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Basic Principles of Drug Discovery and Development,, Benjamin Blass



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Автор: Benjamin Blass
Название:  Basic Principles of Drug Discovery and Development,
Издательство: Elsevier Science
Классификация:
Фармакология
Органическая химия
Промышленная химия

ISBN: 012411508X
ISBN-13(EAN): 9780124115088
ISBN: 0-12-411508-X
ISBN-13(EAN): 978-0-12-411508-8
Обложка/Формат: Hardback
Страницы: 448
Вес: 0.956 кг.
Дата издания: 28.04.2015
Язык: ENG
Иллюстрации: Approx. 150 illustrations (50 in full color); illustrations, unspecified
Размер: 154 x 230 x 25
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Англии
Описание: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. . The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property.
Дополнительное описание:




Biomarker Methods in Drug Discovery and Development

Автор: Wang
Название: Biomarker Methods in Drug Discovery and Development
ISBN: 1934115231 ISBN-13(EAN): 9781934115237
Издательство: Springer
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Цена: 17297 р.
Наличие на складе: Нет в наличии.

Описание: Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. This book offers a tool box for those who have a general interest in biomarker research.

Heterocyclic Chemistry in Drug Discovery

Автор: Li
Название: Heterocyclic Chemistry in Drug Discovery
ISBN: 1118148908 ISBN-13(EAN): 9781118148907
Издательство: Wiley
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Цена: 13272 р.
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Описание: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go han

Pharmacokinetics and Pharmacodynamics of Biotech Drugs - Principles and Case Studies in Drug Development

Автор: Meibohm
Название: Pharmacokinetics and Pharmacodynamics of Biotech Drugs - Principles and Case Studies in Drug Development
ISBN: 3527314083 ISBN-13(EAN): 9783527314089
Издательство: Wiley
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Цена: 15675 р.
Наличие на складе: Поставка под заказ.

Описание: Provides coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals. This book discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. It considers the integration of PK and PD concepts into the biotech drug development plan.

Burger`s Medicinal Chemistry and Drug Discovery, Volume 2, Drug Discovery and Drug Development, 6th Edition

Автор: Donald J. Abraham
Название: Burger`s Medicinal Chemistry and Drug Discovery, Volume 2, Drug Discovery and Drug Development, 6th Edition
ISBN: 0471370282 ISBN-13(EAN): 9780471370284
Издательство: Wiley
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Цена: 35530 р.
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Описание: This is Volume 2: Drug Disvery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.

Handbook of Assay Development in Drug Discovery

Автор: Lisa K. Minor
Название: Handbook of Assay Development in Drug Discovery
ISBN: 1574444719 ISBN-13(EAN): 9781574444711
Издательство: Taylor&Francis
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Цена: 17243 р.
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Описание: Describes the tools available for performing various assay techniques. This book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system and troubleshooting tools. It describes biochemical assay classes and non-class specific assay development for cell-based assays.

In Vivo Mr Techniques In Drug Discovery And Development

Автор: Beckmann Nicolau
Название: In Vivo Mr Techniques In Drug Discovery And Development
ISBN: 0849330262 ISBN-13(EAN): 9780849330261
Издательство: Informa
Цена: 14051 р.
Наличие на складе: Невозможна поставка.

Описание: Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance Imaging (MRI) is one of the principal imaging modalities because it allows information to be gathered non-invasively. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.

Preclinical Drug Development

Автор: Rogge Mark C
Название: Preclinical Drug Development
ISBN: 157444882X ISBN-13(EAN): 9781574448825
Издательство: Informa
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Цена: 13010 р.
Наличие на складе: Нет в наличии.

Generic Drug Product Development: Specialty Drug Products (VOL II)

Автор: Shargel
Название: Generic Drug Product Development: Specialty Drug Products (VOL II)
ISBN: 0849377862 ISBN-13(EAN): 9780849377860
Издательство: Taylor&Francis
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Цена: 14108 р.
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Описание: Generic Drug Product Development: Specialty Dosage Forms explores the issues in providing evidence of pharmaceutical equivalence and bioequivalence for specialty drug products. In addition, the book provides various scientific approaches and regulatory requirements for manufacturers to demonstrate the therapeutic equivalence of generic specialty drug products to brand name alternatives. This book discusses measurement of drug product quality and performance, as well as the regulatory and scientific requirements of topical, nasal and inhalation, generic biologics, and other drug products.

Generic Drug Product Development

Автор: Kanfer Isadore
Название: Generic Drug Product Development
ISBN: 0849377846 ISBN-13(EAN): 9780849377846
Издательство: Taylor&Francis
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Цена: 13063 р.
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Описание: The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart; generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of a bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, this source discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the chemical composition of the active drug and the nature of the drug product..

Ibuprofen: Discovery, Development and Therapeutics

Автор: K. D. Rainsford
Название: Ibuprofen: Discovery, Development and Therapeutics
ISBN: 1118743385 ISBN-13(EAN): 9781118743386
Издательство: Wiley
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Цена: 13036 р.
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Описание: Ibuprofen has become one of the foremost pain–relieving medications world–wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non–pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti–inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor–in–Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non–prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non–inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti–inflammatory and analgesic drugs.    

Absorption and Drug Development: Solubility, Permeability, and Charge State

Автор: Alex Avdeef
Название: Absorption and Drug Development: Solubility, Permeability, and Charge State
ISBN: 0471423653 ISBN-13(EAN): 9780471423652
Издательство: Wiley
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Цена: 9086 р.
Наличие на складе: Поставка под заказ.

Описание: Many times druwork fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:*Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.*Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.

From Genome to Therapy: Integrating New Technologies with Drug Development - No. 229

Автор: Novartis Foundation
Название: From Genome to Therapy: Integrating New Technologies with Drug Development - No. 229
ISBN: 0471627445 ISBN-13(EAN): 9780471627449
Издательство: Wiley
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Цена: 15335 р.
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Описание: Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.


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