Cholesterol Binding and Cholesterol Transport Proteins:, J. Robin Harris
Автор: J. Robin Harris Название: Cholesterol Binding and Cholesterol Transport Proteins: ISBN: 9048186218 ISBN-13(EAN): 9789048186211 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance. This books examines the structural and functional aspects of the families of cholesterol-binding and cholesterol transport proteins.
Автор: Permyakov Название: Calcium Binding Proteins ISBN: 0470525843 ISBN-13(EAN): 9780470525845 Издательство: Wiley Рейтинг: Цена: 25019.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution.
Описание: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.
Автор: Robert K. Poole Название: Recent Advances in Microbial Oxygen-Binding Proteins,67 ISBN: 0128032987 ISBN-13(EAN): 9780128032985 Издательство: Elsevier Science Рейтинг: Цена: 20886.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This latest volume in Advances in Microbial Physiology continues the long tradition of topical and important reviews in microbiology. Contains contributions from leading authorities in the field of microbial physiology Informs and updates on all the latest developments in the field
Автор: Martino Bolognesi; Guido di Prisco; Cinzia Verde Название: Dioxygen Binding and Sensing Proteins ISBN: 8847015634 ISBN-13(EAN): 9788847015630 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is dedicated to Jonathan and Bea Wittenberg, giants in the field of haeme protein research. It provides the latest achievements and information in the structure, physiology, and evolution applied on dioxygen-binding and sensing proteins.
Автор: Teresa Carlomagno Название: Tubulin-Binding Agents ISBN: 3642435947 ISBN-13(EAN): 9783642435942 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
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