Автор: Sherman Irwin W Название: Malaria Vaccines: The Continuing Quest ISBN: 1786340046 ISBN-13(EAN): 9781786340047 Издательство: World Scientific Publishing Рейтинг: Цена: 17424.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.
Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.
This book chronicles the development of RTS, S -- done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation -- as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.
This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.
Описание: Presents an overview of the complex biological systems used within a global public health setting and features a focus on malaria analysis Bridging the gap between agent–based modeling and simulation (ABMS) and geographic information systems (GIS), Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology provides a useful introduction to the development of agent–based models (ABMs) by following a conceptual and biological core model of Anopheles gambiae for malaria epidemiology. Using spatial ABMs, the book includes mosquito (vector) control interventions and GIS as two example applications of ABMs, as well as a brief description of epidemiology modeling. In addition, the authors discuss how to most effectively integrate spatial ABMs with a GIS. The book concludes with a combination of knowledge from entomological, epidemiological, simulation–based, and geo–spatial domains in order to identify and analyze relationships between various transmission variables of the disease. Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology also features: Location–specific mosquito abundance maps that play an important role in malaria control activities by guiding future resource allocation for malaria control and identifying hotspots for further investigation Discussions on the best modeling practices in an effort to achieve improved efficacy, cost–effectiveness, ecological soundness, and sustainability of vector control for malaria An overview of the various ABMs, GIS, and spatial statistical methods used in entomological and epidemiological studies, as well as the model malaria study A companion website with computer source code and flowcharts of the spatial ABM and a landscape generator tool that can simulate landscapes with varying spatial heterogeneity of different types of resources including aquatic habitats and houses Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology is an excellent reference for professionals such as modeling and simulation experts, GIS experts, spatial analysts, mathematicians, statisticians, epidemiologists, health policy makers, as well as researchers and scientists who use, manage, or analyze infectious disease data and/or infectious disease–related projects. The book is also ideal for graduate–level courses in modeling and simulation, bioinformatics, biostatistics, public health and policy, and epidemiology. S. M. Niaz Arifin, PhD, is Research Assistant Professor in the Department of Computer Science and Engineering at the University of Notre Dame. A member of The Society for Computer Simulation, and American Society of Tropical Medicine and Hygiene, and the recipient of The American Society of Tropical Medicine and Hygiene Travel Award in 2011, his research interests include agent–based modeling and simulation, public health, data warehousing, and geographic information systems. Gregory R. Madey, PhD, is Research Professor in the Department of Computer Science and Engineering at the University of Notre Dame. A member of The Society for Computer Simulation, Institute of Electrical and Electronics Engineers Computer Society, and American Society of Tropical Medicine and Hygiene, his research interests include agent–based modeling and simulation, cyberinfrastructure, bioinformatics, biocomplexity, e–Technologies, open source software, disaster management, and health informatics. Frank H. Collins, PhD, is Professor in the Department of Biological Sciences at the University of Notre Dame. His research interests include genome level studies of arthropod vectors of human pathogens, the biology of malaria vectors with a focus on the development of molecular tools that will permit better resolution of questions about vector population ec
Автор: Henry M. Staines; Sanjeev Krishna Название: Treatment and Prevention of Malaria ISBN: 3034808089 ISBN-13(EAN): 9783034808088 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.
Автор: Zach N. Adelman Название: Genetic Control of Malaria and Dengue ISBN: 0128002468 ISBN-13(EAN): 9780128002469 Издательство: Elsevier Science Рейтинг: Цена: 11115.00 р. Наличие на складе: Поставка под заказ.
Описание:
Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies.
For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown.
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