Автор: Hancock John Название: Cell Signalling ISBN: 019965848X ISBN-13(EAN): 9780199658480 Издательство: Oxford Academ Цена: 4162 р. Наличие на складе: Есть у поставщикаПоставка под заказ. Описание: Cell Signalling presents a carefully structured and accessible introduction to this intricate and rapidly growing field. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling.
Автор: Hancock, John Название: Cell Signalling ISBN: 0199264678 ISBN-13(EAN): 9780199264674 Издательство: Oxford Academ Цена: 2913 р. Наличие на складе: Поставка под заказ. Описание: Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems. Starting with an overview of cell signalling, which highlights its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create the signalling pathways, which are so crucial to the survival of all living organisms.
Автор: Hancock John Название: Cell Signalling ISBN: 019965848X ISBN-13(EAN): 9780199658480 Издательство: Oxford Academ Рейтинг: Цена: 4162 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cell Signalling presents a carefully structured and accessible introduction to this intricate and rapidly growing field. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling.
Описание: Presents a treatment of G-Protein Signaling, Part A, and covers general methods of analysis of RGS protein analysis, including expression and post-translational modification, assays of GAP activity and allosteric control, electrophysiological methods and RGS-insensitive Ga subunits, and mouse models of RGS protein action.
Автор: Howie Sarah, Fisher Carolyn Elaine Название: Shh and Gli Signalling in Development ISBN: 0387399569 ISBN-13(EAN): 9780387399560 Издательство: Springer Рейтинг: Цена: 18700 р. Наличие на складе: Поставка под заказ.
Описание: This book reviews what is known about the Sonic Hedgehog pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and man. The book can be read in its entirety to provide readers with a comprehensive review of the importance of this signalling pathway for normal development and insights into on-going research in this field. Such an approach may be useful for under graduates or post-graduate students with an interest in development, cell signalling cascades or those specifically researching some aspect of Shh.
Описание: Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Описание: This work offers descriptions of experimental methods in research on the cytoskeleton and its relationships to signalling and cell regulation. The focus is directed particularly towards methods which take advantage of advances in molecular biology, microscopy and immunological assays.
Описание: This study contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its homologues.
Автор: Helmreich, Ernst Название: The Biochemistry of Cell Signalling ISBN: 0198508204 ISBN-13(EAN): 9780198508205 Издательство: Oxford Academ Рейтинг: Цена: 8847 р. Наличие на складе: Поставка под заказ.
Описание: 'The Biochemistry of Cell Signalling' is a comprehensive yet concise study of the principles of cell signalling, concentrating on the structural and mechanistic aspects.
Описание: This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? - Are there 'master switches' present in every cell type? - How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? - What is the influence of the extracellular matrix on cell movement and internal signalling pathways? - How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.
Автор: Henderson Название: Molecular Chaperones and Cell Signalling ISBN: 0521177472 ISBN-13(EAN): 9780521177474 Издательство: Cambridge Academ Рейтинг: Цена: 2913 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
Описание: An introduction to the field of signal transduction. It aims to break signaling down into common elements and activities - the `nuts and bolts` of cellular information exchange. It addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding.
Описание: Presents an introduction to the field of cell signaling. This book addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding. It is suitable for students of biochemistry, cell and molecular biology, physiology, biomedicine and oncology.
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