Автор: Cedric Raine Название: Multiple Sclerosis ISBN: 0702028118 ISBN-13(EAN): 9780702028113 Издательство: Elsevier Science Рейтинг: Цена: 12197 р. 15246.00-20% Наличие на складе: Есть (1 шт.) Описание: Multiple sclerosis has changed into a condition necessitating a multi-disciplinary approach to both its management and understanding. This book reflects on these developments, including contributions from genetics, immunology and molecular biology. It describes the drugs, both approved or in advanced stages of clinical trials.
Автор: Cohen Название: Multiple Sclerosis Therapeutics ISBN: 0521766273 ISBN-13(EAN): 9780521766272 Издательство: Cambridge Academ Рейтинг: Цена: 25473 р. Наличие на складе: Есть (1 шт.) Описание: This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.
Описание: A synthesis of current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of MRI, magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research and its applications to specific immunotherapies, and the use of immune markers for tracking the disease.
Автор: Rodriguez, Moses; Kantarci, Orhun H.; Pirko, Istva Название: Multiple Sclerosis ISBN: 0199740461 ISBN-13(EAN): 9780199740468 Издательство: Oxford Academ Рейтинг: Цена: 16092 р. Наличие на складе: Поставка под заказ.
Описание: This latest edition to the `Contemporary Neurology Series` will fill one of the few remaining `neurologic gaps` within the Series. `Multiple Sclerosis,` written solely by Moses Rodriguez, Orhun Kantarci and Istvan Pirko of the Mayo Clinic in Rochester, MN offers proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work.
Автор: Lavi Ehud, Constantinescu Cris S. Название: Experimental Models of Multiple Sclerosis ISBN: 0387255176 ISBN-13(EAN): 9780387255170 Издательство: Springer Рейтинг: Цена: 34649 р. Наличие на складе: Поставка под заказ.
Описание: Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. ItвЂ™s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.
Описание: Multiple Sclerosis: a complex disease requiring sophisticated management Multiple Sclerosis poses labyrinthine challenges. There is no blood test to rely on for diagnosis; clinical acumen is essential. Yet an effective diagnosis only takes you part of t
Описание: Describes and discusses the assessment and treatment techniques applied by Occupational Therapists (OTs) to sufferers from Multiple Sclerosis (MS). This text begins with basic information about MS and follows this with suggestions for assessment and treatment.
Описание: Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.
Автор: Ruggieri Название: Multiple Sclerosis in Childhood ISBN: 3211989307 ISBN-13(EAN): 9783211989302 Издательство: Springer Рейтинг: Цена: 11544 р. Наличие на складе: Поставка под заказ.
Описание: Gives detailed presentations of the protean aspects of Multiple Sclerosis and its rare variants (example Balo`s, Devic`s, Marburg and Schilder`s disease), the clinically isolated syndromes, the acute and chronic parainfectious encephalomyelitides, the Central Nervous System vasculitides and other less common conditions.
Описание: In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.
Описание: This book provides comprehensive and up-to-date information on the neuropsychiatric disturbances that may be experienced by patients with multiple sclerosis. The first section is designed primarily to describe the general clinical aspects of multiple sclerosis, from epidemiology to assessment tools.
Описание: Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis.Over the pastfive years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.
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