Описание: The book aims to present, educate and inform individuals about Alzheimer`s disease in a comprehensive manner.
Автор: Khan, Tapan Название: Biomarkers in Alzheimer`s Disease ISBN: 0128048328 ISBN-13(EAN): 9780128048320 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Biomarkers in Alzheimer's Disease provides a comprehensive overview of all modalities of Alzheimer's disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer's disease and technological advancement of biomarkers techniques.
The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer's disease, and for differential diagnosis of Alzheimer's disease with other non-Alzheimer's dementia.
Автор: Wolfe, Michael,S, Название: Developing Therapeutics for Alzheimer`s Disease ISBN: 012802173X ISBN-13(EAN): 9780128021736 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area.
Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer's disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer's disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics.
Автор: Michael R. D`Andrea Название: Intracellular Consequences of Amyloid in Alzheimer`s Disease ISBN: 0128042567 ISBN-13(EAN): 9780128042564 Издательство: Elsevier Science Рейтинг: Цена: 8083.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: . Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. . Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.
Автор: Orly Lazarov Название: Genes, Environment and Alzheimer`s Disease ISBN: 0128028513 ISBN-13(EAN): 9780128028513 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. . It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.
Автор: Amy Borenstein Название: Alzheimer`s Disease ISBN: 0128045388 ISBN-13(EAN): 9780128045381 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach.
At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease.
Reviews the current science surrounding Alzheimer's disease
Provides a primer of foundational knowledge on the disease's epidemiology and biostatistics
Utilizes a life-course approach, providing a novel and integrated view of the evolution of this illness from genes to brain reserve
Uses the 'threshold model'--a theory first described by Dr. Mortimer and widely accepted today--which incorporates the idea of risk factors for the pathology and expression of the disease
Proposes that improving brain health through modifiable behaviors can delay disease onset until a later age
Examines the future of prevention of Alzheimer's disease, a subject of great current interest
Автор: Agronin Marc E Название: Alzheimer`s Disease and Other Dementias ISBN: 0415857007 ISBN-13(EAN): 9780415857000 Издательство: Taylor&Francis Рейтинг: Цена: 7961.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Enriched by case studies from his own career, Dr. Agronin creates a volume full of humanity, insight, and knowledge that is sure to inform and improve the habits and methods of any clinician who deals with Alzheimer`s s disease and other forms of dementia.
Автор: Dennis J. Selkoe; Antoine Triller Название: Synaptic Plasticity and the Mechanism of Alzheimer`s Disease ISBN: 3642095194 ISBN-13(EAN): 9783642095191 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A biochemical hypothesis - that Alzheimer`s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
Автор: Becker Название: Alzheimer`s Disease ISBN: 0844816590 ISBN-13(EAN): 9780844816593 Издательство: Taylor&Francis Рейтинг: Цена: 32155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines the relevance of current research for the early diagnosis of Alzheimer disease. It uncovers the present lack of clinical utility in research methodologies such as neuroimaging, drug challenges, electroencephalographs studies, and brain biopsy.
Автор: Budson Название: The Handbook of Alzheimer`s Disease and Other Dementias ISBN: 1118672852 ISBN-13(EAN): 9781118672853 Издательство: Wiley Рейтинг: Цена: 4744.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a broad-ranging review of the current research on Alzheimer`s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances in a single volume.
Описание: The Aim And Scope Of This Book Is To Review Current Information On Human Development And Processes Of Differentiation That Have Benefited From Breakthrough Analyses In Stem Cell Biology, Elucidation Of Genome And Gene Architecture And Aspects Of Regulation Of Gene Expression, Analysis Of Signaling Systems And Transcription Factor Actions.Insights Into Actions Of Specific Genes And Their Roles In Development Have Been Gathered Through Studies In Patients With Specific Birth Defects, Including Congenital Malformations, Metabolic Defects And Functional Impairments.The Book Is Organized Into Three Sections, The First Dealing With Aspects Of Genomics, Gene Structure And Regulation, Analysis Of Signaling And Function Of Specific Organelles. The Second Section Deals With Molecular Aspects Of Development Of Specific Organs And Structures Such As, Bone, Face, Brain, Heart, Liver, Pancreas, Kidney. The Last Section Deals With Specific Malformations And Tumors That Provide Insight Into Regulation Of Growth. Environmental Factors That Impact Growth And Development Are Also Covered.
Автор: Gozes, Illana Название: Neuroprotection in Alzheimer`s Disease ISBN: 0128036907 ISBN-13(EAN): 9780128036907 Издательство: Elsevier Science Рейтинг: Цена: 17685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. . This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics.
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