Описание: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.
Описание: This exciting new book opens a window into the causes of debilitating neurological disorders, such as Parkinson's disease, CJD, and Huntington's disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, "Metals and Neurodegenerative Diseases: An Introductory Text" outlines the role of metals in human biology, in particular in the brain, and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.
Описание: Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, in
Описание: As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment.? Developing strategies to prevent degeneration of neurons and to promote a heal
Автор: Broderick Название: Bioimaging in Neurodegeneration ISBN: 1588293912 ISBN-13(EAN): 9781588293916 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: Bioimaging in Neurodegeneration fulfills the current need to bridge the diagnoses of neurodegenerative diseases with the technologies that enable their
accurate diagnoses. This book covers four clinical areas of neurodegenerative disease: Parkinson's, Alzheimer's, Epilepsy, and Leukodystrophy (White Matter), and the wide array of
devices used to diagnose them.
Автор: Harry Jean, Tilson Hugh A. Название: Neurodegeneration Methods and Protocols ISBN: 089603612X ISBN-13(EAN): 9780896036123 Издательство: Springer Рейтинг: Цена: 16746 р. Наличие на складе: Поставка под заказ.
Описание: An outstanding collection of detailed, state-of-the-art techniques for studying many aspects of nervous system cell biology. The methods span a multidisciplinary range of cellular and molecular approaches to both normal and injured nervous system function, and particularly to neurodegenerative processes. Included are basic RT-PCR techniques, cell culture systems, second-messenger signaling methods, and patch-clamp techniques. These powerful techniques will illuminate nervous system function, injury, degeneration, and the repair/regenerative process.
Автор: Stefanis Leonidas, Keller J.N. Название: The Proteasome in Neurodegeneration ISBN: 0387284990 ISBN-13(EAN): 9780387284996 Издательство: Springer Рейтинг: Цена: 20211 р. Наличие на складе: Поставка под заказ.
Описание: There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson`s and Alzheimer`s diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome.
Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.
Описание: Treatment of Parkinson`s Disease consists of a dopamine replacement strategy, but most patients experience intolerable drug-related side effects, and unacceptable levels of disability and mortality. This volume reviews the factors implicated in the pathogenesis of cell death in PD.
Описание: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Автор: Brown David R. Название: Neurodegeneration and Prion Disease ISBN: 0387239227 ISBN-13(EAN): 9780387239224 Издательство: Springer Рейтинг: Цена: 19634 р. Наличие на складе: Поставка под заказ.
Описание: This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cowвЂ™s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
Описание: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
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