Контакты/Адрес/Проезд   Доставка и Оплата
История
  +7(495) 980-12-10
  10:00-18:00 пн-сб
  shop@logobook.ru
   
    Поиск книг                    Поиск по списку ISBN Расширенный поиск    
Найти
  Зарубежные издательства Российские издательства  
Авторы | Каталог книг | Издательства | Новинки | Учебная литература | Специальные предложения | Бестселлеры
 
Читайте отзывы покупателей и оценивайте качество магазина на Яндекс.Маркете
Информация
Online Каталоги
Каталог учебной литературы
по английскому языку >>>

Каталог учебной литературы
по английскому языку >>>


Introduction to Biological and Small Molecule Drug Research and D, Robin Ganellin


Варианты приобретения
Цена: 6307р.   7008р. -10%
Кол-во:
Наличие: Отсутствует. Возможна поставка под заказ.

При оформлении заказа до: 1 ноя 2019
Ориентировочная дата поставки: конец Ноября
При условии наличия книги у поставщика.

Добавить в корзину
в Мои желания
Автор: Robin Ganellin
Название:  Introduction to Biological and Small Molecule Drug Research and D
Издательство: Elsevier Science
Классификация:
Производственные отрасли промышленности
Фармакология
Органическая химия
Промышленная химия

ISBN: 0123971764
ISBN-13(EAN): 9780123971760
ISBN: 0-12-397176-4
ISBN-13(EAN): 978-0-12-397176-0
Обложка/Формат: Hardcover
Страницы: 472
Вес: 1.116 кг.
Дата издания: 29.05.2013
Серия: Chem & Chem Eng
Язык: ENG
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Англии
Описание: Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.
Дополнительное описание:




Introduction to Drug Synthesis

Автор: Patrick Graham
Название: Introduction to Drug Synthesis
ISBN: 0198708432 ISBN-13(EAN): 9780198708438
Издательство: Oxford Academ
Рейтинг:
Цена: 3746 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

The Sodium-Hydrogen Exchanger / From Molecule to its Role in Disease

Автор: Karmazyn Morris, Avkiran Metin, Fliegel Larry
Название: The Sodium-Hydrogen Exchanger / From Molecule to its Role in Disease
ISBN: 1402074743 ISBN-13(EAN): 9781402074745
Издательство: Springer
Рейтинг:
Цена: 17297 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume contains state-of-the-art reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance. *Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical. *Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms. *Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors. The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease will be of interest to pharmacologists, physiologists, biochemists, cell and molecular biologists and clinical scientists interested in new therapeutic concepts related to sodium-hydrogen exchange inhibition.

Design of Hybrid Molecules for Drug Development

Автор: Decker, Michael
Название: Design of Hybrid Molecules for Drug Development
ISBN: 0081010117 ISBN-13(EAN): 9780081010112
Издательство: Elsevier Science
Рейтинг:
Цена: 12454 р. 13838.00 -10%
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. . Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.

Introduction to Drug Disposition and Pharmacokinetics

Автор: Curry Stephen H.
Название: Introduction to Drug Disposition and Pharmacokinetics
ISBN: 111926104X ISBN-13(EAN): 9781119261049
Издательство: Wiley
Рейтинг:
Цена: 5220 р.
Наличие на складе: Поставка под заказ.

Описание: The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones.

Single Molecule Chemistry and Physics / An Introduction

Автор: Wang C., Bai C.
Название: Single Molecule Chemistry and Physics / An Introduction
ISBN: 3540253696 ISBN-13(EAN): 9783540253693
Издательство: Springer
Рейтинг:
Цена: 17476 р.
Наличие на складе: Поставка под заказ.

Описание: The characterization of individual molecules has been a scientifically attractive and challenging task for decades, and remains so today. New technological developments have facilitated great progress in our understanding of the structure and behavior of single atoms and molecules in various environments. This book provides an introduction to the most important experimental and theoretical methods for characterizing and imaging single molecules, including scanning tunnelling and atomic force microscopy of molecules at surfaces, fluorescence studies, near-field optical microscopy and Raman spectroscopy. It also elucidates newly discovered properties of single-molecular systems and their relevance to the fast growing field of nanotechnology.

