Контакты/Проезд  Доставка и Оплата Помощь/Возврат
История
  +7(495) 980-12-10
  пн-пт: 10-18 сб,вс: 11-18
  shop@logobook.ru
   
    Поиск книг                    Поиск по списку ISBN Расширенный поиск    
Найти
  Зарубежные издательства Российские издательства  
Авторы | Каталог книг | Издательства | Новинки | Учебная литература | Акции | Хиты | |
 

Techniques in Prion Research, Lehmann Sylvain, Grassi Jacques


Варианты приобретения
Цена: 18086.00р.
Кол-во:
Наличие: Поставка под заказ.  Есть в наличии на складе поставщика.
Склад Америка: Есть  
При оформлении заказа до:
Ориентировочная дата поставки:
При условии наличия книги у поставщика.

Добавить в корзину
в Мои желания

Автор: Lehmann Sylvain, Grassi Jacques
Название:  Techniques in Prion Research
Перевод названия: Техники в исследовании прионов
ISBN: 9783764324155
Издательство: Birkhauser Verlag AG
Классификация:




ISBN-10: 3764324155
Обложка/Формат: Hardcover
Страницы: 219
Вес: 0.60 кг.
Дата издания: 31.01.2004
Серия: Methods and Tools in Biosciences and Medicine
Язык: English
Размер: 17.78 x 23.88 x 1.73
Поставляется из: Германии
Описание: Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin.Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs.This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods.Features:Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res)Animal Models of TSEsCell Culture Models of TSEsPrPsc ImmunohistochemistryWestern Immunoblotting TechniquesAntibody Production and ELISATSE Strain Typing in MiceBiosafety and Decontamination ProceduresCell-free Conversion of Prion ProteinsCytotoxicity of PrP PeptidesCyclic Amplification of Prion Protein MisfoldingPrion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin.Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs.This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods.Abbreviations.- Transmissible Spongiform Encephalopathies or Prion Diseases (General Introduction).- Purification of PrPC. Purification of the Pathological Isoform of Prion Protein (PrPsc or PrP-res) from Transmissible Spongiform Encephalopathy-affected Brain Tissue.- Rapid Procedure for Purification and Renaturation of Recombinant PrP Protein.- Animal Models of Transmissible Spongiform Encephalopathies: Experimental Infection, Observation and Tissue Collection.- Cell Culture Models of TSEs.- PrPsc Immunohistochemistry. Western Immunoblotting Techniques for the Study of Transmissible Spongiform Encephalopathies. Antibody Production and ELISA, Diagnosis of TSEs, General Considerations.- TSE Strain Typing in Mice. Biosafety and Decontamination Procedures.- Cell-free Conversion of Prion Proteins.- Cytotoxicity of PrP Peptides.- Cyclic Amplification of Prion Protein Misfolding. Guide to Solutions.- Guide to Protocols.- Index
Дополнительное описание: Круг читателей: Researchers and clinicians; scientific libraries; pharmaceutical industry, postgraduate students
Язык: eng




WHO Classification of Tumours Pathology & Genetics of Tumours of the Soft Tissue & Bone

Название: WHO Classification of Tumours Pathology & Genetics of Tumours of the Soft Tissue & Bone
ISBN: 9283224132 ISBN-13(EAN): 9789283224136
Издательство: WHO Press
Рейтинг:
Цена: 8000.00 р.
Наличие на складе: Есть (4 шт.)
Описание: This book is an authoritative, concise reference, prepared by 147 authors from 28 countries. It contains more than 800 colour photographs, numerous MRIs, ultrasound images, CT scans, charts and approximately 2000 references. Diagnostic criteria, pathological features and associated genetic alterations are described in a strictly disease-oriented manner.

Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex dis ribution, location, clinical signs and symptoms, pathology, genetics and predictive factors.

Prion Diseases.1997

Автор: Collinge
Название: Prion Diseases.1997
ISBN: 0198547897 ISBN-13(EAN): 9780198547891
Издательство: Oxford Academ
Цена: 2772.00 р.
Наличие на складе: Поставка под заказ.

Описание: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists, veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide an up-to-date and authoritative summary of the field.

