Автор: Hedderwick, Mairi Название: Katie morag delivers the mail ISBN: 1849410917 ISBN-13(EAN): 9781849410915 Издательство: Random House - Penguin Рейтинг: Цена: 1187.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Welcome to the Island of Struay, home of one of the best-loved characters in children`s books and as seen on TV - Katie Morag McColl!When the village mail gets muddled, it`s up to Katie Morag to sort things out - with a little help from Grannie Island and her tractor. . .
Автор: Li, Xiao C Zhuo, Jia L Название: Renin-angiotensin system and the kidney ISBN: 1615046747 ISBN-13(EAN): 9781615046744 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 4712.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.
Автор: Mai Jia Название: Decoded ISBN: 0374135800 ISBN-13(EAN): 9780374135805 Издательство: Holtzbrink(MPS)/MPS Цена: 2391.00 р. Наличие на складе: Нет в наличии.
Автор: Mai, Joseph Название: Jean-pierre and luc dardenne ISBN: 0252077113 ISBN-13(EAN): 9780252077111 Издательство: Wiley EDC Рейтинг: Цена: 2915.00 р. Наличие на складе: Поставка под заказ.
Описание:
For well over a decade, Jean-Pierre and Luc Dardenne have produced highly original and ethically charged films that immerse their audiences in an intense and embodied viewing experience. Their work has consistently attracted international recognition, including the rare feat of two Palmes d'Or at Cannes.
In this first book-length study of the Belgian brothers, Joseph Mai delivers sophisticated close analyses of their directorial style and explores the many philosophical issues dealt with in their films (especially the ethics of Emmanuel Levinas). Mai discusses the Dardennes' varied and searching career from its inception in the late 1970s, starting with the working-class political consciousness and lost utopias of their documentary period; passing through their transition toward fictional narrative, experimental techniques, and familial themes; and finishing with a series of in-depth and philosophically informed interpretations of the brothers' more recent work. In such highly influential films such as La promesse, Rosetta, The Son, and The Child, the brothers have recast filmmaking through what Mai calls a "sensuous realism"--realism capable of touching the audience with the most compelling problems and moral dilemmas of contemporary society. This volume also features an interview in which the Dardennes discuss their approach to film production and the direction of actors.
Автор: Cousins Lucy Название: Maisy`s First Colors: A Maisy Concept Book ISBN: 0763668044 ISBN-13(EAN): 9780763668044 Издательство: Random House (USA) Цена: 735.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: What a concept! Bright colors and bouncy, rhyming text in a Maisy board book make early learning friendly and fun.
Charleys picked bananas, a big yellow bunch! Green pears for Cyril,munch, munch, munch! Maisy and her friends all have their favorite foods, from Tallulahs oranges to Eddies blue lollipop to Maisys juicy red apples. When they all join together for a picnic, they make a tasty rainbow yum!
Автор: Jiang, Jia Название: Rejection Proof ISBN: 1847941451 ISBN-13(EAN): 9781847941459 Издательство: Random House - Penguin Рейтинг: Цена: 1451.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Rejection? It`s nothing to be afraid of... Maybe you avoid situations where you might be rejected. In this book, the author shares what he learned in his 100 Days of Rejection, explaining how to turn a `no` into a `yes`.
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