Описание: The book`s many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis.
Описание: Of the 8 million individuals living with cancer in the United States, up to 800,000 patients have a form of inherited cancer. Inherited cancer syndromes account for 5-10% of all cancers, as evidenced by recent advances in the understanding of such syndromes as Familial Polyposis Syndromes (FAP), Hereditary Nonpolyposis Colon Cancer (HPNCC), and the BRCA1 and 2 breast cancer susceptibility genes. Inherited Cancer Syndromes: Current Clinical Management provides the clinician with a valuable tool for all aspects of patient care in inherited syndromes. Comprehensive, timely chapters present the fundamental principles of genetic counseling and testing, ethical issues, medical-legal issues, and clinical management principles. Chapters on inherited breast cancer, colon cancer, urologic malignancies, gynecologic malignancies, and MEN syndromes provide state-of-the-art information on hereditary risk identification, assessment and management, the role of the genetic counselor, providing optimal patient care, and the important research on the horizon - all written by an expert group of surgical and medical oncologists. Inherited Cancer Syndromes: Current Clinical Management is an important and timely book for surgical oncologists, medical oncologists, radiation oncologists, general surgeons, colorectal surgeons, trainees in surgery and oncology, and genetic counselors.
Описание: For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease.
Описание: Strategies of treatment involving therapeutic proteins, irnrnune immune cells, or cel- lular protein targets are those of greatest potential for further reducing mortality from melanoma. Therapeutic proteins or cells may inhibit melanoma cell growth either by augmentation of immune cell function or by inhibition of angiogenesis. Cytokines and melanoma antigens may be used either in vivo as a vaccine to stimulate irnrnune immune cell cell function or ex vivo to stimulate or proliferate cells for infusion. Alternatively, alteration in melanoma cell growth can occur through inhibition of protein signal transduction pathways within melanoma cells or in the endothelial cells constituting the necessary angiogenic support for tumor growth. The great promise of these therapies and their cellular targets constitutes the basis for Melanoma: Biologically Targeted Therapeutics. THE CLINlCAL PROBLEM More than four million people will be diagnosed with melanoma in the first decade of the 21st century. Half of those who will die will be individuals who would otherwise have had a life expectancy of another 25 years or more. These individuals will die of systemic systernic metastases, which are present at the time of primary surgery. Despite use of sunscreens, incidence continues to increase in developed countries worldwide. To reduce mortality, there must continue to be a focus on prevention and earlier detection through public education. Early interventions are always preferable to treatment of disseminated metastatic disease.
Автор: Gewirtz Alan M. Название: Nucleic Acid Therapeutics in Cancer ISBN: 1588292584 ISBN-13(EAN): 9781588292582 Издательство: Springer Рейтинг: Цена: 23100 р. Наличие на складе: Поставка под заказ.
Описание: A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Описание: The urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains. This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targeted therapeutics. It offers coverage of various aspects of a selected domain of tumor immunology.
Описание: Combines two aspects, namely cancer research and the drug design and delivery from an integrated perspective of cancer treatment. This book describes various aspects of anticancer strategies and drug delivery approaches from different perspectives, including detailed discussion of several clinical trial cases.
Автор: Shah Название: Stem Cell Therapeutics for Cancer ISBN: 1118282426 ISBN-13(EAN): 9781118282427 Издательство: Wiley Рейтинг: Цена: 17325 р. Наличие на складе: Поставка под заказ.
Описание: A single-source reference on the hot topic of stem cell therapeutics for cancer This work offers a thorough, cohesive look at the state of the art of stem cell therapeutics for cancer, with an emphasis on the unique application of mesenchymal stem cells
Автор: Cell Press Название: Cell Press Reviews: Cancer Therapeutics, ISBN: 012420192X ISBN-13(EAN): 9780124201927 Издательство: Elsevier Science Рейтинг: Цена: 3228 р. Наличие на складе: Поставка под заказ.
Описание: Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including:. . Genetic approaches for personal oncology. Targeting epigenetic dysregulation and protein interaction networks. Vaccines and antibodies in cancer immunotherapy. Tumor heterogeneity and chemotherapy resistance. Tumor associated macrophages in anticancer treatment. Contributions come from leading voices in the field, including:- Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School- Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics- Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences. Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviewsseries, which features reviews published in Cell Press primary research and Trends reviews journals.
Автор: K Park Название: Biomaterials for Cancer Therapeutics, ISBN: 0857096648 ISBN-13(EAN): 9780857096647 Издательство: Elsevier Science Рейтинг: Цена: 23678 р. Наличие на складе: Поставка под заказ.
Описание: Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.
Описание: Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long–term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.
Описание: Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.
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