Intestinal Inflammation and Colorectal Cancer, C. Gasche; M. Gassull; J.M. Herrer?as Guti?rrez; E
Автор: Serguei V. Kozlov (Ed.) Название: Inflammation and Cancer ISBN: 1603275290 ISBN-13(EAN): 9781603275293 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Addresses various aspects of experimental cancer biology, focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. This title describes experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development.
Автор: Beauchemin Название: Metastasis of Colorectal Cancer ISBN: 9048188326 ISBN-13(EAN): 9789048188321 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers colon cancer metastasis from fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, and more.
Описание: Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs.
Описание: Large-section histopathology widens your perspectives...Correct diagnosis and staging are essential in determining the appropriate therapy of colorectal carcinoma, one of the most common malignancies in America and Europe. As medical science continues to develop rapidly, histopathology remains an essential part of diagnosis in most malignant diseases. In this era of interdisciplinary medicine, the role of pathology has expanded to provide images that easily correlate with endoscopic, radiological, or operative findings.In this remarkable atlas, Tibor Tot presents colon pathology in large histological sections, with cross-sections of entire tumors in their anatomic environments and their circumferential surgical margins. These unique images form a guide to diagnosis, tumor typing and staging according to TNM criteria. They help to assess the completeness of a surgical excision and to understand the heterogeneity of colorectal carcinomas. Features:- Cases illustrated in two-page spreads with clinical information, conventional histopathology, and large-section histology images enlarged to almost a full page. - Pathology seen in the context of surrounding tissues- The margins of malignant tumors visible in their entirety- Schematic guides to interpretation of the large-section images - Emphasis on diagnostic advantages of using large section technique- Technical guidelines for obtaining large-section histopathology specimensThis atlas is the result of seven years of studying almost 2,000 cases of colorectal carcinoma and other intestinal lesions and is highly recommended for pathologists, radiologists, surgeons, and oncologists alike.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis.
This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.
Presents the most advanced information regarding the role of the autophagic system in life and death
Contains a direct focus on the role of a novel binuclear palladacycle complex that inhibits melanoma growth
Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities
Edited work with chapters authored by leaders in the field from around the globe--the broadest, most expert coverage available
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to both cellular processes whilehelping researchers to explore their potentially important connections.
Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials (cellular cargo) and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes (hydrolases) that breakdown proteins, lipids, carbohydrates, etc. (self-digestion). To further explain this phenomenon, the role of endoplasmic reticulum (ER) in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, which are discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained.
Volume 9 also includes an explanation of the role of autophagy-related gene "ATG5" in cancer (e.g., gastrointestinal cancer). Paradoxically, autophagy is a double-edged sword, because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers as a concise overview of the role of autophagy in necrosis and inflammation, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.
Volumes in the Series
Volume 1: Molecular Mechanisms. Elucidates autophagy s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn s Disease, Gaucher Disease, Huntington s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy s effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host
Описание: This book reviews and discusses knowledge gathered on Metabolic Syndrome and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. It focuses on recent discoveries and progress toward possible therapeutic strategies.
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