Описание: An accessible and easy-to-read text, this is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications, and potential future developments, making it indispensable for pharmaceutical students, scientists and researchers. It covers how to optimize therapeutic efficacy; drug absorption, unwanted distribution and premature inactivation / elimination; attempts to minimize toxicity or alter immunogenicity; achieving rate-controlled drug release and effective drug targeting; routes of delivery; and technologies such as biosensors, microchips, stimuli-sensitive hydrogels, and plasmid-based gene therapy.
Описание: Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to provide a firm foundation to the subject.
Автор: Giezen Mark van der Название: Protein Targeting Protocols ISBN: 1588297020 ISBN-13(EAN): 9781588297020 Издательство: Springer Рейтинг: Цена: 14492 р. Наличие на складе: Поставка под заказ.
Описание: In this highly anticipated update of the extremely successful Protein Targeting Protocols, experts from around the world provide the latest protocols on for isolating different organelles and the localization of particular proteins using a variety of methods such as light, confocal, and electron microscopy. Unlike the first edition, however, this volume places emphasis on protein targeting of cellular compartments in both prokaryotic and eukaryotic systems.Authoritative and state-of-the-art, Protein Targeting Protocols, Second Edition, provides useful techniques that will aid scientists working with a variety of organisms.
Описание: This text presents an up-to-date overview of recent developments in this field, reviews new trends in vaccine development programs, and emphasizes the requirements and importance of varied vaccine delivery systems.
Описание: Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. . The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. . By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner.
Описание: G. E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.
Автор: Muzykantov Vladimir R., Torchilin Vladimir P. Название: Biomedical Aspects of Drug Targeting ISBN: 1402072325 ISBN-13(EAN): 9781402072321 Издательство: Springer Рейтинг: Цена: 21412 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book includes general principles of drug targeting, targeting in the cardiovascular system, tumor targeting, brain targeting, miscellaneous targeting and novel approaches for targeting (new horizons). It is designed in a course-like fashion: from more general and simple to more specific and complex material. This framework will help even unfamiliar readers to learn new topics and navigate in the text. Although the book is aimed primarily at industrial and academic pharmacologists and drug discovery researchers, its design will make the book useful for advanced level graduate students. The book focuses on ligand-mediated drug targeting strategies, with additional chapters on general aspects of drug delivery that are of paramount importance in drug targeting (biological barriers, stealth technologies). Included are topics on targeting of genetic materials important in the biomedical context of the ligand-mediated targeting.
Автор: Schreier Hans Название: Drug Targeting Technology ISBN: 0824705807 ISBN-13(EAN): 9780824705800 Издательство: Informa Цена: 9888 р. Наличие на складе: Нет в наличии.
Описание: Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver!
This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inhalation delivery, and the development of original formulations that are matched by innovative device design.
Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways!
Containing over 1100 references to facilitate further study, Drug Targeting Technology
updates recent progress in oral and colonic targeting technology using pH- and enzyme-sensitive coating materials and novel polymer systems
shows how the systemic distribution of drugs can be modulated by lipid-based carriers taking alternative routes of transport, particularly lymph flow
details soft drugs that are rapidly metabolized to inactive and nontoxic metabolites and removed efficiently from the body
includes successful designs of virus-like liposomal delivery systems that offer the advantages of viral carriers
supplies examples of how viral delivery systems can be directed to cancer sites
and more! Suggesting harnessing biological processes as the ultimate approach to the delivery or expression of pharmacologically active agents, Drug Targeting Technology is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, surface, physical, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.
Автор: Nathan P. Colowick Название: Drug and Enzyme Targeting, Part A,112 ISBN: 0121820122 ISBN-13(EAN): 9780121820121 Издательство: Elsevier Science Рейтинг: Цена: 5138 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Hurtley Название: Protein Targeting.1996 ISBN: 0199635617 ISBN-13(EAN): 9780199635610 Издательство: Oxford Academ Рейтинг: Цена: 8847 р. Наличие на складе: Поставка под заказ.
Описание: Protein targeting is the study of how proteins synthesized in one part of the cell reach their ultimate destination. This book is a preview of the latest research, which has applications for understanding cancer, studying diseases due to faulty targeting, and genetic manipulation of microorganisms.
Описание: Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.Written while completing graduate work at California Institute of Technology.
Автор: Davidovich Название: Targeting Functional Centers of the Ribosome ISBN: 3642169309 ISBN-13(EAN): 9783642169304 Издательство: Springer Рейтинг: Цена: 8134 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
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