Описание: Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. This book offers a tool box for those who have a general interest in biomarker research.
Автор: Li Название: Heterocyclic Chemistry in Drug Discovery ISBN: 1118148908 ISBN-13(EAN): 9781118148907 Издательство: Wiley Рейтинг: Цена: 13272 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go han
Описание: Provides coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals. This book discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. It considers the integration of PK and PD concepts into the biotech drug development plan.
Описание: This is Volume 2: Drug Disvery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
Описание: Describes the tools available for performing various assay techniques. This book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system and troubleshooting tools. It describes biochemical assay classes and non-class specific assay development for cell-based assays.
Описание: Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance Imaging (MRI) is one of the principal imaging modalities because it allows information to be gathered non-invasively. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.
Автор: Rogge Mark C Название: Preclinical Drug Development ISBN: 157444882X ISBN-13(EAN): 9781574448825 Издательство: Informa Рейтинг: Цена: 13010 р. Наличие на складе: Нет в наличии.
Описание: Generic Drug Product Development: Specialty Dosage Forms explores the issues in providing evidence of pharmaceutical equivalence and bioequivalence for specialty drug products. In addition, the book provides various scientific approaches and regulatory requirements for manufacturers to demonstrate the therapeutic equivalence of generic specialty drug products to brand name alternatives. This book discusses measurement of drug product quality and performance, as well as the regulatory and scientific requirements of topical, nasal and inhalation, generic biologics, and other drug products.
Автор: Kanfer Isadore Название: Generic Drug Product Development ISBN: 0849377846 ISBN-13(EAN): 9780849377846 Издательство: Taylor&Francis Рейтинг: Цена: 13063 р. Наличие на складе: Поставка под заказ.
Описание: The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart; generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of a bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, this source discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the chemical composition of the active drug and the nature of the drug product..
Описание: Ibuprofen has become one of the foremost pain–relieving medications world–wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non–pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti–inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor–in–Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non–prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non–inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti–inflammatory and analgesic drugs.
Описание: Many times druwork fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:*Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.*Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.
Описание: Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.
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