Robert N. Eisenman The Myc/Max/Mad Transcription Factor Network 9783642421419

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Автор: Robert N. Eisenman
Название: The Myc/Max/Mad Transcription Factor Network
ISBN: 9783642421419
Издательство: Springer
Классификация:

Медицинская генетика

Медицинская микробиология и вирусология

ISBN-10: 3642421415
Обложка/Формат: Paperback
Страницы: 298
Вес: 0.46 кг.
Дата издания: 2006
Серия: Current Topics in Microbiology and Immunology
Язык: English
Издание: 2006 ed.
Иллюстрации: 3 tables, black and white; vii, 282 p.
Размер: 234 x 156 x 16
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the “big picture” and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms.
Дополнительное описание: Making Myc.- Transcriptional Activation by the Myc Oncoprotein.- Mechanisms of Transcriptional Repression by Myc.- The Mad Side of the Max Network: Antagonizing the Function of Myc and More.- Structural Aspects of Interactions Within the Myc/Max/Mad Netwo

The Myc/Max/Mad Transcription Factor Network, Robert N. Eisenman