Описание: Provides an overview of the biomedical and environmental aspects of toxicology. This book not only delivers a review of the essential components of toxicology, it also looks at the systemic responses of toxic substance available anywhere.
Автор: Murray, Lindsay Название: Toxicology Handbook ISBN: 0729542246 ISBN-13(EAN): 9780729542241 Издательство: Elsevier Science Рейтинг: Цена: 5890 р. 6544.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Takayuki Shibamoto Название: Introduction to Food Toxicology, ISBN: 0126400253 ISBN-13(EAN): 9780126400250 Издательство: Elsevier Science Рейтинг: Цена: 4203 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides the basic principles of food toxicology. This book features coverage of areas of concern to consumers, such as toxicological implications of food adulteration (as seen in ethylene glycol in wines or the Spanish olive oil disaster) or pesticide residues. It is intended for students in toxicology, environmental studies and dietetics.
Описание: This 3rd edition contains updated overview chapters on immunochemical and molecular techniques and features entirely new chapters covering immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology.
Автор: Timbrell John Название: Introduction To Toxicology Ed3 ISBN: 0415247632 ISBN-13(EAN): 9780415247634 Издательство: Informa Рейтинг: Цена: 5204 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This third edition of Introduction to Toxicology caters for this need in a clear and easy-to-read style, featuring up-to-the-minute information, relevant toxicological examples that reinforce principles, end-of-chapter essay questions, new and redrawn illustrations, glossary of terms, and extensively revised bibliography. The book describes the fundamental principles of absorption, distribution, metabolism and excretion, as well as the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.
Описание: Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
Описание: The management of the risks associated with chemicals is an international challenge: it gained a prominent place on Agenda 21 of the UN Conference on
Environment and Development (UNCED), held in Rio de Janeiro in 1992. Successful management must be based on the development and harmonization of risk assessment methods.
This book contains the basic background information on sources and emissions, distribution and fate processes, toxicology and ecotoxicology and estimation methodologies.
It puts basic principles and methodologies for hazard and risk assessment of chemicals in their legislative context. The book supports the Uniform System for the Evaluation of
Substances (USES), a computerised risk assessment system. The book contains essential information for students of the environmental sciences and for those professionally involved in
developing field of risk assessment and management of chemicals.
Описание: Introduction to Neurobehavioral Toxicology: Food and Environment examines the effects of chemicals on the central and peripheral nervous system and the subsequent changes in behavior, with a focus on the toxicity of food components and behavioral effects of environmental toxicants. Topics addressed include acute and chronic effects, reversible and irreversible consequences, functional disorders of the nervous system, neurobehavioral dysfunctions, and the underlying neurobiological mechanisms. It also presents the neurobehavioral effects of natural food components, food contaminants, and food additives and assesses neurotoxic hazards of food-related chemicals, natural food factors, and neurotoxic food contaminants and additives.
Автор: Takayuki Shibamoto Название: Introduction to Food Toxicology, ISBN: 0123742862 ISBN-13(EAN): 9780123742865 Издательство: Elsevier Science Рейтинг: Цена: 7008 р. Наличие на складе: Нет в наличии.
Описание: The rapidly expanding field of food safety includes many new developments in the understanding of the entire range of toxic compounds found in foods -- whether naturally occurring or having been introduced by industry or food processing methods. This 2e of Introduction to Food Toxicology explores these developments while continuing to provide a core understanding of the basic principles of food toxicology.
Описание: This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.
Автор: Burczynski, Michael E. Название: Introduction to toxicogenomics ISBN: 0849313341 ISBN-13(EAN): 9780849313349 Издательство: Informa Рейтинг: Цена: 13114 р. Наличие на складе: Нет в наличии.
Описание: Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this emerging subdiscipline. The book introduces the overall concept underlying microarray/oligonucleotide array-based genomic analysis and how it fits into the field of biomedical research. These discussions provide an overview of the actual mechanics of the analyses themselves and offer insights on handling and quality control. An important feature is the book's focus on the basics of data analysis and clustering methods, such as genetic algorithms, used for analyzing large-scale datasets derived from gene chip expression data.
Описание: This text examines in vitro cytotoxicology, which offers new methodologies to toxicity testing. This discipline of modern toxicology is gaining increasing
acceptance as a viable alternative to traditional testing methods. The text discusses the application of in vitro cytotoxicology to toxicity testing and human risk assessment, and analyzes
the advantages and limitations of the tests performed under scientific and regulatory conditions.
The book also reviews the optimum utilization of certain tests for specific
groups of chemicals relevant to validation programmes currently in progress. The text summarizes in vitro toxicity testing and other cell culture methods; presents prevailing mechanisms
of in vitro cytotoxicology and cellular toxicity; and examines testing strategies, the role of validation, and the advantages and limitations of extrapolating data from in vitro testing to
human cytotoxicology potential.
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