Protein Kinase C in Cancer Signaling and Therapy, Kazanietz
Автор: Marcelo G. Kazanietz Название: Protein Kinase C in Cancer Signaling and Therapy ISBN: 1617796913 ISBN-13(EAN): 9781617796913 Издательство: Springer Рейтинг: Цена: 34535 р. Наличие на складе: Поставка под заказ.
Описание: Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980`s with its identification as an effector of phorbol esters, natural products with tumor promoting activity.
Описание: In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.
Автор: Haley John D. Название: EGFR Signaling Networks in Cancer Therapy ISBN: 1588299481 ISBN-13(EAN): 9781588299482 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: This volume in the series specifically addresses the crosstalk of EGF receptor complexes with other signaling systems, from a scientific and clinical perspectiv and will give an interesting view and insight into the effective use of targeted inhibitor combinations in cancer treatment.
Автор: John D. Haley; William John Gullick Название: EGFR Signaling Networks in Cancer Therapy ISBN: 1617378534 ISBN-13(EAN): 9781617378539 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues. This volume probes and explores this fascinating system with compelling information.
Автор: Terrian David M. Название: Cancer Cell Signaling / Methods and Protocols ISBN: 1588290751 ISBN-13(EAN): 9781588290755 Издательство: Springer Рейтинг: Цена: 16746 р. Наличие на складе: Поставка под заказ.
Описание: A collection of readily reproducible experimental methods for studying the subversion of normal cell signaling that leads to cancer. Presented in step-by-step detail to ensure successful results, the methods include proven techniques for the investigation of apoptosis and cell death, complementary protocols for manipulating and/or monitoring oncogenic signals in cancer cells, and techniques for studying protein-protein interactions. A detailed protocol for capturing pure samples of malignant cells from frozen tissue specimens and two alternative techniques for analyzing their genomic DNA is also described.
Описание: Suitable for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. This book covers various findings relevant to cellular and molecular functions of polyamines. It also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting polyamines and polyamine metabolism.
Описание: This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways.
Автор: Glick Название: Signaling Pathways in Squamous Cancer ISBN: 1441972021 ISBN-13(EAN): 9781441972026 Издательство: Springer Рейтинг: Цена: 28760 р. Наличие на складе: Поставка под заказ.
Описание: Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
Автор: Johnson Название: Cell Death Signaling in Cancer Biology and Treatment ISBN: 1461458463 ISBN-13(EAN): 9781461458463 Издательство: Springer Рейтинг: Цена: 19634 р. Наличие на складе: Поставка под заказ.
Описание: Discussing both preclinical and clinical approaches to targeted attacks on tumor cells, this is a key contribution to the fight against cancer, sharing cutting-edge research on the molecular and biological processes regulating cell death in malignant tumors.
Автор: Reichrath Название: Notch Signaling in Embryology and Cancer ISBN: 1461408989 ISBN-13(EAN): 9781461408987 Издательство: Springer Рейтинг: Цена: 20789 р. Наличие на складе: Поставка под заказ.
Описание: The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.
Описание: Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Описание: Natural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids.
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