Описание: Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume provides an overview of the mechanisms and biological consequences of the genome rearrangements resulting from horizontal gene transfer, in both prokaryotes and eukaryotes, as well as overviews of the key mobile genetic elements involved. Subsequent chapters focus on paradigms for the evolution of important bacterial pathogens, including Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The influence of socioeconomic parameters in the dissemination of transferable elements, such as antibiotic resistant genes in bacteria, is also discussed.
Описание: Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors. An accompanying volume, Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics.
Автор: Michael Syvanen Название: Horizontal Gene Transfer, ISBN: 0126801266 ISBN-13(EAN): 9780126801262 Издательство: Elsevier Science Рейтинг: Цена: 13629 р. Наличие на складе: Поставка под заказ.
Описание: This work discusses the phenomenon of horizontal gene transfer, the transfer of genetic material from one organism to another. Since this is the main mechanism for the spread of bacterial antibiotic resistance, the mechanisms and processes have broad scientific interest and clinical relevance. Horizontal gene transfer is the transfer of genetic material from one organism to another, thought to be a major mechanism of genome evolution. The completion of the entire human genome sequence has provided valuable evidence for this phenomenon, expanding our knowledge of evolutionary biology and accelerating the development of GM foods. This second edition of "Horizontal Gene Transfer" has been organized to provide a concise and up-to-date coverage of the most important discoveries in this fascinating field. Written by prominent gene transfer and genome analytical scientists, the book details experimental evidence for the phenonemon of horizontal gene transfer and discusses further evidence provided by the recent completion of genomic sequences from Archea, Bacteria and Eucarya members. It should be valuable reading for microbiologists, geneticists, biochemists, evolutionary biologists, infectious disease specialists, paleontologists, ecologists, and researchers working on plant/animal systematics and agriculture with an interest in gene transfer.
Описание: The thalamus is the last frontier in brain research. It is the least studied region, most likely because it is very complex. The thalamus and basal ganglia are better characterized in nonhuman primates, and this information can be extrapolated to the human thalamus. This atlas can be used for identification of the thalamic nuclei in neuroanatomical, neurochemical, and neurophysiological studies and for guiding probes into the target nuclei during stereotactic surgery in nonhuman primates. The atlas consists of two parts: (1) a book with approximately 30 representative sagittal histological plates corresponding to nuclear outlines and identification; and (2) an interactive CD-ROM containing approximately 85 color-coded maps. The CD-ROM serves to enhance the images in the book by showing three-dimensional interrelationships between the different planes.
Описание: This book provides an extensive, worldwide overview of wastewater treatment via constructed wetlands with horizontal sub-surface flow (HF CWs). Special attention is paid to assessing the use of this treatment technology in individual countries.
Описание: * Covers a new approach to gene therapy with a greatly improved safety profile * Complete coverage of the topic including molecular basis, production and biomedical applications * Has a wide audience including everyone who is directly or indirectly involved in the development of gene therapies .
Описание: The production of proteins in mammalian cells is an important tool in numerous scientific and commercial areas. For example, proteins for human therapy,
vaccination or diagnostic applications are typically produced in mammalian cells. Gene cloning, protein engineering, biochemical and biophysical characterization of proteins also require
the use of gene expression in mammalian cells.
Other applications in widespread use involve screening of libraries of chemical compounds in drug discovery, and the
development of cell-based biosensors. This book presents a state-of-the-art comprehensive coverage of the technical aspects of gene expression in mammalian cells, written by
experienced scientists working at the forefront of the field.
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