Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Автор: Jeffrey Kordower Название: CNS Regeneration, ISBN: 0123739942 ISBN-13(EAN): 9780123739940 Издательство: Elsevier Science Рейтинг: Цена: 21559.00 р. Наличие на складе: Поставка под заказ.
Описание: Focuses on the field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. This book covers numerous areas in detail, and gives special emphasis to discussions of movement disorders such as Parkinson`s disease, Alzheimer`s disease, and spinal cord injury.
Автор: Uchida Название: Neuroprotection and Regeneration of the Spinal Cord ISBN: 4431545018 ISBN-13(EAN): 9784431545019 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury.
Автор: Stefano Schiaffino; Terence Partridge Название: Skeletal Muscle Repair and Regeneration ISBN: 1402067674 ISBN-13(EAN): 9781402067679 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Skeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body`s main store of carbohydrate and protein as well as being one of the principal generators of heat. This volume presents the collective experience of major research groups investigating various aspects of muscle cell biology.
Автор: Stefano Schiaffino; Terence Partridge Название: Skeletal Muscle Repair and Regeneration ISBN: 9048177189 ISBN-13(EAN): 9789048177189 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles.
Автор: H.D. Perez; B. Mitrovic; A. Baron Van Evercooren Название: Opportunities and Challenges of the Therapies Targeting CNS Regeneration ISBN: 3642421482 ISBN-13(EAN): 9783642421488 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair.- White Matter Progenitor Cells Reside in an Oligodendrogenic Niche.- At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo.- Remyelination and Restoration of Axonal Function by Glial Cell Transplantation.- Gene and Stem Cell Therapy for Autoimmune Demyelination.- Novel Gene Therapeutic Strategies for Neurodegenerative Diseases.- Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis.
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