Uversky Vladimir N., Fink Anthony L. Protein Misfolding, Aggregation and Conformational Diseases / Part A: Protein Aggregation and Conformational Diseases 9780387259185

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Автор: Uversky Vladimir N., Fink Anthony L.
Название: Protein Misfolding, Aggregation and Conformational Diseases / Part A: Protein Aggregation and Conformational Diseases
Перевод названия: Деформация протеина , агрегация и конформационные болезни / часть А
ISBN: 9780387259185
Издательство: Springer
Классификация:

Иммунология

Биология и науки о жизни

Клеточная биология (цитология)

ISBN-10: 038725918X
Обложка/Формат: Hardback
Страницы: 419
Вес: 1.82 кг.
Дата издания: 2006
Серия: Protein Reviews
Язык: English
Иллюстрации: 14 black & white tables, biography
Размер: 23.62 x 16.00 x 2.79
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume fills the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. It is devoted to the general questions of conformational disorders and includes discussion of involvement of such common factors as molecular chaperones, oxidative damage, proteasome, glycosoaminoglycans, serum amyloid protein P and several others in the development of different disorders. Some experimental techniques applicable for the visualization of protein deposition in vivo and in vitro are also present.
Дополнительное описание: Формат: 235x155
Илюстрации: 58
Круг читателей: Biochemists, protein scientists, immunologists, pharmaceutical scientists, and molecular and cellular biologists
Ключевые слова: Protein
Misfolding
Aggregation
Conformational
Disease
Uversky
Язык: eng
Оглавление: Conformational prerequisites of amyloidogenesis.- The generic nature of protein folding and misfolding.- Relative importance of hydrophobicity, net charge and secondary structure propensities in prtein aggregation.- Cytotoxic intermediates in the fibrillation pathway: AB oligomers in Alzheimer's disease as a case study.- Glycosoaminoglycans, proteoglycans and conformational disorders.- Apolipoproteins in different amyloidoses.- Oxidative stress and protein deposition diseases.- Protein aggregation in crowded environment.- Chaperones and conformational disorders.- The aggresome: proteasomes, inclusion bodies and protein aggregation.- Protein aggregation/deposition and ion channel formation and membrane damage.- Visualization of protein deposits in vivo.- Visualization of protein deposits in vitro.- Animcal and cell models of human neurodegenerative disorders.- Index.

Protein Misfolding, Aggregation and Conformational Diseases / Part A: Protein Aggregation and Conformational Diseases, Uversky Vladimir N., Fink Anthony L.