Описание: This volume contains state-of-the-art reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance. *Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical. *Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms. *Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors. The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease will be of interest to pharmacologists, physiologists, biochemists, cell and molecular biologists and clinical scientists interested in new therapeutic concepts related to sodium-hydrogen exchange inhibition.
Описание: The characterization of individual molecules has been a scientifically attractive and challenging task for decades, and remains so today. New technological developments have facilitated great progress in our understanding of the structure and behavior of single atoms and molecules in various environments. This book provides an introduction to the most important experimental and theoretical methods for characterizing and imaging single molecules, including scanning tunnelling and atomic force microscopy of molecules at surfaces, fluorescence studies, near-field optical microscopy and Raman spectroscopy. It also elucidates newly discovered properties of single-molecular systems and their relevance to the fast growing field of nanotechnology.
Описание: Small molecules are the major source for marketed therapeutic drugs and valuable tools for studying biological pathways. To identify new small molecule therapeutics in an increasingly competitive environment, researchers need to keep up?€“to?€“date with t
Описание: Providing up-to-date, state-of-the-art methods for determining the metal content of metalloenzymes, metalloproteins, and other metallobiochemicals, this text emphasizes the need for control of contamination, as well as techniques for handling and dealing with contamination-sensitive molecules.
Описание: An autobiography of the late Herman F. Mark, one of the eminent chemists included in the series, "Profiles, Pathways and Dreams". Mark was internationally known for his research on the synthesis, structure, characterization, reactions and properties of natural and synthetic polymers.
Описание: The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones.
Описание: The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Описание: Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. . Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
Описание: A reference on methods to generate pharmacokinetic and safety profiles of drug candidates, and how they must be balanced against one other for the best selection of candidates for further development. It presents an introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development.
Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Описание: Introduction to Nutrition and Health Research aims to fill a critical gap in dietetics, nutrition and health education literature by providing a comprehensive guide to conducting research and understanding the research of others. Using actual articles, this book teaches how researchers identified problems; how they framed those problems; and how they reported, interpreted and implemented their findings. Step by step, the chapters cover an overview of the process, statistical and measurement concepts, types of research (including experimental, quasi-experimental, descriptive, and qualitative research), how to present results and computer techniques for data analysis. While this book is primarily aimed at masters and doctoral level students and beginning researchers, it will also have strong appeal for teachers, technicians and counselors.
Автор: Patrick Graham Название: Introduction to Drug Synthesis ISBN: 0198708432 ISBN-13(EAN): 9780198708438 Издательство: Oxford Academ Рейтинг: Цена: 6572 р. Наличие на складе: Поставка под заказ.
Описание: An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.
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