Описание: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Автор: Matsumoto Rae R., Bowen Wayne D., Su Tsung-Ping Название: Sigma Receptors / Chemistry, Cell Biology and Clinical Implications ISBN: 0387365125 ISBN-13(EAN): 9780387365121 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. This information is put in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point from which future studies and research directions can easily be developed. Major advances in our understanding of sigma receptors have been made during the past few years. This book will facilitate exciting new research that could lead to significant advances in the treatment of neurologic, psychiatric, cardiovascular, immunologic, and gastrointestinal disorders through a better understanding of sigma receptors.
Автор: Stanford Название: Receptors ISBN: 0199638829 ISBN-13(EAN): 9780199638826 Издательство: Oxford Academ Рейтинг: Цена: 13464.00 р. Наличие на складе: Поставка под заказ.
Описание: A comprehesive review of methods that can be used for studying cellular receptors, examining how each technique can be used on different receptor types. It offers comprehensive coverage of a wide range of techniques, exploring up-to-date developments rather than established methods.
Автор: Kim A. Neve (Ed.) Название: The Dopamine Receptors ISBN: 1603273328 ISBN-13(EAN): 9781603273329 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This revised book serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. There are new chapters on dopamine receptor-interacting proteins and on dopamine receptor oligomerization.
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