Описание: Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.
Автор: K. Wirtz Название: Membrane Receptors, Dynamics, and Energetics ISBN: 1468453378 ISBN-13(EAN): 9781468453379 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A NATO Advanced Study Institute on "Membrane Receptors, Dynamics and Energetics" was held in order to consider recent developments in membrane receptor research. Presentations and discussions focussed on signal transduction mechanisms (e.g. 2 G-proteins, transducin, Ca ]) and on the structure and func- tion of some selected receptors (i.e. low density lipoprotein receptor, acetylcholine receptor, growth factor receptors, toxin receptors). These topics were put in the larger con- text of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth discussions of energy transduc- tion and transport mechanisms. Specialized membrane systems were discussed including chloroplasts and chromaffin granules. Functional relationships with specific lipids (e.g. phospho- inositides, lipid A) were major topics of discussion. This book presents the content of the major lectures and a selection of most relevant posters presented during the course of the Institute. This book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics of re- ceptor, membrane and bioenergetics research that were at the center of interest during our stay on the Island of Spetsai from August 17 to 30, 1986.
Автор: Cheryl S. Watson Название: The Identities of Membrane Steroid Receptors ISBN: 146135028X ISBN-13(EAN): 9781461350286 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New experimental tools have been brought to bear on the topic of receptors for steroids which mediate non-genomic actions, and thus investigative activity and focus regarding this type of steroid receptor has recently increased significantly.
Автор: J. Marshall Clark; Fumio Matsumura Название: Membrane Receptors and Enzymes as Targets of Insecticidal Action ISBN: 1468451154 ISBN-13(EAN): 9781468451153 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The volume which resulted from this symposium, -Membranes Receptors and Enzymes as Targets of Insecticidal Action-, details a number of bio- chemical modes of action of insecticides on the insect nervous system.
Автор: Ralph Bradshaw Название: Surface Membrane Receptors ISBN: 1468427741 ISBN-13(EAN): 9781468427745 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The NATO Advanced Study Institute entitled "Surface Membrane Receptors: Interface Between Cells and Environment" was held in Bellagio, Italy September 13-21, 1975.
Автор: A.E. Evangelopoulos; J.P. Changeux; L. Packer; T.G Название: Receptors, Membrane Transport and Signal Transduction ISBN: 3642742025 ISBN-13(EAN): 9783642742026 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on Receptors, Membrane Transport and Signal Transduction held on the Island of Spetsai, Greece, August 16-27, 1988
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