Автор: Butzphal, Gerlinde; Maier-Fairclough, Ja Название: IELTS Target 5.0 CB and WB audio DVD New ed ISBN: 1908614935 ISBN-13(EAN): 9781908614933 Издательство: Garnet Education Цена: 2650 р. Наличие на складе: Есть Описание: A preparation course for the IELTS Academic examination.
Автор: Lindner-Olsson E., Chatzissavidou N., LГјllau E. Название: Animal Cell Technology: From Target to Market ISBN: 1402002645 ISBN-13(EAN): 9781402002649 Издательство: Springer Рейтинг: Цена: 26179 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is the lasting product, a resource of up-to-date information in the scientific literature for the field of animal cell technology, as it was presented during a pleasant and stimulating meeting in TylГ¶sand, Sweden, in June 2001. The title of the meeting, From Target to Market, indicates the usefulness of Animal Cell Technology during all steps in the pharmaceutical development process. Following the biotech products reaching the market, it shows an upward trend in the contribution of biotech products to total New Molecular Entity output in the nineties, which continued until 1996 when biotech represented 25% of the annual output. Since then the proportion has been decreasing. A perceived hurdle from a market perspective is that a protein per definition is biodegradable and thus requires intravenous, or for some drugs subcutaneous administration. New promising administration technologies such as pulmonary delivery were highlighted at this meeting. The emphasis on project selection prior to entry in the development phase has triggered a portfolio management using more extensive preclinical data before a development decision is taken. Animal cells have become a very important tool in the drug discovery process. The next generation of products will evolve from applications such as gene therapy, novel vaccines, cell therapy, and gene regulation. Animal cell technology has a major role to play in the post-sequence era.
Автор: Stanley Название: Pesticide Toxicity to Non-target Organisms ISBN: 9401777500 ISBN-13(EAN): 9789401777506 Издательство: Springer Рейтинг: Цена: 20097 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The pesticide should cause effect on the target pests and be selective enough to spare the non-target beneficial. The book deals with the pesticide toxicity to predators, parasitoids and microbes which are used for pest management in the agroecosystem. The other beneficials exposed to pesticides are pollinators, earthworms, silkworm and fishes. The book contains information on the modes of pesticide exposure and toxicity to the organisms, sub-lethal effects of insecticides and method of toxicity assessment, risk assessment of pesticidal application in the field. The purpose of the work is to compile and present the different procedures to assess pesticide poising in organisms related to the agroecosystem along with discussions on risk assessment procedures with clear comparison of toxicity of pesticides to target pests and non target beneficial organisms.
Описание: Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells.
Описание: This textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.
Описание: Meristematic cells in plants (as with stem cells in animals) become the many different types of cells found in a mature plant. This is achieved by a selective
response to chemical signals both from neighbouring cells and distant tissues. It is these responses that shape the plant, its time of flowering, the sex of its flowers, its length of survival
or progress to senescence and death.
How do plants achieve this? This up-to-date treatise addresses this question using well-chosen examples to illustrate the concept of
target cells. The authors discuss how each cell has the ability to discriminate between different chemical signals, determining which it will respond to and which it will ignore. The
regulation of gene expression through signal perception and signal transduction is at the core of this selectivity and the Target Cell concept.
This volume will serve as a
valuable reference for all researchers working in the field of plant developm
Описание: Aims to discuss the progress in our understanding of the molecular mechanisms of most human diseases and technical advances in target identification and validation. This book covers topics such as cancers, autoimmune diseases, cell signaling, gene profiling technologies, tumor immunology, tumor editing, immune tolerance and transgenic animals.
Описание: Start-to-finish guidance toward building and implementing a robust DC plan Successful Defined Contribution Investment Design offers a comprehensive guidebook for fiduciaries tasked with structuring and implementing a 401(k) or other defined contribution (DC) pension plan.
Описание: The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
Автор: Marco F. Schmidt Название: Drug Target miRNA ISBN: 1493965611 ISBN-13(EAN): 9781493965618 Издательство: Springer Рейтинг: Цена: 13089 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.
Описание: Founded in 1962 by Minnesota based department store Dayton`s, Target has grown to become America`s second most profitable retailer behind Wal Mart. This book examines the methods and the success of the company from its shrewd merchandising strategy to its clever marketing campaigns, ingenious branding effort, and extensive philanthropy.
Название: Determination Of Target Xenobiotics ISBN: 149878013X ISBN-13(EAN): 9781498780131 Издательство: Taylor&Francis Рейтинг: Цена: 25080 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Xenobiotics are chemical compounds foreign to a given biological system. In animals and humans, xenobiotics include drugs, drug metabolites, and environmental pollutants. In the environment, xenobiotics include synthetic pesticides, herbicides, and industrial pollutants. Many techniques are used in xenobiotics residue analysis; the method selected depends on the complexity of the sample, the nature of the matrix/analytes, and the analytical techniques available. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.