Описание: This is Volume 2: Drug Disvery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
Описание: Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.
Описание: Provides coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals. This book discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. It considers the integration of PK and PD concepts into the biotech drug development plan.
Описание: Describes the tools available for performing various assay techniques. This book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system and troubleshooting tools. It describes biochemical assay classes and non-class specific assay development for cell-based assays.
Описание: Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance Imaging (MRI) is one of the principal imaging modalities because it allows information to be gathered non-invasively. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.
Описание: The Process of New Drug Discovery and Development, Second Edition presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new edition reports on the scientific advances in new drug discovery and development for areas such as combinatorial chemistry, screening technologies, metabonomics, and preclinical testing. It also greatly expands its focus on the business aspects of bringing drugs to market and offers coverage of essential topics for companies involved in drug development, such as the financial aspects of establishing a start-up pharmaceutical enterprise, the regulatory process, risk assessment, liability and litigation, and patent law.
Описание: The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are critical to the success of any high-throughput screening (HTS) endeavor. This book discusses assay developments for target classes such as protein kinases and phosphatases, proteases and nuclear receptors.
Описание: Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. This book offers a tool box for those who have a general interest in biomarker research.
Описание: With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book`s fifteen chapters have been written by leading pharmaceutical and analytical scientists.
Автор: Yurong Lai Название: Transporters in Drug Discovery and Development, ISBN: 1907568212 ISBN-13(EAN): 9781907568213 Издательство: Elsevier Science Цена: 18934 р. 21038.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.
Автор: Kenakin, Terry Название: Pharmacology in Drug Discovery and Development ISBN: 0128037520 ISBN-13(EAN): 9780128037522 Издательство: Elsevier Science Рейтинг: Цена: 5466 р. 6073.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. . Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.
Автор: Lednicer Название: New Drug Discovery and Development ISBN: 0470007508 ISBN-13(EAN): 9780470007501 Издательство: Wiley Рейтинг: Цена: 12122 р. Наличие на складе: Поставка под заказ.
Описание: A case history approach to drug synthesis and discovery Discover the origins of some of today`s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval.
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