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Radioionidation Reactions for Pharmaceuticals / Compendium for Effective Synthesis Strategies, Coenen Heinz H., Mertens John, Mazière Bernard



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: Coenen Heinz H., Mertens John, Mazière Bernard
 Radioionidation Reactions for Pharmaceuticals / Compendium for Effective Synthesis Strategies
: Springer
:
ISBN: 1402045603
ISBN-13(EAN): 9781402045608
/: Hardback
: 101
: 0.344 .
: 2006
: English
: Black & white illustrations
: 24.13 x 16.00 x 1.27
: Professional & vocational
: Compendium for effective synthesis strategies
: Link
:
:
: Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them. The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radio-iodination reactions.
: : 240x160
: Practitioners and researchers in Biomedical, (Radio-) Diagnostic and Clinical Laboratories; Nuclear chemists, biochemists and Biomedical researchers
:
: eng
: INTRODUCTION.- IODINE RADIONUCLIDES. Physical properties and areas of application. Radiochemical and radionuclidic purity. Specific radioactivity. Production of iodine radionuclides. Production of 120I. Production of 122I. Production of 123I. Production of 124I. Production of 125I. Production of 131I. References.- IODINATED RADIOPHARMACEUTICALS. Physico-chemical properties. Carbon-iodine bond. Bond distances. Energy, stability. Steric hindrance and electronic density. Lipophilicity. Pharmaceutical properties. Chemical and radiochemical purity. Stability in vitro and shelf-life. Pharmacological characteristics. Pharmaceutical considerations. References.-METHODS OF RADIOIODINATION. References. Nucleophilic substitution. General. Halogen exchange in aliphatic compounds. Isotopic exchange. Radioiodine-for-bromine exchange. Halogen exchange in aromatic compounds. Isotopic exchange. Radioiodine-for-bromine or -chlorine exchange. Copper assisted halogen exchange. Cu(I) assisted radioiodination. Cu(II) assisted radioiodination. Radioiodo-dediazonization. References. Electrophilic substitution. General considerations. Oxidising reagents. Iodine monohalide (ICl, IF). N-Chloroamides. Iodogen™ N-Halosuccinimides. Peracids. Other oxidants. Direct electrophilic radioiodination (radioiodo- deprotonation). Demetallation techniques (radioiodo-demetallation). Radioiodo-deboronation. Radioiodo-demetallation with group IV metals. Radioiodo-demetallation with mercury and thallium. References. Macromolecule labelling. Protein radioiodination. Direct radioiodination of proteins. Indirect radioiodination. Amine-reactive conjugates. Sulfhydryl-reactive conjugates. Carbohydrate-reactive conjugates. Nonspecific conjugates. Oligonucleotide radioiodination. References.- IODINATED RADIOPHARMACEUTICALS. Examples of nucleophilic labelling. Interhalogen exchange. Meta-iodobenzylguanidine (MIBG). RO 43-0463. Benzamides. Iomazenil. Other methods. IQNB. Iodoethylspiperone. Examples of electrophilic labelling. Direct iodination. Iodo-lisuride,- 3-Iodo-alpha-methyl-L-tyrosine (IMT),- IBZM. Radioiodo-demetallation. Fatty acid. Epidepride. beta-CIT. PE2I. Succinimide activated para-iodobenzoic acid. Iomazenil. MIBG. References.-EXPERT SYSTEM. General considerations. Activating effects of aromatic substituents. Aromatic nucleophilic substitution (SNAr). Aromatic electrophilic substitution (SEAr). Guidelines for radioiodination. Introduction. Examples.- COMPOUND: R91150. COMPOUND: IBZM.- Blank check-list.





Significant Pharmaceuticals  Reported in US Patents,

: Thomas F. DeRosa
: Significant Pharmaceuticals Reported in US Patents,
ISBN: 0080453449 ISBN-13(EAN): 9780080453446
: Elsevier Science
:
: 19855 .
  : .

: Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications.

Polyvinylpyrrolidone Excipients for Pharmaceuticals / Povidone, Crospovidone and Copovidone

: Bühler Volker
: Polyvinylpyrrolidone Excipients for Pharmaceuticals / Povidone, Crospovidone and Copovidone
ISBN: 3540234128 ISBN-13(EAN): 9783540234128
: Springer
:
: 23931 .
  : .

