Автор: Leon Rosenberg Название: Human Genes and Genomes, ISBN: 0123852129 ISBN-13(EAN): 9780123852120 Издательство: Elsevier Science Рейтинг: Цена: 6350 р. 7937.00-20% Наличие на складе: Есть (1 шт.) Описание: In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines.
Описание: As life expectancy has increased, so has the incidence of neurodegenerative diseases, particularly those associated with aging. Contributing to increased life
expectancy is increased survival following brain injury, stroke, and procedures such as heart surgery, but these events can impair neurological function. The wide range of contributions
to this volume, from a detailed paper on the use of gene therapy in combination with hypothermia for the treatment of cerebral ischemia to a comprehensive poster d
scribing the role of anesthetic agents in neurotoxicity during development and senescence, illustrate the scientific scope presented.
Contributions from clinical and basic
science researchers from many disciplines address various approaches to providing neuroprotection. The clinical focus is on the complexity of neuroprotection, the need for
understanding the time-course effects of hypoxia/ischemia, and the need for combinational and time-course applications of multiple therapies. New technologies are introduced for
describing both the insult and the treatment necessary for neuroprotection, including gene expression assays (genomics) and gene therapy.
Several chapters are devoted to
the examination of the predictive value of models for outcome measures in clinical ischemic stroke neuroprotective trials. The need to move from in vitro models to more predictive in
vivo approaches with the use of pharmacokinetics is addressed. Other chapters emphasize the role of endogenous agents such as nitric oxide, melatonin, L-carnitine, and estrogens in
acute and chronic neural injury and therapy.
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Описание: X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules at atomic resolution. These structures are central to understanding the detailed mechanisms of biological processes, and to discovering novel therapeutics using a structure-based approach. As yet, structures are known for only a small fraction of the proteins encoded by human and pathogenic genomes. To counter the myriad modern threats of disease, there is an urgent need to determine the structures of the thousands of proteins whose structure and function remain unknown. This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis, and show how modern high-throughput methods are contributing to a deeper understanding of medical problems.
Описание: This is a timely volume in view of the considerable interest currently shown in the preservation of our cultural heritage and the extensive and growing literature on the subject. Unfortunately, the latter is to be found in a wide variety of published sources, some aimed at a very specific readership. The present volume draws together a spectrum of biodeterioration work from across the world to provide an overview of the materials examined and the methodologies employed to elucidate the nature of the problems, as well as an extensive and current bibliographical resource on lichen biodeterioration.Generally, we do not think of rock surfaces as particularly conducive to the growth and development of living things. Occasionally, we may encounter grasses or forbs or even more rarely a small shrub or stunted tree growing from a crack in a large boulder or rock wall; but for most people, rock is perceived as dry, sterile, impenetrable, and generally uninviting. However, to the experienced eye rock surfaces are often teeming with life вЂ“ lichens, bryophytes, a host of small invertebrate animals, as well as a vast array of microscopic organisms including bacteria, cyanobacteria, algae and non-lichenized fungi. The longevity and structural stability of most rocks superficially suggest that rock surface inhabitants are benign; however, slowly and steadily all rock dwelling organisms contribute to the relentless decomposition of rock surfaces вЂ“ augmented by the natural physical forces associated with changing seasons, weather patterns, and in some localized settings the caustic effects of air pollution. Rock dwelling communities vary in complexity and composition depending on the specific structural and chemical features of the rock. Even human manipulated or manufactured stone supports to some degree a living community вЂ“ and herein are found the real issues and concerns related to biodeterioration of rock substrata. In a natural setting biodecomposition of rock is accepted as normal and even desirable вЂ“ integral to the process of soil development; however, in the human environment biodeterioration of monuments, buildings, artwork, statues and gravestones is counted as a serious problem. Even in natural settings, culturally significant prehistoric and historic rock art is subject to the same processes of biodeterioration.In this volume the editors have compiled current papers from leading experts dealing with various issues related to biodeterioration of rock substrata. Topics range from biodeterioration effects on prehistoric rock art as well as culturally significant, historic rock structures. This is the first treatment of the subject of biodeterioration that includes a careful consideration of the role of related disciplines including geology, archaeology, crystallography, cultural conservation and resource management. This combination of disciplines makes this book valuable not only as a solid scientific treatise but equally important as a serious resource for evaluating both impact processes and preservation options related to biodeterioration of culturally significant rock substrata.
Описание: DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This book covers calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays.
Описание: Intended for scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. This title covers the methods that have general applicability to small molecules as well as oligomers and proteins. It includes examples that provide general principles involved in sequence recognition.
Описание: Describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders,and more. This volume includes features such as: drug design and therapeutic applications; Nucleic acid-protein interactions; and more.
Автор: Alex A. Adjei Название: Novel Anticancer Agents, ISBN: 0120885611 ISBN-13(EAN): 9780120885619 Издательство: Elsevier Science Рейтинг: Цена: 17243 р. Наличие на складе: Поставка под заказ.
Описание: Provides an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. This book addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field and discusses regulatory issues surrounding drug development.
Автор: Ronald J. Bradley Название: Neuroprotective Agents and Cerebral Ischaemia,40 ISBN: 0123668409 ISBN-13(EAN): 9780123668400 Издательство: Elsevier Science Рейтинг: Цена: 17243 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Presents a review of the research and developing therapies for stroke. This book describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode. It also presents the factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents.
Автор: Robert A. Wilson Название: Genes and the Agents of Life ISBN: 0521836468 ISBN-13(EAN): 9780521836463 Издательство: Cambridge Academ Рейтинг: Цена: 7477 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Genes and the Agents of Life undertakes to rethink the place of the individual in the biological sciences, drawing parallels with the cognitive and social sciences. Genes, organisms, and species are all agents of life but how are each of these conceptualized within genetics, developmental biology, evolutionary biology, and systematics? The book includes highly accessible discussions of genetic encoding, species and natural kinds, and pluralism above the levels of selection, drawing on work from across the biological sciences. The book is a companion to the author’s Boundaries of the Mind, also available from Cambridge, where the focus is the cognitive sciences. The book will appeal to a broad range of professionals and students in philosophy, biology, and the history of science.
Автор: Richard J. Reece Название: Analysis of Genes and Genomes ISBN: 0470843802 ISBN-13(EAN): 9780470843802 Издательство: Wiley Рейтинг: Цена: 5400 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a course that describes the tools and techniques of genetic engineering. This book takes an example-driven approach to underline the fundamentals of; creating mutations in DNA, cloning in bacteria, yeast, planand animals - including the identification of disease genes.
Автор: Weidmann Название: A Guide to Working with BSL-3/4 Agents ISBN: 352733467X ISBN-13(EAN): 9783527334674 Издательство: Wiley Рейтинг: Цена: 9818 р. Наличие на складе: Поставка под заказ.
Описание: This is a training manual for staff working in BSL3/4 laboratories. It is based on a course developed in the frame of COST Action B28 and subsequently funded by DG Home Affairs. It covers bio-containment, hazard criteria, the categorization of microbe
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