Experimental Models of Multiple Sclerosis, Lavi Ehud, Constantinescu Cris S.
Автор: Cohen Название: Multiple Sclerosis Therapeutics ISBN: 0521766273 ISBN-13(EAN): 9780521766272 Издательство: Cambridge Academ Рейтинг: Цена: 25473 р. Наличие на складе: Есть (1 шт.) Описание: This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.
Описание: Differentiating multiple sclerosis (MS) from alternative demyelinating diseases of the central nervous system and systemic medical conditions that mimic MS is challenging. A simple three-step approach is used in this text to guide readers through clinical cases to define MS and rule out competing causes. Case presentations are used to illustrate simple pearls and other clues that will aid clinicians in assessing and managing difficult clinical situations. The chapters are organized to reflect challenges regarding specific anatomical territories affected by MS and its mimickers, namely evaluation of impairment in the optic nerves, brain, brainstem, cerebellum, and spinal cord. Specific examples are used where the author or the treating physician was correct or incorrect in investigating or managing a particular question. The wisdom of hindsight thus generated becomes an invaluable and enduring lesson. The text is written in a coaching style, buttressed by the strong pedagogic wisdom of the author.
Описание: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".
Описание: Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides the scientific basis of multiple sclerosis including etio
Описание: Controversy still exists regarding how early disease-modifying agents (DMA) should be commenced and whether all patients with relapsing-remitting MS should in fact be treated. With their novel, multifaceted approach to basic science, the authors of this book offer help to clinicians and hope to patients.
Описание: Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. . Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.
Автор: Alireza Minagar Название: Multiple Sclerosis ISBN: 012800763X ISBN-13(EAN): 9780128007631 Издательство: Elsevier Science Рейтинг: Цена: 13167 р. Наличие на складе: Поставка под заказ.
Описание: . Multiple Sclerosis: A Mechanistic View provides a unique view of the pathophysiology of multiple sclerosis (MS) and related disorders. As the only book on the market to focus on the mechanisms of MS rather than focusing on the clinical features and treatment of the disease, it describes the role of genetic and environmental factors in the pathogenesis of MS, the role of specific cells in the pathophysiology of the disease, and the pathophysiology of inflammatory and neurodegenerative disorders related to MS. . The book provides discussion of neurodegeneration and neuroregeneration, two critical emerging areas of research, as well as detailed discussion of the mechanisms of action of the approved and investigational drugs for treatment of MS and the emerging role of magnetic resonance spectroscopy (MRI) in investigations into MS. . It is the only book on the market to offer comprehensive coverage of the known mechanisms of MS and related diseases, and contains contributions from physicians and researchers who are worldwide experts in the field of study.
Автор: Stephen Waxman Название: Multiple Sclerosis As A Neuronal Disease, ISBN: 0127387617 ISBN-13(EAN): 9780127387611 Издательство: Elsevier Science Рейтинг: Цена: 23100 р. Наличие на складе: Поставка под заказ.
Описание: Examines the role of neurons in Multiple Sclerosis (MS) and the changes that occur in neurons as a result of MS. This book explains the basis for symptom production, remission and progress in MS. It brings together information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of MS.
Описание: This comprehensive resource examines all aspects of the care of the patient with multiple sclerosis. It focuses on the themes of: the importance of patient-centred nursing; comprehensive assessment of the person with MS; the wide variation in the course of MS; and the role of the nurse.
Описание: "This patient-friendly chart defines multiple sclerosis (MS) and details signs and symptoms and prevention and management techniques. The chart also shows the effect of MS on a normal nerve cell, comparing a normal myelin sheath to one damaged from the disease.
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