Clinical Diabetes Research: Methods and Techniques

Автор: Roden
Название: Clinical Diabetes Research: Methods and Techniques
ISBN: 0470017287 ISBN-13(EAN): 9780470017289
Издательство: Wiley
Рейтинг:
Цена: 25336.00 р.
Наличие на складе: Поставка под заказ.

Описание: Clinical Diabetes Research: Methods and Techniques summarizes established state-of-the art-techniques and describes the new technologies and their role in clinical diabetes research.

World cancer report 2008

Автор: International Agency For Research On Cancer
Название: World cancer report 2008
ISBN: 9283204239 ISBN-13(EAN): 9789283204237
Издательство: WHO Press
Рейтинг:
Цена: 8276.00 р.
Наличие на складе: Поставка под заказ.

Описание: It is estimated that there will be over 12 million people diagnosed with cancer this year. Hardly any family has not been touched by cancer, and when cancer hits it can hit hard. The burden on society caused by cancer is immense, not only in terms of the human suffering of patients and their relatives and friends, but the cost of cancer in economic terms. The strain cancer produces on health professionals and health systems is substantial and growing rapidly.

The World Cancer Report 2008 provides a unique global view of cancer and documents many important features of the global situation. The global cancer burden doubled in the last thirty years of the twentieth century, and it is estimated that this will double again between 2000 and 2020 and nearly triple by 2030. Until recently, cancer was considered a disease of westernized, industrialized countries. Today the situation has changed dramatically with the majority of the global cancer burden now found in low- and medium-resource countries. The greatest impact of this coming increase will fall on the low- and medium-resource countries, which frequently have a limited health budget and a high background level of communicable disease. Cancer treatment facilities are not universally available and life-saving therapies are frequently unavailable.

The rapid increase in the cancer burden represents a real crisis for public health and health systems worldwide. A major issue for many countries, even among high-resource countries, will be how to find sufficient funds to treat all cancer patients effectively and provide palliative, supportive and terminal care for the large numbers of patients--and their relatives--who will be diagnosed in the coming years.

The World Cancer Report 2008 provides a comprehensive overview of cancer for all those working in the field of health-care and research, and the general reader as well. It presents information on cancer patterns, diagnosis, causes and prevention concisely, clearly outlining the growing public health crisis. Simultaneously, there is a clear message of hope: although cancer is a great and growing devastating disease, it is largely preventable.

Current priorities for global cancer control must include a focus on low- and medium-resource countries and the identification, delivery and evaluation of effective cancer control measures. Prevention research is of overwhelming importance. Translational research in its broadest sense is of paramount importance to cancer control, covering the spectrum from translating cutting-edge scientific discovery into new approaches to cancer treatment to translating knowledge of cancer risk factors into changes in population behavior.

Translational Research in Audiology, Neurotology, and the Hearing Sciences

Автор: Le Prell
Название: Translational Research in Audiology, Neurotology, and the Hearing Sciences
ISBN: 3319408461 ISBN-13(EAN): 9783319408460
Издательство: Springer
Рейтинг:
Цена: 19564.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from “bedside to bench to bedside”, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.

Designing clinical research

Автор: Hulley
Название: Designing clinical research
ISBN: 1608318044 ISBN-13(EAN): 9781608318049
Издательство: Lippincott Williams & Wilkins
Рейтинг:
Цена: 12355.00 р.
Наличие на складе: Поставка под заказ.

Описание: Designing Clinical Research has been extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing. New to this edition: Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirements Color format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary

Mixed Methods in Health Sciences Research: A Practical Primer

Автор: Curry Leslie A., Nunez-Smith Marcella
Название: Mixed Methods in Health Sciences Research: A Practical Primer
ISBN: 1483306771 ISBN-13(EAN): 9781483306773
Издательство: Sage Publications
Рейтинг:
Цена: 9504.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Packed with illustrations from the health sciences literature, the book shows students how to design, conduct, review, and use mixed methods research findings. Throughout the book, real-world examples and insights from mixed methods researchers provide unique perspectives on every aspect of mixed methods research.


ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
   В Контакте     В Контакте Мед  Мобильная версия