Автор: Penney; David G. Название: Carbon Monoxide Toxicity ISBN: 0849320658 ISBN-13(EAN): 9780849320651 Издательство: Informa Рейтинг: Цена: 34238 р. Наличие на складе: Нет в наличии.
Описание: Edited by one of the world's top CO experts, Carbon Monoxide Toxicity compiles scientific information and clinical research to address the gamut of health-related CO issues. Lauded by reviewers as a seminal text, it details the history of studies and explains the hidden threat of chronic low-level exposure that has made CO the leading agent in US poisoning deaths. The broad themes center on clinical management of various forms of CO poisoning and education of the public on its constant danger. The book provides a thorough review for all toxicologists, regulators, and investigators, but is especially valuable to those involved with pulmonary or combustion toxicology.
Автор: Weiner/Kotkoski Название: Excipient Toxicity & Safety ISBN: 0824782100 ISBN-13(EAN): 9780824782108 Издательство: Informa Рейтинг: Цена: 38803 р. Наличие на складе: Нет в наличии.
Описание: This book reviews the history, regulatory status, pharmacopeial specifications, and harmonization of pharmaceutical excipients in the United States and Europe, and provides a comprehensive understanding of the current scientific basis for safety evaluation and risk assessment. Examines excipients as a unique class of products and explores new procedures for determining toxicity! A timely and unique addition to the pharmaceutical literature, containing over 570 citations that support and enhance the text, Excipient Toxicity and Safety
identifies the differences between excipients (inactive ingredients), food ingredients, and drug products
evaluates issues of dose administration, species selection, and study design for various routes of exposure
provides detailed information on the historical uses of excipients in drug formulations
clarifies the Safety Committee of the International Pharmaceutical Excipients Council's (IPEC) guidelines and technical specifications for conducting tests for each route of exposure
explains how data generated in toxicity models are applied to identify hazards in drug formulations
details exposure assessment to link hazard identification with risk
considers the requirements and importance of purity specifications
and much more! Excipient Toxicity and Safety is a blue-ribbon reference ideal for pharmacists; toxicologists; pharmacologists; analytical chemists; quality control, quality assurance, and regulatory compliance managers; and upper-level undergraduate and graduate students in these disciplines.
Описание: * This is the first book to address the problem of quantifying uncertainty in dose response relations for toxic substances. * Each chapter is reviewed and critiqued from three viewpoints: risk analyst / regulator; statistician / mathematician; toxicologist / epidemiologist.
Автор: Yinon; Jehuda Название: Toxicity and Metabolism of Explosives ISBN: 0849351286 ISBN-13(EAN): 9780849351280 Издательство: Taylor&Francis Рейтинг: Цена: 13750 р. Наличие на складе: Поставка под заказ.
Описание: During 215 days of WWI, some 17,000 TNT poisoning cases (with 475 deaths) occurred. Yinon (Weizmann Institute of Science) has assembled information on human toxicity of explosives including symptoms, clinical manifestations, and toxic effects. He covers animal studies, and those on metabolism and degradation. Environmental corruption and analysis
Описание: In establishing how certain chemicals can cause behavioural disorders, the process of neurotoxicity risk assessment poses significant challenges to every
discipline within neuroscience. In this volume, leaders from industrial, academic, and government settings share insights on behavioural measurement in neurotoxicity risk assessment,
and address the critical scientific issues arising from the expanding role of neurobehavioral toxicology in public policy development. The authors set out to provide a comprehensive and
authoritative review of current methods in the analysis and interpretation of neurobehavioural toxicology.
Coverage begins with a discussion of criteria for determining
neurotoxic potential. The next section examines neurobehavioural evaluations in developmental neurotoxicity. Subsequent sections focus on activity and observational data and
applications of schedule-controlled operant behaviour in toxicity testing.
The contributors address controversies surrounding the suitability and interpretation of procedures
designed for neurotoxicological assessments. Some case studies are also included.
Описание: This work focuses primarily on identifying the research needs in this area of neurotoxicology. Based on papers presented for the International Symposium on
Aluminium Toxicity, held in Vancouver in 1995, it reviews the knowledge and research required in each specific area.
Описание: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section
considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The
second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of
The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Описание: This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses.
Описание: This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of
Автор: Akcakaya, H. Resit; Stark, John D.; Bridges, Todd Название: Demographic Toxicity ISBN: 0195332962 ISBN-13(EAN): 9780195332964 Издательство: Oxford Academ Рейтинг: Цена: 11093 р. Наличие на складе: Поставка под заказ.
Описание: Each chapter of this edited volume describes the application of a population model to a particular species. The book demonstrates how various life history characteristics of the species are incorporated into the model, how ecotoxicological impacts are modeled, and how the results of the model has been or can be used in risk assessment. A powerful software tool is included.
Автор: Wolfgang Dekant Название: Tissue-Specific Toxicity, ISBN: 0122088603 ISBN-13(EAN): 9780122088605 Издательство: Elsevier Science Рейтинг: Цена: 26565 р. Наличие на складе: Поставка под заказ.
Описание: Provides a review of the molecular mechanisms of toxicity. This work includes individual chapters that deal with specific aspects of toxicity problems associated with selected organs. It contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organs.
Описание: High-throughput assays are part of a paradigm shift, to more cost-effective and reliable methods, in the testing of chemical and drug safety. This book covers methods, data generation, data analysis, and applications in risk assessment for major toxic
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