Basic Principles of Drug Discovery and Development,, Benjamin Blass
Автор: Li Название: Heterocyclic Chemistry in Drug Discovery ISBN: 1118148908 ISBN-13(EAN): 9781118148907 Издательство: Wiley Рейтинг: Цена: 12645 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go han
Автор: Mike S. Lee Название: LC/MS Applications in Drug Development ISBN: 0471405205 ISBN-13(EAN): 9780471405207 Издательство: Wiley Рейтинг: Цена: 14839 р. Наличие на складе: Поставка под заказ.
Описание: Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: -Proteomics -Glycoprotein Mapping -Natural Products Dereplication -Lead Identification Screening -Open-Access LC/MS -In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Описание: Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.
Описание: This is Volume 2: Drug Disvery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
Описание: Describes the tools available for performing various assay techniques. This book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system and troubleshooting tools. It describes biochemical assay classes and non-class specific assay development for cell-based assays.
Описание: Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance Imaging (MRI) is one of the principal imaging modalities because it allows information to be gathered non-invasively. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.
Описание: The Process of New Drug Discovery and Development, Second Edition presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new edition reports on the scientific advances in new drug discovery and development for areas such as combinatorial chemistry, screening technologies, metabonomics, and preclinical testing. It also greatly expands its focus on the business aspects of bringing drugs to market and offers coverage of essential topics for companies involved in drug development, such as the financial aspects of establishing a start-up pharmaceutical enterprise, the regulatory process, risk assessment, liability and litigation, and patent law.
Описание: Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. This book offers a tool box for those who have a general interest in biomarker research.
Автор: Lednicer Название: New Drug Discovery and Development ISBN: 0470007508 ISBN-13(EAN): 9780470007501 Издательство: Wiley Рейтинг: Цена: 12331 р. Наличие на складе: Поставка под заказ.
Описание: A case history approach to drug synthesis and discovery Discover the origins of some of today`s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval.
Описание: Discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. This book emphasises on industrial applications and provides an introduction to the biocatalysts, modern expression hosts, directed evolution, high throughput screening, and bioprocess engineering.
Описание: Many times druwork fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:*Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.*Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.
Автор: Rogge Mark C Название: Preclinical Drug Development ISBN: 157444882X ISBN-13(EAN): 9781574448825 Издательство: Informa Рейтинг: Цена: 13010 р. Наличие на складе: Нет в наличии.
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