Автор: Filippi Название: Neurodegeneration in Multiple Sclerosis ISBN: 8847003903 ISBN-13(EAN): 9788847003903 Издательство: Springer Цена: 19634 р. Наличие на складе: Поставка под заказ.
Описание: In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.
Автор: Filippi M., Arnold D.L., Comi G. Название: Magnetic Resonance Spectroscopy in Multiple Sclerosis ISBN: 8847001234 ISBN-13(EAN): 9788847001237 Издательство: Springer Цена: 9812 р. Наличие на складе: Поставка под заказ.
Описание: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".
Автор: Douglas S. Goodin Название: Multiple Sclerosis and Related Disorders,122 ISBN: 0444520015 ISBN-13(EAN): 9780444520012 Издательство: Elsevier Science Рейтинг: Цена: 24833 р. Наличие на складе: Поставка под заказ.
Описание: Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis.Over the pastfive years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.
Автор: Lawrence M. Samkoff,Andrew D. Goodman Название: Multiple Sclerosis and CNS Neuroimmunologic Disorders ISBN: 0470673885 ISBN-13(EAN): 9780470673881 Издательство: Wiley Рейтинг: Цена: 8800 р. Наличие на складе: Поставка под заказ.
Описание: Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides the scientific basis of multiple sclerosis including etio
Автор: Lavi Ehud, Constantinescu Cris S. Название: Experimental Models of Multiple Sclerosis ISBN: 0387255176 ISBN-13(EAN): 9780387255170 Издательство: Springer Рейтинг: Цена: 34649 р. Наличие на складе: Поставка под заказ.
Описание: Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.
Описание: In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.
Автор: Acc Название: Understanding Multiple Sclerosis Anatomical Chart ISBN: 1587799715 ISBN-13(EAN): 9781587799716 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 817 р. Наличие на складе: Поставка под заказ.
Описание: "This patient-friendly chart defines multiple sclerosis (MS) and details signs and symptoms and prevention and management techniques. The chart also shows the effect of MS on a normal nerve cell, comparing a normal myelin sheath to one damaged from the disease.
Автор: Acc Название: Understanding Multiple Sclerosis Anatomical Chart ISBN: 1587799723 ISBN-13(EAN): 9781587799723 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 1506 р. Наличие на складе: Поставка под заказ.
Описание: "This patient-friendly chart defines multiple sclerosis (MS) and details signs and symptoms and prevention and management techniques. The chart also shows the effect of MS on a normal nerve cell, comparing a normal myelin sheath to one damaged from the disease.
Автор: Stephen Waxman Название: Multiple Sclerosis As A Neuronal Disease, ISBN: 0127387617 ISBN-13(EAN): 9780127387611 Издательство: Elsevier Science Рейтинг: Цена: 23100 р. Наличие на складе: Поставка под заказ.
Описание: Examines the role of neurons in Multiple Sclerosis (MS) and the changes that occur in neurons as a result of MS. This book explains the basis for symptom production, remission and progress in MS. It brings together information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of MS.
Автор: Anthony Feinstein Название: The Clinical Neuropsychiatry of Multiple Sclerosis ISBN: 052185234X ISBN-13(EAN): 9780521852340 Издательство: Cambridge Academ Рейтинг: Цена: 13694 р. Наличие на складе: Поставка под заказ.
Описание: Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.
Автор: Perkin Название: An Illustrated Pocketbook Of Multiple Sclerosis ISBN: 1842141422 ISBN-13(EAN): 9781842141427 Издательство: Informa Рейтинг: Цена: 6848 р. Наличие на складе: Нет в наличии.
Описание: An authoritative introduction to Parkinson's disease and its related disorders and syndromes, this book provides a concise overview of the disease and its diagnosis and management. The author presents samples of clinical, investigative (CT, MRI, and PET) and pathological images with succinct descriptive text of the disorders featured. He describes the conditions related to Parkinson's disease, and the pictures provide pathological macroscopic and microscopic sections, various imaging studies, and details of movement disorders in general. The book will serve as a useful teaching tool that demonstrates the imaging and pathology of the disease.
Описание: A synthesis of current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of MRI, magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research and its applications to specific immunotherapies, and the use of immune markers for tracking the disease.
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