Targeted therapies in breast cancer, Burstein, Harold

Автор: Manfred Dietel
Название: Targeted Therapies in Cancer
ISBN: 3642432433 ISBN-13(EAN): 9783642432439
Издательство: Springer
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Цена: 23757.00 р.
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Описание: From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Автор: Francesco Colotta; Alberto Mantovani
Название: Targeted Therapies in Cancer:
ISBN: 1441925376 ISBN-13(EAN): 9781441925374
Издательство: Springer
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Цена: 20896.00 р.
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Описание: This crucial text offers readers an overview of diverse approaches to targeted cancer therapies, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.

Автор: Daniel Gioeli
Название: Targeted Therapies
ISBN: 1617797448 ISBN-13(EAN): 9781617797446
Издательство: Springer
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Цена: 27951.00 р.
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Описание: Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.

Автор: Amanda Tivnan
Название: Resistance to Targeted Therapies Against Adult Brain Cancers
ISBN: 331946504X ISBN-13(EAN): 9783319465043
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.