Small Molecule Medicinal Chemistry: Strategies and Technologies

Автор: Werngard Czechtizky,Peter Hamley
Название: Small Molecule Medicinal Chemistry: Strategies and Technologies
ISBN: 1118771605 ISBN-13(EAN): 9781118771600
Издательство: Wiley
Рейтинг:
Цена: 11913 р.
Наличие на складе: Поставка под заказ.

Описание: Small molecules are the major source for marketed therapeutic drugs and valuable tools for studying biological pathways. To identify new small molecule therapeutics in an increasingly competitive environment, researchers need to keep up?€“to?€“date with t

Metallobiochemistry, Part B: Metallothionein and Related Molecule

Автор: John N. Abelson
Название: Metallobiochemistry, Part B: Metallothionein and Related Molecule
ISBN: 0121821064 ISBN-13(EAN): 9780121821067
Издательство: Elsevier Science
Рейтинг:
Цена: 5138 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Providing up-to-date, state-of-the-art methods for determining the metal content of metalloenzymes, metalloproteins, and other metallobiochemicals, this text emphasizes the need for control of contamination, as well as techniques for handling and dealing with contamination-sensitive molecules.

From Small Organic Molecules to Large: A Century of Progress

Автор: Mark, H.
Название: From Small Organic Molecules to Large: A Century of Progress
ISBN: 0841217769 ISBN-13(EAN): 9780841217768
Издательство: Oxford Academ
Рейтинг:
Цена: 3434 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: An autobiography of the late Herman F. Mark, one of the eminent chemists included in the series, "Profiles, Pathways and Dreams". Mark was internationally known for his research on the synthesis, structure, characterization, reactions and properties of natural and synthetic polymers.

Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies

Автор: Bernard Testa
Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies
ISBN: 3906390225 ISBN-13(EAN): 9783906390222
Издательство: Wiley
Рейтинг:
Цена: 15153 р.
Наличие на складе: Поставка под заказ.

Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.

Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules

Автор: Faller
Название: Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules
ISBN: 3527323317 ISBN-13(EAN): 9783527323319
Издательство: Wiley
Рейтинг:
Цена: 19333 р.
Наличие на складе: Поставка под заказ.

Описание: A reference on methods to generate pharmacokinetic and safety profiles of drug candidates, and how they must be balanced against one other for the best selection of candidates for further development. It presents an introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development.

Introduction to Nutrition and Health Research

Автор: Koh Eunsook T., Owen Willis L.
Название: Introduction to Nutrition and Health Research
ISBN: 0792379837 ISBN-13(EAN): 9780792379836
Издательство: Springer
Цена: 17476 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Introduction to Nutrition and Health Research aims to fill a critical gap in dietetics, nutrition and health education literature by providing a comprehensive guide to conducting research and understanding the research of others. Using actual articles, this book teaches how researchers identified problems; how they framed those problems; and how they reported, interpreted and implemented their findings. Step by step, the chapters cover an overview of the process, statistical and measurement concepts, types of research (including experimental, quasi-experimental, descriptive, and qualitative research), how to present results and computer techniques for data analysis. While this book is primarily aimed at masters and doctoral level students and beginning researchers, it will also have strong appeal for teachers, technicians and counselors.

Dna And Rna Binders, Volume 1, From Small Molecules To Drugs

Автор: Dna And Rna Binders, Volume 1, From Small Molecules To Drugs
Название: Dna And Rna Binders, Volume 1, From Small Molecules To Drugs
ISBN: 3527305955 ISBN-13(EAN): 9783527305957
Издательство: Wiley
Цена: 26125 р.
Наличие на складе: Поставка под заказ.

Описание: The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.


ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
   В Контакте  Мобильная версия