The Role of regulators in Capital Markets of Pakistan, Abdul Basit Nagda
Название: Tumor Angiogenesis Regulators ISBN: 1466580976 ISBN-13(EAN): 9781466580978 Издательство: Taylor&Francis Рейтинг: Цена: 23375 р. Наличие на складе: Невозможна поставка.
Описание: The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and other metabolic disorders can influence the development and growth of cancer. It is of significant interest not only to oncologists but also to a wide range of medical practitioners and researchers.
Автор: Prosser, Tony Название: Law and the Regulators ISBN: 0198763913 ISBN-13(EAN): 9780198763918 Издательство: Oxford Academ Цена: 7532 р. Наличие на складе: Поставка под заказ.
Описание: An account of the legal and practical decision-making by the regulators of privatized utilities and of other areas of enterprise in the UK, including independent broadcasting and civil aviation. Prosser also assesses the implications of increasing competition and of social goals, such as the provision of public service to all.
Описание: The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton,
Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as
molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guan
ne nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex
array of downstream effectors.
Since the last "Methods in Enzymology" volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new
directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model
cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.
This
volume includes a database for Ras family proteins and their effectors and regulators. It is complimentary to volume 406 that provides coverage of the Rho family. It includes over 150
international contributors.
Автор: Barth James R., Caprio Gerard Jr., Levine Ross Название: Guardians of Finance: Making Regulators Work for Us ISBN: 0262017393 ISBN-13(EAN): 9780262017398 Издательство: MIT Press Рейтинг: Цена: 2304 р. Наличие на складе: Поставка под заказ.
Описание:
The recent financial crisis was an accident, a "perfect storm"fueled by an unforeseeable confluence of events that unfortunately combined to bringdown the global financial systems. And policy makers? They did everything theycould, given their limited authority. It was all a terrible, unavoidable accident.Or at least this is the story told and retold by a chorus of luminaries thatincludes Timothy Geithner, Henry Paulson, Robert Rubin, Ben Bernanke, and AlanGreenspan.
In " Guardians of Finance," economists James Barth, Gerard Caprio, and Ross Levine argue that the financialmeltdown of 2007 to 2009 was no accident; it was negligent homicide. They show thatsenior regulatory officials around the world knew or should have known that theirpolicies were destabilizing the global financial system, had years to process theevidence that risks were rising, had the authority to change their policies--and yetchose not to act until the crisis had fully emerged.
The currentsystem, the authors write, is simply not designed to make policy choices on behalfof the public. It is virtually impossible for the public and its elected officialsto obtain informed and impartial assessment of financial regulation and to holdregulators accountable. Barth, Caprio, and Levine propose a reform to counter thissystemic failure: the establishment of a "Sentinel" to provide aninformed, expert, and independent assessment of financial regulation. Its sole powerwould be to demand information and to evaluate it from the perspective of thepublic--rather than that of the financial industry, the regulators, orpoliticians.
Описание: The subject of this volume is a comprehensive examination of the biochemistry and biology of all classes of known PAS proteins, with the intention that readers will find insight into their own work and ideas from study of the multitude of PAS protein functions. PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.
Описание: Covers topics such as the structure and identification of functional domains of G proteins, and activation of G proteins by receptors or other regulators. This text takes an approach to studying common experimental questions at various different levels related to G proteins.
Автор: Nathan P. Colowick Название: Cellular Regulators, Part B: Calcium & Lipids,141 ISBN: 0121820416 ISBN-13(EAN): 9780121820411 Издательство: Elsevier Science Рейтинг: Цена: 6347 р. Наличие на складе: Поставка под заказ.
Автор: David Siderovski Название: Regulators of G Protein Signalling, Part B,390 ISBN: 012182795X ISBN-13(EAN): 9780121827953 Издательство: Elsevier Science Рейтинг: Цена: 19635 р. Наличие на складе: Поставка под заказ.
Описание: Provides the treatment of Regulators of G Protein Signalling, Part B. This volume also covers the RSG protein superfamily including RZ, R4, R7, R12, RhoGEF, and GRK, as well as other heterotrimeric G-protein signaling regulators.
Автор: Slobodan Vukicevic; Kuber Sampath Название: Bone Morphogenetic Proteins: Systems Biology Regulators ISBN: 3319475053 ISBN-13(EAN): 9783319475059 Издательство: Springer Рейтинг: Цена: 20789 р. Наличие на складе: Поставка под заказ.
Автор: Chen Название: Novel Apoptotic Regulators in Carcinogenesis ISBN: 9400749163 ISBN-13(EAN): 9789400749160 Издательство: Springer Рейтинг: Цена: 24140 р. Наличие на складе: Поставка под заказ.
Описание: Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.
Автор: Shleifer Andrei Название: Failure of Judges and the Rise of Regulators ISBN: 0262529521 ISBN-13(EAN): 9780262529525 Издательство: MIT Press Рейтинг: Цена: 3287 р. Наличие на складе: Поставка под заказ.
Описание:
A noted economist argues that the ubiquity of regulation can be explained by its greater efficiency when compared to litigation.
Government regulation is ubiquitous today in rich and middle-income countries--present in areas that range from workplace conditions to food processing to school curricula--although standard economic theories predict that it should be rather uncommon. In this book, Andrei Shleifer argues that the ubiquity of regulation can be explained not so much by the failure of markets as by the failure of courts to solve contract and tort disputes cheaply, predictably, and impartially. When courts are expensive, unpredictable, and biased, the public will seek alternatives to dispute resolution. The form this alternative has taken throughout the world is regulation.
The Failure of Judges and the Rise of Regulators gathers Shleifer's influential writings on regulation and adds to them a substantial introductory essay in which Shleifer critiques the standard theories of economic regulation and proposes "the Enforcement Theory of Regulation," which sees regulation as the more efficient strategy for social control of business. Subsequent chapters present the theoretical and empirical case against the efficiency of courts, make the historical and theoretical case for the comparative efficiency of regulation, and offer two empirical studies suggesting circumstances in which regulation might emerge as an efficient solution to social problems. Shleifer does not offer an unconditional endorsement of regulation and its expansion but rather argues that it is better than its alternatives, particularly litigation.
Contributors Nicola Gennaioli, Anthony Niblett, Richard A. Posner, Simeon Djankov, Rafael La Porta, Florencio Lopez-de-Silanes, Edward L. Glaeser, Simon Johnson, Casey B. Mulligan
Автор: David Siderovski Название: Regulators of G Protein Signalling, Part A,389 ISBN: 0121827941 ISBN-13(EAN): 9780121827946 Издательство: Elsevier Science Рейтинг: Цена: 19635 р. Наличие на складе: Поставка под заказ.
Описание: Presents a treatment of G-Protein Signaling, Part A, and covers general methods of analysis of RGS protein analysis, including expression and post-translational modification, assays of GAP activity and allosteric control, electrophysiological methods and RGS-insensitive Ga subunits, and mouse models of RGS protein action.
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