Описание: The Second Edition of Giant Molecules presents an introductory textbook on large molecules that exhibit specific physical and biological properties related to their size, orientation, and environment, making this subject accessible to students from high school to universities.
Автор: Decker, Michael Название: Design of Hybrid Molecules for Drug Development ISBN: 0081010117 ISBN-13(EAN): 9780081010112 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.
Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.
With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
Compares the advantages and disadvantages of these compounds
Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Автор: Turro Nicholas J. Название: Modern Molecular Photochemistry of Organic Molecules ISBN: 1891389254 ISBN-13(EAN): 9781891389252 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A complete revision of Turro`s classic text, Modern Molecular Photochemistry, which has been the standard of the field for three decades. It presents a clear introduction to organic chemistry and goes on to cover the mechanisms of organic photoreactions and the photochemistry of the basic functional groups of organic chemistry.
Автор: Robert V. Stick Название: Carbohydrates: The Essential Molecules of Life, ISBN: 0240521188 ISBN-13(EAN): 9780240521183 Издательство: Elsevier Science Рейтинг: Цена: 12294.00 р. Наличие на складе: Поставка под заказ.
Описание: Carbohydrates are the building blocks of life and enable biological processes to take place. This book describes the basic chemistry and biology of carbohydrates. It reviews the concepts, synthesis, reactions and biology of carbohydrates.
Описание: This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of 'steroid-like' natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
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