can be used in the diagnosis and treatment of renal cancer. These broadly experienced investigators also present a practical account of their best basic research methods, including the use of reverse transcriptase PCR combined with genomic hybridization, cadherin, and metalloproteinase expression to reveal important factors in the detection, staging, aggressiveness, and treatment of this disease. Gene therapy, the generation of monoclonal antibodies, and the use of interferon alpha, GM-CSF, and IL-6 are also discussed. Comprehensive and pioneering, Renal Cancer: Methods and Protocols offers urologists, medical oncologists, laboratory investigators, and pathologists a practical collection of the major cutting-edge techniques and therapies for renal cancer today, together with a view of the highly promising future of gene therapy.

Checkpoint Controls and Cancer / Volume 2: Activation and Regulation Protocols

Автор: SchГ¶nthal Axel H.
Название: Checkpoint Controls and Cancer / Volume 2: Activation and Regulation Protocols
ISBN: 1588295001 ISBN-13(EAN): 9781588295002
Издательство: Springer
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Цена: 16746 р.
Наличие на складе: Поставка под заказ.

Описание: Prestigious researchers from ten different countries present readily reproducible experimental protocols to study the molecular components of checkpoint controls and their regulation. Described in step-by-step detail, these cutting-edge techniques offer novel approaches, such as the use of genome databases and siRNA, to analyzing how cells of the human body can escape proper surveillance to grow into a tumor. Additional experimental methods are provided for the manipulation of checkpoint pathways and the analysis of the resulting consequences for the cellular phenotype. An earlier first volume, Reviews and Model Systems, comprehensively reviews the complexities of checkpoint controls and the model systems needed to study them.

Cancer Cell Signaling / Methods and Protocols

Автор: Terrian David M.
Название: Cancer Cell Signaling / Methods and Protocols
ISBN: 1588290751 ISBN-13(EAN): 9781588290755
Издательство: Springer
Рейтинг:
Цена: 16746 р.
Наличие на складе: Поставка под заказ.

Описание: A collection of readily reproducible experimental methods for studying the subversion of normal cell signaling that leads to cancer. Presented in step-by-step detail to ensure successful results, the methods include proven techniques for the investigation of apoptosis and cell death, complementary protocols for manipulating and/or monitoring oncogenic signals in cancer cells, and techniques for studying protein-protein interactions. A detailed protocol for capturing pure samples of malignant cells from frozen tissue specimens and two alternative techniques for analyzing their genomic DNA is also described.


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