: The book describes the properties, analytical methods and the applications of different polyvinylpyrrolidone excipients (povidone, crospovidone, copovidone etc.) for use in pharmaceutical preparations. This group of excipients is one of the most important excipients used in modern technology to produce drugs. The book is intended for all persons working in the research, development and quality control of drugs. It gives a survey of all applications in solid, liquid and semisolid dosage forms including many drug formulation examples and more than 600 references to the literature.

Pharmaceuticals in the Environment

: K?mmerer
: Pharmaceuticals in the Environment
ISBN: 3540213422 ISBN-13(EAN): 9783540213420
: Springer
:
: 9400 .
  : .

: The study of pharmaceuticals in the environment is a relatively new area of research, which has only just taken off in recent years. Since the first edition was printed, many research articles on this subject have been published. It is exceedingly difficult for the individual, in particular those not acquainted with the field to establish  trends and developments. Even specialists will appreciate  this book, as it provides the reader with a well-founded over view.Following the resounding success of the first edition, this new edition has been brought up to date and greatly extended. It includes the status of research on soil, paying particular attention to field studies in  terrestrial and aquatic environments as well as new substance categories such as tetracylines and chinolones and  the latest results concerning contamination of the environment and risk reduction. In line with the newest developments worldwide there are now many more contributions from international authors. This volume also caters for the new requirements confronting  European and American researchers since publication of the first edition.

Polysaccharide Applications: Cosmetics and Pharmaceuticals

: El-Nokaly, Magda A.;Soini, Helena A.
: Polysaccharide Applications: Cosmetics and Pharmaceuticals
ISBN: 0841236410 ISBN-13(EAN): 9780841236417
: Oxford Academ
:
: 9088 .
  : .

: Polysaccharides are carbohydrates used in a number of industrial applications, such as as thickeners, gellants, emulsifiers, and delivery systems of many commercial products. Research in the area is limited, however, and this book fills this gap, providing an up-to-date look at polyccharide modifications, interactions with surfactants and micelles, stability, and characterization of polysaccharides.

Bioactive Carboxylic Compound Classes - Pharmaceuticals and Agrochemicals

: Lamberth
: Bioactive Carboxylic Compound Classes - Pharmaceuticals and Agrochemicals
ISBN: 3527339477 ISBN-13(EAN): 9783527339471
: Wiley
:
: 15015 .
  : .

: Following the successful and proven concept used in "Bioactive Heterocyclic Compound Classes" by the same editors, this book is the first to present approved pharmaceutical and agrochemical compounds classified by their carboxylic acid functionality in one handy volume.

Flow Injection Analysis of Pharmaceuticals

: Martinez-Calatayu
: Flow Injection Analysis of Pharmaceuticals
ISBN: 0748404457 ISBN-13(EAN): 9780748404452
: Taylor&Francis
:
: .
  : .

: A critical review of published papers, this volume presents theoretical and fundamental aspects of FIA-pharmaceutical analyses. Dividing the material into chapters based on measurement technique or type of detector, each chapter provides

Pharmaceuticals in the Environment

: K?mmerer
: Pharmaceuticals in the Environment
ISBN: 3540746633 ISBN-13(EAN): 9783540746638
: Springer
:
: 24976 .
  : .

: The study of pharmaceuticals in the environment is a relatively new area of research. This up-to-date and greatly extended third edition addresses the most important issues in the field for the near future.

HPLC Method Development for Pharmaceuticals,8

: Satinder Ahuja
: HPLC Method Development for Pharmaceuticals,8
ISBN: 0123705401 ISBN-13(EAN): 9780123705402
: Elsevier Science
:
: 26648 .
  : .

: High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.

Physicochemical Basis of Pharmaceuticals

: Moynihan, Humphrey; Crean, Abina
: Physicochemical Basis of Pharmaceuticals
ISBN: 0199232849 ISBN-13(EAN): 9780199232840
: Oxford Academ
:
: 5176 .
  : .

: The Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs.

Chromatography of Pharmaceuticals: Natural, Synthetic and Recombinant Products

: Chromatography of Pharmaceuticals: Natural, Synthetic and Recombinant Products
ISBN: 0841224986 ISBN-13(EAN): 9780841224988
: Oxford Academ
: 1379 .
  : .

: Describes the role of chromatography in the development of new drugs and features chapters on the analysis of natural and recombinant pharmaceutical products. The text also covers new techniques that combine liquid chromatography or gas chromatography with mass spectrometry.


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