Long Non-Coding RNAs, ?ur?ica Ugarkovi?

Автор: ?rom
Название: Enhancer RNAs
ISBN: 1493940333 ISBN-13(EAN): 9781493940332
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume provides a comprehensive overview of the experimental and computational methodologies used to study the function of long non-coding RNA (ncRNAs) expressed from enhancers. Chapter detail both wet-lab and dry-lab techniques and annotating long ncRNAs and exploring transcription by assessing where transcription starts and generally how it occurs.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Enhancer RNAs: Methods and Protocols aims to ensure successful results in this rapidly developing field.

Автор: Jensen
Название: RNA Exosome
ISBN: 1441978402 ISBN-13(EAN): 9781441978400
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Assembling work by prominent researchers in the field of RNA exosomes, this excellent introduction to the fascinating protein complex provides a comprehensive account of the proteins` many functions as well as a historical account of the field`s development.

Автор: Zhang
Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells
ISBN: 1607617684 ISBN-13(EAN): 9781607617686
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.

Автор: Howard
Название: RNA Interference from Biology to Therapeutics
ISBN: 1461447437 ISBN-13(EAN): 9781461447436
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This volume addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. It covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects.

Автор: Song
Название: The Long and Short Non-coding RNAs in Cancer Biology
ISBN: 9811014965 ISBN-13(EAN): 9789811014963
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Автор: Slaby
Название: Non-coding RNAs in Colorectal Cancer
ISBN: 3319420577 ISBN-13(EAN): 9783319420578
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: Non Coding RNAs in Plants
ISBN: 3642269990 ISBN-13(EAN): 9783642269998
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Discovered just 20 years ago, ncRNAs have been dubbed the `secret regulators` of cells. Only recently has their function in plants been investigated. In this book leading researchers relate recent discoveries about the role played by small ncRNA in plants.