Описание: Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze this premise. Therefore, until a clearer picture of the disease emerges it is best to treat each of the MDS syndromes as a separate entity. Having no classification is better than a misleading one. Cancer research has been notable for its periodic cycles of promise and hope, followed by defeat and disappointments. It is not that there is no solution, but that the problem has not been identified precisely. This book is our attempt to define the most crucial questions related to MDS that need to be addressed immediately through logic, analysis and rigorous experimentation. If the emerging problems appear daunting, then instead of being overwhelmed by them, we should follow the advice of the great 20th century thinker Antonio Gramsci, `pessimism of the intellect must be faced with the optimism of will'.
Автор: Bennett John Название: Myelodysplastic Syndromes ISBN: 0824707826 ISBN-13(EAN): 9780824707828 Издательство: Informa Рейтинг: Цена: 20789 р. Наличие на складе: Нет в наличии.
Описание: Provides an overview of the research detailing the etiology, epidemiology, treatment, and detection of myelodysplastic syndromes (MDS). This book identifies effective therapeutic regimens, adverse environmental and genetic factors, and more. It is for oncologists, hematologists, immunologists, pathologists, molecular biologists, and others.
Автор: Peter L. Greenberg Название: Myelodysplastic Syndromes ISBN: 0521496683 ISBN-13(EAN): 9780521496681 Издательство: Cambridge Academ Рейтинг: Цена: 28382 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Myelodysplastic Syndromes was first published in 2006, and continues to stand out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. It remains a major reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes. Authored by international experts, the book provides an assessment of the subject's status and a variety of advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.
Автор: Jameson J. Larry Название: Hormone Resistance Syndromes ISBN: 0896036529 ISBN-13(EAN): 9780896036529 Издательство: Springer Рейтинг: Цена: 29700 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone, glucocorticoid resistance, hereditary resistance to vitamin D, and estrogen resistance. Throughout, the book's distinguished contributors not only summarize the clinical features of these and related disorders, but also illuminate their molecular bases. Hormone Resistance Syndromes provides an authoritative summary and standard reference for all those clinicians and researchers actively studying these mutations today and affords a unique opportunity to understand hormone action in normal physiology.
Автор: Deeg Название: Myelodysplastic Syndromes ISBN: 3540261885 ISBN-13(EAN): 9783540261889 Издательство: Springer Цена: 14397 р. Наличие на складе: Нет в наличии.
Описание: This book summarizes our current knowledge of MDS, from very basic aspects to the clinical management. It provides guidance to the diagnosis, an
understanding of disease mechanisms, and a discussion of treatment strategies.
Автор: Greenberg Название: Myelodysplastic Syndromes ISBN: 052118228X ISBN-13(EAN): 9780521182287 Издательство: Cambridge Academ Рейтинг: Цена: 6868 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Myelodysplastic Syndromes was first published in 2006, and continues to stand out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. It remains a major reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes. Authored by international experts, the book provides an assessment of the subject's status and a variety of advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.
Автор: Lee Название: Hematologic Abnormalities and Acute Lung Syndromes ISBN: 3319419102 ISBN-13(EAN): 9783319419107 Издательство: Springer Рейтинг: Цена: 16334 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.
Автор: Weatherall Название: Thalassaemia Syndromes ISBN: 0865426643 ISBN-13(EAN): 9780865426641 Издательство: Wiley Цена: 9529 р. Наличие на складе: Поставка под заказ.
Описание: The thalassaemias, the commonest single gene diseases, are a heterogeneous family of inherited disorders of haemoglobin. In many countries they constitute
a major public health problem and are a severe drain on medical resources. Thalassaemias were among the first diseases to be studied at the molecular level and much is now known
about the genetic basis for their remarkable clinical variability.
Hence their study has provided a model for understanding the clinical diversity of monogenic diseases in
general. The new fourth edition of this highly-acclaimed book has been completely rewritten and re-organized to provide a detailed review of the entire thalassaemia field, including the
structure and genetic control of normal haemoglobin, the molecular pathology of the different forms of thalassaemia, a description of their clinical features and their interactions with
different haemoglobin variants, and a full description of their population control, diagnosis, and management. The new Fourth Edition contains Colour illustrations of patients, blood
films and tissue sections Completely new sections on the syndromes of a thalassaemia and mental retardation, molecular pathology, population genetics, the ethical issues raised by
programmes for population control, and a new section on experimental forms of treatment which may be of relevance in the future A greatly expanded section on the management
of thalassaemia Extensive tables of the interactions of the different thalassaemia alleles An appendix providing the addresses of thalassaemia societies in countries throughout the
world Thalassaemia Syndromes is a unique reference that is devoted entirely to the different forms of thalassaemia.
It provides an extensive bibliography of reference to all the
original descriptions of the different thalassaemia interactions and will provide an indispensable reference source for clinicians and laboratory technical staff investigating these
disorders.
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