Автор: Karp Judith Название: Acute Myelogenous Leukemia ISBN: 1588296210 ISBN-13(EAN): 9781588296214 Издательство: Springer Рейтинг: Цена: 26021 р. Наличие на складе: Поставка под заказ.
Описание: Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas, and both basic and clinical scientists will benefit from this translational text.
Автор: Pui Название: Childhood Leukemias ISBN: 0521196612 ISBN-13(EAN): 9780521196611 Издательство: Cambridge Academ Рейтинг: Цена: 23353 р. Наличие на складе: Поставка под заказ.
Описание: New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.
Описание: Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. Thus, several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia. Given our intention that the book be useful to clinicians, we pay particular attention to these advances, to management of acute leukemia in general, and to development of new therapies.
Автор: Kantarjian Название: Leukemias ISBN: 1405182350 ISBN-13(EAN): 9781405182355 Издательство: Wiley Рейтинг: Цена: 14409 р. Наличие на складе: Поставка под заказ.
Описание: Edited by experts from one of the world?€™s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatme
Автор: Reaman Название: Childhood leukemia ISBN: 3642137806 ISBN-13(EAN): 9783642137808 Издательство: Springer Рейтинг: Цена: 17764 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a comprehensive and up-to-date compendium on all aspects of childhood leukemia. After introductory chapters on the epidemiology and biology of pediatric leukemia, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. Promising targeted agents are discussed, and strategies for the development of new agents are appraised. The late effects of leukemia and its therapy are then considered in depth, with due attention to management of the psychosocial impact of the disease. Finally, global strategies to improve leukemia care and outcome are reviewed, and future directions discussed. The authors are internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric leukemia and will prove invaluable to specialists, generalists, and trainees alike.
Описание: This issue concentrates on the current evidence and the collected experience of pediatric oncologists who care for cancer patients. The individual articles will provide the general pediatrician with a comprehensive primer on diagnosing and managing various types of cancers in the child with cancer. A cancer diagnosis is no longer a death sentence, so management and monitoring is very important and covered in every article.
Описание: Focuses on Chronic Lymphocytic Leukemia. In this book, topics include: What Have Recent Genomic Advances Taught us About CLL?, Biology of CLL in Different Microenvironments, What is the Significance of Stereotyped BCRs in CLL?, and Evolving Role of Stem Cell Transplantation in CLL.
Описание: Assembles top experts to write reviews on the management of chronic myelogenous leukemia. This title includes articles: Selection of Therapy: Rational Decisions Based on Molecular Events; Is There a Potential Cure for CML in Current Therapies? Hurdles Toward a Cure for CML: The CML Stem Cell; and, Management of Ph+ ALL and CML Blast Crisis.
Описание: Includes topics such as: CLL - A Historical Perspective; Incidence & Epidemiology; Biology, Molecular Biology & Cytogenetics of CLL; What does the status of smatic hypermutations in IGVH genes tell us about the origin of CLL?; What does the status of ZAP-70 tell us about the biology of CLL? And, approach to initial therapy - When to start therapy?
Описание: This valuable reference provides a timely summary of current therapies for chronic myelogenous leukemia (CML), discussing both basic pathophysiology and new experimental strategies. Combining the insights of over 30 prominent researchers in the field, Medical Management of Chronic Myelogenous Leukemia
compares interferon therapy with conventional chemotherapy
covers chronic, accelerated, and Philadelphia-negative phases
details standard therapy with IFN- regimens and allogenic stem cell transplantation
describes the utility and limitations of CML animal models
profiles clinical trials testing IFN in combination with other agents
assesses improvements in survival times among CML patients
reviews the effectiveness of Southern blot monitoring
traces the development of oligonucleotides as potential therapeutic agents
outlines therapy with monoclonal antibodies, targeted NK cells, and immune T cells
and more! Containing over 1500 references, tables, drawings, and photographs, Medical Management of Chronic Myelogenous Leukemia is suitable for clinical oncologists, hematologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, and residents, fellows, and medical school students in these disciplines.
Автор: Polliack Название: Hairy Cell Leukemia ISBN: 9058230090 ISBN-13(EAN): 9789058230096 Издательство: Informa Рейтинг: Цена: 6902 р. Наличие на складе: Нет в наличии.
Описание: This volume addresses all aspects of hairy cell leukemia, embracing the history of the disease and all aspects of modern therapy, including morphology, electron-microscopy, histopathology, biological and immunological aspects and diagnoses.
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