Protein Engineering for Therapeutics, Part B,503, K. Dane Professor Wittrup
Автор: Lo Benny K. C. Название: Antibody Engineering / Methods and Protocols ISBN: 1588290921 ISBN-13(EAN): 9781588290922 Издательство: Springer Рейтинг: Цена: 20211 р. Наличие на складе: Поставка под заказ.
Описание: A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.
Автор: MГјller Kristian, Arndt Katja Название: Protein Engineering Protocols ISBN: 1588290727 ISBN-13(EAN): 9781588290724 Издательство: Springer Рейтинг: Цена: 21366 р. Наличие на складе: Поставка под заказ.
Описание: Protein engineering is a fascinating mixture of molecular biology, protein structure analysis, computation, and biochemistry, with the goal of developing useful or valuable proteins. Divided into two sections, Protein Engineering Protocols reviews rational protein design strategies and directed evolutionary techniques, and their impact on protein engineering. The first section presents design and computational strategies for protein engineering focusing on designing a protein with desired properties, including examples covering a wide range of engineering techniques, such as protein-protein interactions, DNA binding, antibody mimics, and enzymatic activity. The second section on evolutionary techniques provides step-by-step instructions on library design and statistical assessment of library quality. New methods for DNA shuffling as well as different selection strategies are also presented.Following the successful Methods in Molecular Biologyв„ў series format, this volume provides a comprehensive guide to the methods used at every stage of the engineering process. By combining a thorough theoretical foundation with detailed protocols, Protein Engineering Protocols will be invaluable to all research workers in the area, from graduate students to senior investigators.
Автор: K. Dane Professor Wittrup Название: Protein Engineering for Therapeutics, Part A,502 ISBN: 0124160395 ISBN-13(EAN): 9780124160392 Издательство: Elsevier Science Рейтинг: Цена: 17903 р. Наличие на складе: Поставка под заказ.
Описание: This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters providean invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds
Описание: A medical text that represents accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. It helps thousands of practitioners and students to an understanding of the drugs essential to preventing, diagnosing, and treating disease.
Описание: This volume provides an overview of mass spectrometry techniques for the analysis of protein therapeutics, structural identification strategies, and quantitative approaches. Studies involving the characterization of process-related protein drug impurities are also discussed.
Автор: Park Название: Protein Engineering and Design ISBN: 1420076582 ISBN-13(EAN): 9781420076585 Издательство: Taylor&Francis Рейтинг: Цена: 23375 р. Наличие на складе: Поставка под заказ.
Описание: The emerging use of the computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering at large. However, because the structure and function of protein molecules are coupled at the molecular level, many critical questions are left unanswered and many of the intricate design rules unclear. This book de-mystifies computational analysis by providing a lucid description of computation’s role in protein engineering and tracing the history of protein design.
Автор: Lutz Название: Protein Engineering Handbook ISBN: 352731850X ISBN-13(EAN): 9783527318506 Издательство: Wiley Цена: 41250 р. Наличие на складе: Поставка под заказ.
Описание: The first complete reference on the engineering and design of proteins covers the full spectrum of current concepts, methods and application areas of this growing field in the biosciences. The first part lays the groundwork by introducing the key factors and relationships governing protein structure and function, rounded off by a survey of current genomics and metagenomics approaches. The second part is dedicated to methodology, from de novo design by modeling to directed evolution and other combinatorial approaches to issues in upscaling for large-scale operations in industry. The third part covers current and future applications of protein engineering, including design strategies for more stable or more specific proteins, as well as successful examples from a wide range of application areas such as biosensors, cyclic peptides, and biomaterials. In summary, this unique work ties together a wide range of knowledge from different sources for a highly practice-oriented handbook for protein engineers in academia and industry alike.
Автор: Lutz Stefan Название: Protein Engineering Handbook ISBN: 3527331239 ISBN-13(EAN): 9783527331239 Издательство: Wiley Рейтинг: Цена: 23375 р. Наличие на складе: Поставка под заказ.
Описание: Introduces innovative and commercially important approaches to engineer novel and improved proteins for diverse applications in biotechnology, chemistry, bioanalytics and medicine. The topics chosen ideally complement the previous two-volume handbook by the same authors.
Описание: A long-standing icon in the fields of enzymology, protein folding, and protein engineering, Sir Alan Fersht is also one of the world`s greatest protein chemists, whose work has been extensively recognized by international awards in both chemistry and molecular biology. This book features a collection of his scientific articles.
Автор: Godara Hemant Название: Washington Manual of Medical Therapeutics ISBN: 1451191952 ISBN-13(EAN): 9781451191950 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 4943 р. Наличие на складе: Невозможна поставка.
Описание: Established for over 65 years as the must-have reference on the medical ward, The Washington Manual® of Medical Therapeutics is now in its 34th edition and builds upon that proud tradition—with even more of the current information you need, deli
Описание: EBOOK NOW AVAILABLE FOR ANDROID!For the past 65 years, The Washington Manual® of Medical Therapeutics, now in its Thirty-Fourth Edition, has been one of the best selling medical texts in the world. It builds upon that proud tradition--with even m
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