Автор: Gupta Sudhir, Butcher Eugene, Paul William E.
Название: Lymphocyte Activation and Immune Regulation IX / Homeostasis and Lymphocyte Traffic
ISBN: 030647395X ISBN-13(EAN): 9780306473951
Издательство: Springer
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Цена: 16500 р.
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Описание: During the past five years major progress has been made in understanding the basic mechanisms of lymphocyte homeostasis and in the developmental relationship between different memory T subsets and their traffic patterns and functional significance. This volume highlights the current concepts of lymphocyte development, factors regulating lymphocyte trafficking and development, and specialized characteristics and functional properties of naive and memory subsets. This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented. Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans. Novel methods of visualization of immune cells and immune systems are reviewed in Section III. This includes tracking of dendritic cells in vivo, monitoring arterial smooth muscle-specific T cells in the inflamed vasculature, imaging of molecular migrations in immune synapses, and visualization of various immune cells in intact lymphoid tissues by two photon confocal imaging. This volume should be of interest to immunologists, molecular biologists, microbiologists, pathologists, academic physicians, cell biologists, and scientists and clinicians interested in vaccine development.

Автор: Gupta Sudhir
Название: Mechanisms of Lymphocyte Activation and Immune Regulation VIII / Autoimmunity 2000 and Beyond
ISBN: 0306465701 ISBN-13(EAN): 9780306465703
Издательство: Springer
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Цена: 13612 р.
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Описание: Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

Автор: Kearse Kelly P.
Название: T Cell Protocols / Development and Activation
ISBN: 0896038106 ISBN-13(EAN): 9780896038103
Издательство: Springer
Цена: 7421 р.
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Описание: Kelly P. Kearse and a panel of laboratory experts describe the step-by-step execution of a wide variety of basic and specialized techniques for the study of T cell developmental biology and of their subsequent activation. Readily reproducible, the techniques are explained concisely, but in such detail that they are suitable for both the novice and experienced investigator. Coverage includes treatment of both fundamental and novel experimental protocols for the analysis of the role T cells play in immune function and in the prevention and cure of human diseases. Practical and timely, T Cell Protocols: Development and Activation offers basic scientists and clinical investigators a valuable compendium of key protocols that will improve skills with existing methods, as well as afford rapid mastery of powerful new techniques.

Автор: Moody D.B.
Название: T Cell Activation by CD1 and Lipid Antigens
ISBN: 3540695109 ISBN-13(EAN): 9783540695103
Издательство: Springer
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Цена: 13199 р.
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Описание: There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.

Автор: Gupta Sudhir, Paul William E. , Steinman Ralph
Название: Mechanisms of Lymphocyte Activation and Immune Regulation X / Innate Immunity
ISBN: 0387241884 ISBN-13(EAN): 9780387241883
Издательство: Springer
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Цена: 18893 р.
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Описание: Mechanisms of Lymphocyte Activation and Immune Regulation X: Innate Immunity is the proceedings of the Xth International Conference on Mechanisms of Lymphocyte Activation and Immune Regulation: Innate Immunity, held February 6-8, 2004 in Newport Beach, California. It is the tenth volume of its kind to appear in the series Advances in Experimental Medicine and Biology. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.

Автор: Gander Bruno
Название: Antigen Delivery Systems: Immunological And Technological Issues (Drug Targeting & Delivery)
ISBN: 9057022672 ISBN-13(EAN): 9789057022678
Издательство: Informa
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Цена: 8474 р.
Наличие на складе: Нет в наличии.

Описание: This text presents an up-to-date overview of recent developments in this field, reviews new trends in vaccine development programs, and emphasizes the requirements and importance of varied vaccine delivery systems.

Автор: Perez H.D., Mitrovic B., Baron Van Evercooren A.
Название: Opportunities and Challenges of the Therapies Targeting CNS Regeneration
ISBN: 3540240829 ISBN-13(EAN): 9783540240822
Издательство: Springer
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Цена: 13612 р.
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Описание: The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Автор: Singh Harinder, Grosschedl Rudolf
Название: Molecular Analysis of B Lymphocyte Development and Activation
ISBN: 3540230904 ISBN-13(EAN): 9783540230908
Издательство: Springer
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Цена: 18893 р.
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Описание: The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation.

Автор: Branch D. Moody
Название: T Cell Activation by CD1 and Lipid Antigens
ISBN: 3642089062 ISBN-13(EAN): 9783642089060
Издательство: Springer
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Цена: 18893 р.
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Описание: There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens.

Автор: Sudhir Gupta
Название: Mechanisms of Lymphocyte Activation and Immune Regulation XI
ISBN: 0387465278 ISBN-13(EAN): 9780387465272
Издательство: Springer
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Цена: 19275 р.
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Описание: Features the proceedings that highlight developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Автор: B?ldicke
Название: Protein Targeting Compounds
ISBN: 3319328042 ISBN-13(EAN): 9783319328041
Издательство: Springer
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Цена: 13107 р.
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Описание: This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions.Key aspects of this book are:- Selection strategies for monoclonal and recombinant human antibodies- Selection strategies for ER intrabodies, peptides and aptamers- Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology- Antibodies for cancer therapy and inhibitors of angiogenesis.The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.

Автор: Novartis Foundation
Название: Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease, No. 271
ISBN: 0470013125 ISBN-13(EAN): 9780470013120
Издательство: Wiley
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Цена: 13184 р.
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Описание: The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.